蘇怡璇 Yi-Hsien Su, PhD

• 美國加州大學聖地牙哥分校 斯克里普斯海洋研究所 海洋生物學 博士 2005

• 國立清華大學 生命科學系 生物醫學科學組 碩士 1997

• 國立臺灣大學 動物學系 學士 1995

• 中央研究院 細胞與個體生物研究所 研究員 2022 - 迄今

• 台灣發育生物學會 理事 2023 - 迄今

• 科技部傑出研究獎 2020

• 中央研究院年輕學者研究著作獎 2014

• 科技部吳大猷先生紀念獎 2014

• 全球青年學會(GYA)會員 2010

(標記*為通訊作者) 

1. Fan, T.P., Lee, J.R., Lin, C.Y., Chen, Y.C., Cutting, A.E., Cameron, R.A., Yu, J.K., Su, Y.H.* (2024) Deep homology of a brachyury regulatory syntax and origin of the notochord, bioRxiv 2024.12.12.628285, under review. 

2. Pérez-Posada, A.*, Lin, C.Y., Fan, T.P., Lin, C.Y., Chen, Y.C., Gómez-Skarmeta, J.L., Yu, J.K., Su, Y.H.*, Tena, J.J.* (2024) Hemichordate cis-regulatory genomics and the gene expression dynamics of deuterostomes, Nature Ecology & Evolution, 8, 2213-2227. 

3. Lin, C.Y., Marlétaz, F., Pérez-Posada, A., Martínez García, P.M., Schloissnig, S., Peluso, P., Conception, G.T., Bump, P., Chen, Y..C., Chou, C., Lin, C.Y., Fan, T.P, Tsai, C.T., Gómez Skarmeta, J.L., Tena, J.J., Lowe, C.J., Rank, D.R., Rokhsar, D.S.*, Yu, J.K.*, Su, Y.H.* (2024) Chromosome-level genome assemblies of two hemichordates provide new insights into deuterostome origin and chromosome evolution, PLOS Biology, 22(6): e3002661. 

4. Chou, C., Lin, C.Y., Lin, C.Y., Wang, A., Fan, T.P., Wang, K.T., Yu, J.K., Su, Y.H.* (2024) Tracing the evolutionary origin of chordate somites in the hemichordate Ptychodera flava, Integrative & Comparative Biology, icae020. 

5. Martin, E.C., Le Targa, L., Tsakou-Ngouafo, L., Fan, T.P., Lin, C.Y., Xiao, J., Huang, Z., Yuan, S., Xu, A., Su, Y.H., Petrescu, A-J.*, Pontarotti, P.*, Schatz, D.G.* (2023) Insights into RAG evolution from the identification of “missing link” family A RAGL transposons, Molecular Biology and Evolution, 40(11):msad232. 

6. Zhang, P., Zhu, Y., Guo, Q., Li, J., Zhan, X., Yu, H., Xie, N., Tan, H., Lundholm, N., Garcia-Cuetos, L., Martin, M.D., Subirats, M.A., Su, Y.H., Ruiz-Trillo, I., Martindale, M.Q., Yu, J.K., Gilbert, M.T.P., Zhang, G.*, Li, Q.* (2023) On the origins and evolution of RNA editing in metazoans, Cell Reports, 42(2):112112. 

7. Chang, W.L. and Su, Y.H.* (2022) Zygotic hypoxia-inducible factor alpha regulates spicule elongation in the sea urchin embryo, Developmental Biology, 484, 63-74. 

8. Gil-Gálvez, A., Jiménez-Gancedo, S., Pérez-Posada, A., Franke, M., Acemel, R.D., Lin, C.Y., Chou, C., Su, Y.H., Yu, J.K., Bertrand, S., Schubert, M., Escrivá, H., Tena, J.J.*, Gómez-Skarmeta, J.L. (2022) Gain of gene regulatory network interconnectivity at the origin of vertebrates. Proceedings of the National Academy of Sciences of the United States of America, 119(11): e2114802119. 

9. Su, Y.H.* (2022) Dorsal-ventral axis formation in sea urchin embryos, Current Topics in Developmental Biology issue “Gene Regulatory Mechanisms in Development and Evolution: Insights from Echinoderms”, 146, 183-210 (invited book chapter). 

10. Lin, C.Y., Yu, J.K.*, and Su, Y.H.* (2021) Evidence for BMP-mediated specification of primordial germ cells in the indirect-developing hemichordate, Evolution & Development, 23, 28-45. 

11. Lin, C.Y., Lu, M.Y.J., Yue, J.X., Li, K.L., Le Petillon, Y., Yong, L.W., Chen, Y.H., Tsai, F.Y., Lyu, Y.F., Chen, C.Y., Hwang, S.P.L., Su, Y.H.*, and Yu, J.K.* (2020) Molecular asymmetry in the cephalochordate embryo revealed by single-blastomere transcriptome profiling, PLOS Genetics, 16(12): e1009294. 

12. Su, Y.H.* and Ota, K.G. (2020) Editorial: EvoDevo research in Asia, Evolution & Development, 22, 407-408. 

13. Yu, J.K.* and Su, Y.H. (2020) The evolution of the neural border and peripheral nervous system-Insights from invertebrate deuterostome animals (invited book chapter). Chapter 3 of Evolving Neural Crest Cells, edited by Brain Frank Eames, Danial Meulemans Medeiros, and Igor Adameyko, CRC Press. 

14. Wang, Y.T., Tseng, T.L., Kuo, Y.C., Yu, J.K., Su, Y.H., Poss, K.D., and Chen, C.H.* (2019) Genetic reprogramming of positional memory in a regenerating appendage. Current Biology, 29, 4193-4207. 

15. Coffman J.A.* and Su, Y.H.* (2019) Redox regulation of development and regeneration. Current Opinion in Genetics & Development: Developmental mechanisms, patterning and evolution, 57, 9-15 (invited review). 

16. Su, Y.H.*, Chen, Y.C., Ting, H.C., Fan, T.P., Lin, C.Y., Wang, K.T., and Yu, J.K.* (2019) BMP controls dorsoventral and neural patterning in indirect-developing hemichordates providing insights into a possible origin of chordates. Proceedings of the National Academy of Sciences of the United States of America, 116, 12925-12932. 

17. Lin, C.Y., Oulhen, N., Wessel, G., and Su, Y.H.* (2019) CRISPR/Cas9-mediated genome editing in sea urchins. Methods in Cell Biology, 151, 305-321 (Book Chapter). 

18. Campanale, J.P.*, Hamdoun, A.*, Wessel, G.M., Su, Y.H., and Oulhen, N. (2019) Methods to label, isolate, and image sea urchin small micromeres, the primordial germ cells (PGCs). Methods in Cell Biology, 150, 269-292 (Book Chapter).

19. Fan, T.P., Ting, H.C., Yu, J.K., and Su, Y.H.* (2018) Reiterative use of FGF signaling in mesoderm development during embryogenesis and metamorphosis in the hemichordate Ptychodera flava. BMC Evolutionary Biology, 18, 120. 

20. Luttrell, S.M., Su, Y.H., and Swalla, B.J.* (2018) Getting a head with Ptychodera flava larval regeneration. Biological Bulletin, 234, 152-164. 

21. Hu, M., Tseng, Y.C., Su, Y.H., Lein, E., Lee, H.G., Lee, J.R., Dupont, S., and Stumpp, M.* (2017) Variability in larval gut pH regulation defines sensitivity to ocean acidification in six species of the Ambulacraria superphylum. Proceedings of the Royal Society B-Biological Sciences, 284, 20171066. 

22. Chang, W.L.#, Chang, Y.C.#, Lin, K.T., Li, H.R., Pai, C.Y., Chen, J.H., and Su, Y.H.* (2017) Asymmetric distribution of hypoxia-inducible factor α regulates dorsoventral axis in the early sea urchin embryo. Development, 144, 2940-2950 (#contributed equally; cover and feature article). 

23. Su, Y.H.* and Yu, J.K.* (2017) EvoDevo: Changes in developmental controls underlying the evolution of animal body plans. Developmental Biology, 427, 177-178 (Editorial for the special issue). 

24. Cui, M. #, Lin, C.Y. #, and Su, Y.H.* (2017) Recent advances in functional perturbation and genome editing techniques in studying sea urchin development. Briefings in Functional Genomics, 16, 309-318 (invited review; #contributed equally). 

25. Chang, Y.C., Pai, C.Y., Chen, Y.C., Ting, H.C., Martinez, P., Telford, M.J., Yu, J.K., and Su, Y.H.* (2016) Regulatory circuit rewiring and functional divergence of the duplicate admp genes in dorsoventral axial patterning. Developmental Biology, 410, 108-118. 

26. Lin, C.Y. and Su, Y.H.* (2016) Genome editing in sea urchin embryos by using a CRISPR/Cas9 system. Developmental Biology, 409, 420-428. 

27. Lin, C.Y., Tung, C.H., Yu, J.K.*, and Su, Y.H.* (2016) Reproductive periodicity, spawning induction, and larval metamorphosis of the hemichordate acorn worm Ptychodera flava. J Exp Zool B, 326, 47-60. 

28. Simakov, O.*, Kawashima, T., Marlétaz, F., Jenkins, J., Koyanagi, R., Mitros, T., Hisata, K., Bredeson, J., Shoguchi, E., Gyoja, F., Yue, J.X., Chen Y.C., Freeman, R.M. Jr, Sasaki, A., Hikosaka-Katayama, T., Sato, A., Fujie, M., Baughman, K.W., Levine, J., Gonzalez, P., Cameron, C., Fritzenwanker, J.H., Pani, A.M., Goto, H., Kanda, M., Arakaki, N., Yamasaki, S., Qu, J., Cree, A., Ding, Y., Dinh, H.H., Dugan, S., Holder, M., Jhangiani, S.N., Kovar, C.L., Lee, S.L., Lewis, L.R., Morton, D., Nazareth, L.V., Okwuonu, G., Santibanez, J., Chen, R., Richards, S., Muzny, D.M., Gillis, A., Peshkin, L., Wu, M., Humphreys, T., Su, Y.H., Putnam, N., Schmutz, J., Fujiyama, A., Yu, J.K., Tagawa, K., Worley, K.C., Kirschner, M.W., Lowe, C.J., Satoh, N.*, Rokhsar, D.S.*, and Gerhart, J.* (2015) Hemichordate genomes and deuterostome origins. Nature, 527, 459-465. 

29. Andrikou, C., Pai, C.Y., Su, Y.H.*, and Arnone, M.I.* (2015) Logics and properties of a genetic regulatory program that drives embryonic muscle development in an echinoderm. eLife, 4:e07343. 

30. Fan, T.P. and Su, Y.H.* (2015) FGF signaling repertoire of the indirect developing hemichordate Ptychodera flava. Marine Genomics, 24, 167-175. 

31. Stumpp, M., Hu, M.Y, Tseng, Y.C., Guh, Y.J., Chen Y.C., Yu, J.K., Su, Y.H., and Hwang, P.P.* (2015) Evolution of extreme stomach pH in bilateria inferred from gastric alkalization mechanisms in basal deuterostomes. Scientific Reports, 5:10421. 

32. Satoh, N.*, Tagawa, K., Lowe, C., Yu, J.K., Kawashima, T., Takahashi, H., Ogasawara, M., Kirschner, M., Hisata, K., Su, Y.H., and Gerhart, J. (2014) On a possible evolutionary link of the stomochord of hemichordates to pharyngeal organs of chordates. genesis, 52, 925-934. 

33. Chen, S.H., Li, K.L., Lu, I.H., Wang, Y.B., Tung, C.H., Ting, H.C., Lin, C.Y., Lin, C.Y.*, Su, Y.H.*, and Yu, J.K.* (2014) Sequencing and analysis of the transcriptome of the acorn worm Ptychodera flava, an indirect developing hemichordate. Marine Genomics, 15, 35-43. 

34. Su Y.H.* (2014) Telling left from right: Left-right asymmetric controls in sea urchins. genesis, 52, 269-278 (invited review). 

35. Tung C.H. #, Cheng Y.R. #, Lin C.Y., Ho J.S., Yu J.K.*, and Su Y.H.* (2014) A new copepod with transformed body plan and unique phylogenetic position parasitic in the acorn worm Ptychodera flava. Biological Bulletin, 226, 69-80 (#contributed equally). 

36. Ikuta T.#, Chen Y.C.#, Annunziata R., Ting H.C., Tung C.H., Koyanagi R., Tagawa K., Humphreys T., Fujiyama A., Saiga H., Satoh N., Yu J.K., Arnone M.I., and Su Y.H.* (2013) Identification of an intact ParaHox cluster with temporal colinearity but residual spatial colinearity in the hemichordate Ptychodera flava. BMC Evolutionary Biology, 13, 129 (#contributed equally). 

37. Peterson K.J.*, Su Y.H., Arnone M.I., Swalla B.J., and King, B. (2013) microRNAs support the monophyly of enteropneust hemichordates. J Experimental Zoology B, 320, 368-374. 

38. Ben-Tabou de-Leon S.*, Su Y.H.*, Lin, K.T., Li, E., and Davidson, E.H.* (2013) Gene regulatory control in the sea urchin aboral ectoderm: Spatial initiation, signaling inputs, and cell fate lockdown. Developmental Biology, 374, 245-254. 

39. Luo Y.J. and Su Y.H.* (2012) Opposing Nodal and BMP signals regulate left-right asymmetry in the sea urchin larva. PLoS Biology, 10(10), e1001402. 

40. Wu H.R., Chen Y.T., Su Y.H., Luo Y.J., Holland L.Z., and Yu J.K.* (2011) Asymmetric localization of germline markers Vasa and Nanos during early development in the amphioxus Branchiostoma floridae. Developmental Biology, 353, 147-159. 

41. Chen J.H., Luo Y.J., and Su Y.H.* (2011) The dynamic gene expression patterns of transcription factors constituting the sea urchin aboral ectoderm gene regulatory network. Developmental Dynamics, 240, 410-421. 

42. Su Y.H.* (2009) Gene regulatory networks for ectoderm specification in sea urchin embryos. Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, 1789, 261-267 (invited review). 

43. Su Y.H., Li E., Geiss G.K., Longabaugh W.J., Kramer A., and Davidson E.H.* (2009) A perturbation model of the gene regulatory network for oral and aboral ectoderm specification in the sea urchin embryo. Developmental Biology, 329, 410-421. 

44. Nam J, Su Y.H., Lee P.Y., Robertson A.J., Coffman J.A., and Davidson E.H.* (2007) Cis-regulatory control of the nodal gene, initiator of the sea urchin oral ectoderm gene network. Developmental Biology, 306, 860-869. 

45. Churamani D, Boulware M.J., Geach T.J., Martin A.C., Moy G.W., Su Y.H., Vacquier V.D., Marchant J.S., Dale L, and Patel S.* (2007) Molecular characterization of a novel intracellular ADP-ribosyl cyclase. PLoS One, 2(8): e797. 

46. Roux, M.M., Townley, I.K., Raisch, M., Reade, A., Bradham, C., Humphreys, G., Gunaratne, H.J., Killian, C.E., Moy, G., Su, Y.H., Ettensohn, C.A., Wilt, F., Vacquier, V.D., Burke, R.D., Wessel, G., and Foltz, K.R.* (2006) A functional genomic and proteomic perspective of sea urchin calcium signaling and egg activation. Dev Biol., 300, 416-433. 

47. Sea Urchin Genome Sequencing Consortium* (2006) The genome of the sea urchin Strongylocentrotus purpuratus. Science, 314, 941-952. 

48. Su, Y.H. and Vacquier, V.D.* (2006) Cyclic GMP-specific phosphodiesterase-5 regulates motility of sea urchin spermatozoa. Mol. Biol. Cell, 17, 114-121. 

49. Su, Y.H.*, Chen, S.H, Zhou, H., and Vacquier, V.D. (2005) Tandem mass spectrometry identifies proteins phosphorylated by cyclic AMP-dependent protein kinase when sea urchin sperm undergo the acrosome reaction. Developmental Biology, 285, 116-125. 

50. Su, Y.H. and Vacquier, V.D.* (2002) A flagellar K+-dependent Na+/Ca2+ exchanger keeps Ca2+ low in sea urchin spermatozoa. Proc. Natl. Acad. Sci. USA, 99, 6743-6748. 

51. Jang, C.W., Chen C.H., Chen, C.C., Chen, Jy.J., Su, Y.H., and Chen, R.H.* (2002) TGF beta induces apoptosis through Smad-mediated expression of DAP-kinase. Nature Cell Biol., 4, 51-58. 

52. Tsai, Y.T.#, Su, Y.H.#, Fang, S.S., Huang, T.N., Qiu, Y., Jou, Y.S., Shih, H.M., Kung, H.J., and Chen, R.H.* (2000) Etk, a Btk family tyrosine kinase, mediates cellular transformation by linking Src to STAT3 activation. Mol. Cell Biol., 20, 2043-2054 (#contributed equally). 

53. Chen, R.H., Chang, M.C., Su, Y.H., Tsai, Y.T., and Kuo, M.L.* (1999) Interleukin-6 inhibits transforming growth factor-b-induced apoptosis through the phosphatidylinositol 3-kinase/Akt and signal transducers and activators of transcription 3 pathways. J. Biol. Chem., 274, 23013-23019. 

54. Hwang, S.P.L.*, Lin, Y.C., Su, Y.H., and Chen, C.P. (1999) Accelerated development of embryonic spicule and micromere-derived primary mesenchyme cell culture of the sea urchin Stomopneustes variolaris (Lamarck). Invertebr. Reprod. Dev., 35, 89-93. 

55. Chen, R.H.*, Su, Y.H., Chuang, R.L.C., and Chang, T.Y. (1998) Suppression of transforming growth factor-b-induced apoptosis through a phosphatidylinositol 3 kinase/Akt-dependent pathway. Oncogene, 17,1959-1968.