獲獎人簡介 ▞

林頌然 Sung-Jan Lin, MD, PhD

  • 特聘教授

  • 台灣生技醫藥發展基金會生物科技講座

  • 國立台灣大學醫學工程系/皮膚科/基因體與系統生物學學程/臨床醫學研究所特聘教授

  • 106台北市大安區芳蘭路49號 永齡生醫工程館625室

林頌然醫師現任台大醫學工程系教授以及台大發育生物學與再生醫學研究中心副主任。同時也擔任台大醫院皮膚科主治醫師。在林醫師的研究中，他將具有獨特結構和生長週期的微型器官-毛囊作為研究的材料，以了解毛囊如何與環境相互作用及如何對各種傷害做出反應，並從這些結果中了解組織再生的原理和機制。林醫師也對角膜組織再生有興趣，特別是角膜內皮細胞的部分。林醫師的實驗室結合生物學和組織工程學的技術，應用在提升組織再生的研究。他發表了超過120篇論文在研究相關的眾多期刊上，包含了Science, PNAS, Nature Communications, Biomaterials, Optics Letters…等國際期刊。也因此林醫師在研究的路上獲獎無數，並於2014年起擔任台灣生技醫藥發展基金會生物科技講座。

Education 學歷 ▞

國立台灣大學醫學系 學士(1991-1998)

國立台灣大學醫學工程 博士(2003-2006)

Current Position 現職 ▞

  • 特聘教授 國立台灣大學醫學工程系/皮膚科/基因體與系統生物學學程/臨床醫學研究所 2018/08~迄今

  • 合聘教授 國立清華大學 2019/08~迄今

  • 台灣生技醫藥發展基金會生物科技講座 2014/01 ~迄今

  • 副主任, 國立台大醫學院研發分處 2019/08 ~迄今

  • 副主任, 國立台大醫院醫研部 2019/08 ~迄今

  • 副主任, 國立台灣大學發育生物學與再生醫學研究中心 2016/08 ~迄今

  • 主治醫師, 國立台大醫院皮膚科2003/7 ~迄今

Honors 榮譽獎項 ▞

  • 優秀住院醫師, 國立台灣大學醫院 2002

  • 年輕學者研究著作獎, 中央研究院 2009

  • 吳大猷先生紀念獎, 科技部 2010

  • 優良教學獎, 國立台灣大學 2010

  • 基礎科學研究獎, 亞太理膚寶水基金會 2012

  • 青杏醫學獎, 財團法人青杏醫學文教基金會, 2012

  • 優良教學獎, 國立台灣大學 2013

  • 台灣生技醫藥發展基金會生物科技講座 2014 ~ 2024

  • 傑出研究獎, 科技部 2014

  • 傑出研究獎, 國立台灣大學醫院 2014

  • 李鎮源院長紀念醫學獎 2014

  • 徐有庠先生紀念基金會傑出教授獎 2017

  • 基礎科學研究獎, 亞太理膚寶水基金會 2018

Research Topics 研究領域 ▞

  1. 幹細胞與再生醫學

  2. 組織工程

  3. 毛囊生理

  4. 角膜內皮癒合機制

  5. 色素及黑色素細胞

  6. 生醫影像

Publications 學術論文發表 ▞

A. 期刊論文(擔任第一作者及通訊作者論文)

  1. Huang WY, Hong JB, Chang M, Wang SY, Lai SF, Chien HF*, Lin SJ*. Lower proximal cup and outer root sheath cells regenerate hair bulbs during anagen hair follicle repair after chemotherapeutic injury. Experimental Dermatology (in press)

  2. Shwartz Y#, Gonzalez-Celeiro M#, Chen CL#, Pasolli HA, Sheu SH, Fan SMY, Shamsi F, Assad S, Lin ETY, Zhang B, Tsai PC, He M, Tseng YH, Lin SJ*, Hsu YC*. Cell types promoting goosebumps form a niche to regulate hair follicle stem cells. Cell 182: 578-593, 2020. (# equal contribution) (Preview: Pascalau R, Kuruvilla R. A hairy end to a chilling event. Cell 182: 539-541, 2020)

  3. Wu YF, Ye RT, Pan MK, Lin SJ*, Tan HY*. A custom multiphoton microscopy platform for live imaging of mouse cornea and conjunctiva. Journal of Visualized Experiments 159, e60944, 2020.

  4. Chen CL, Huang WY, Wang EHC, Kang-Yu Tai KY, Lin SJ*. Functional complexity of hair follicle stem cell niche and therapeutic targeting of niche dysfunction for hair regeneration. Journal of Biomedical Science 27:43, 2020.

  5. Chang LY, Fan SMY, Liao YC, Wang WH, Chen YJ, Lin SJ*. Proteomic analysis reveals anti-fibrotic effects of blue light photobiomodulation on fibroblasts. Lasers in Surgery and Medicine 52:358-72, 2020.

  6. Wu YF, Wang CY, Yang TL, Tsao PN, Lin SJ*, Tan HY*. Intravital multiphoton microscopic imaging platform for ocular surface imaging. Experimental Eye Research 182:194-201, 2019.

  7. Huang WY, Lin ETY, Hsu YC, Lin SJ*. Anagen hair follicle repair: timely regenerative attempts from plastic extra-bulge epithelial cells. Experimental Dermatology 28:406-412, 2019.

  8. Fan SMY, Chang YT, Chen CL, Wang WH, Pan MK, Chen WP, Huang WY, Xu Z, Huang HE, Chen T, Plikus MV, Chen SK*, Lin SJ*. External light activates hair follicle stem cells through eyes via an ipRGC-SCN-sympathetic neural pathway. Proceedings of the National Academy of Sciences of USA 115:E6880-E6889, 2018.

  9. Fan SMY, Tsai CF, Yen CM, Lin MH, Wang WH, Chan CC, Chen CL, Phua KKL, Pan SH, Plikus MV, Yu SL, Chen YJ*, Lin SJ*. Inducing hair follicle neogenesis with secreted proteins enriched in embryonic skin. Biomaterials 167:121-131, 2018.

  10. Fan SMY, Chen PH, Tseng YT, Hong JB, Chen WH, Tsai TF, Lin SJ*. Preclinical evaluation of melanocyte transplantation by chitosan-based melanocyte spheroid patch to skin prepared by controlled sunburn blistering. Journal of Biomedical Materials Research Part B: Applied Biomaterials 106:2535-2543, 2018.

  11. Huang WY, Lai SF, Chiu HY, Chang M, Plikus MV, Chan CC, Chen YT, Tsao PN, Yang TL, Lee HS, Chi P, Lin SJ*. Mobilizing transit-amplifying cell-derived ectopic progenitors prevents hair loss from chemotherapy or radiation therapy. Cancer Research 77:6083-6096, 2017 (This paper was featured by New Scientist, BioWorld and ScienceTrends)

  12. Wang WH, Chien TH, Fan SMY, Huang WY, Lai SF, Wu JT, Lin SJ*. Activation of mTORC1 signaling is required for timely hair follicle regeneration from radiation injury. Radiation Research 188:681-689, 2017.

  13. Huang WY, Huang YC, Huang KS, Chan CC, Chiu HY, Tsai RY, Chan JY, Lin SJ*. Stress-induced premature senescence of dermal papilla cells compromises hair follicle epithelial-mesenchymal interaction. Journal of Dermatological Science 86:114-122, 2017.

  14. Chen KL, Chiu HY, Chan CC, Chan JY, Lin SJ*. Extensive cicatricial alopecia in a patient with long-term trichotillomania. Journal of Dermatology 43:226-8, 2016.

  15. Li YC, Lin MW, Yen MH, Fan SMY, Wu JT, Young TH, Cheng JY, Lin SJ*. Programmable laser-assisted surface microfabrication on a polyvinyl alcohol-coated glass chip with self-changing cell adhesivity for heterotypic cell patterning. ACS Applied Materials & Interfaces 7:22322-32, 2015.

  16. Chan CC, Fan MY, Wan WH, Lin SJ*. A two-stepped culture method for efficient production of trichogenic keratinocytes. Tissue Engineering Part C Methods 21:1070-9, 2015.

  17. Wu YF, Wang SH, Wu PS, Sabrina Fan MY, Chiu HY, Tsai TH, Lin SJ*. Enhancing hair follicle regeneration by nonablative fractional laser: assessment of irradiation parameters and tissue response. Lasers in Surgery and Medicine 47:331-41, 2015.

  18. Sheen YS, Fan SMY, Chan CC, Wu YF, Jee SH, Lin SJ*. Visible red light enhances physiological anagen entry in vivo and has direct and indirect stimulative effects in vitro. Lasers in Surgery and Medicine 47: 50-9, 2015.

  19. Lin IC, Chiu HY, Chan JY, Lin SJ*. Extensive scleredema with anhidrosis and recurrent heat stroke. Journal of American Academy of Dermatology.71:e99-e101, 2014.

  20. Chiu HY, Lin SJ*. Rendu-Osler-Weber syndrome. JAMA 312:714-2, 2014.

  21. Lin SJ, Foley J, Jiang TX, Yeh CY, Wu P, Foley A, Yen CM, Huang YC, Cheng HC, Chen CF, Reeder B, Jee SH, Widelitz RB, Chuong CM. Topology of feather melanocyte progenitor niche allows complex pigment patterns to emerge. Science 340:1442-5, 2013. (This article was highlighted by Kvajo M. A thing of beauty. Cell 154:700-701, 2013)

  22. Chiu HY, Lin SJ*. Postherpetic pseudohernia. JAMA 310:639-640, 2013.

  23. Huang YC, Chan CC, Lin WT, Chiu HY, Tsai RY, Tsai TH, Chan JY, Lin SJ*. Scalable production of controllable dermal papilla spheroids on PVA surfaces and the effects of spheroid size on hair follicle regeneration. Biomaterials 34:442-451, 2013.

  24. Lin SJ, Wideliz RB, Yue Z, Li A, Wu X, Jiang TX, Wu P, Chuong CM. Feather regeneration as a model for organogenesis. Development, Growth & Differentiation 55:139-48, 2013.

  25. Tsai TH#, Lin SJ#, Lee WR, Wang CC, Hsu CT, Chu T, Dong CY. Visualizing radiofrequency-induced skin interaction using multiphoton microscopy in vivo. Journal of Dermatological Science 65:95-101, 2012. (#equal contribution)

  26. Chan CC, Lin SJ*. Porphyria cutanea tarda. New England Journal of Medicine 365: 1128, 2011.

  27. Yen CM, Chan CC, Lin SJ*. High-throughput reconstitution of epithelial-mesenchymal interaction in folliculoid microtissues by biomaterial-facilitated self-assembly of dissociated heterotypic adult cells. Biomaterials 31:4341-4352, 2010.

  28. Chan CC, Lin SJ*. Serpentine supravenous hyperpigmentation. New England Journal of Medicine 363:e8, 2010.

  29. Wang CC, Li FC, Lin WC, Chen YF, Chen SJ, Lin SJ*, Dong CY. Early development of cutaneous cancer revealed by intravital nonlinear optical microscopy. Applied Physics Letters 97: 113702, 2010.

  30. Chiu HY, Lin SJ*. Fibrosing alopecia in a pattern distribution. Journal of the European Academy of Dermatology & Venereology 24:1113-4, 2010.

  31. Chiu HY, Lin SJ*. Female pattern hair loss in a patient with 17α-hydroxylase deficiency. Acta Dermato-Venereologica 90:329-30, 2010.

  32. Young TH, Tu HR, Chan CC, Huang YC, Yen MH, Cheng NC, Chiu HC, Lin SJ*. The enhancement of dermal papilla cell aggregation by extracellular matrix proteins through effects on cell-substratum adhesivity and cell motility. Biomaterials 30:5031-40, 2009.

  33. Chen WL, Chou CK, Lin MG, Chen YF, Jee SH, Tan HY, Tsai TH, Kim KH, Kim D, So PT, Lin SJ*, Dong CY. Single-wavelength reflected confocal and multiphoton microscopy for tissue imaging. Journal of Biomedical Optics 14:054026, 2009.

  34. Lin SJ, Tan HY, Kuo CJ, Wu RJ, Wang SH, Chen WL, Jee SH, Dong CY. Multiphoton autofluorescence spectral analysis for fungus imaging and identification. Applied Physics Letters 95:043703, 2009.

  35. Hovhannisyan VA, Su PJ, Lin SJ*, Dong CY. Quantifying thermodynamics of collagen thermal denaturation by second harmonic generation imaging. Applied Physics Letters 94:233902, 2009. (selected in Virtual Journals in Biological Physics Research)

  36. Su PJ, Chen WL, Hong JB, Li TH, Wu RJ, Chou CK, Chen SJ, Hu C, Lin SJ*, Dong CY. Discrimination of collagen in normal and pathological skin dermis through second-order susceptibility microscopy. Optics Express 17: 11161-11171, 2009.

  37. Tsai TH, Jee SH, Chan JY, Lee JN, Lee WR, Dong CY, Lin SJ*. Visualizing laser-skin interaction in vivo by multiphoton microscopy. Journal of Biomedical Optics 14: 024034, 2009.

  38. Tsai TH, Jee SH, Dong CY, Lin SJ*. Multiphoton microscopy in dermatological imaging. Journal of Dermatological Science 56:1-8, 2009.

  39. Young TH, Lee CY, Chiu HC, Hsu CJ, Lin SJ*. Self-assembly of dermal papilla cells into inductive spheroidal microtissues on poly (ethylene-co-vinyl alcohol) membranes for hair follicle regeneration. Biomaterials 29:3521-30, 2008.

  40. Lee JN, Jee SH, Lo W, Chan CC, Dong CY, Lin SJ*. The effect of depilatory agents as a penetration enhancer on human stratum corneum structures. Journal of Investigative Dermatology 128:2240-7, 2008. (Issue cover and highlighted in the editorials)

  41. Lin CY, Hovhannisyan V, Wu JT, Lin CW, Chen JH, Lin SJ*, Dong CY. Label-free imaging of Drosophila larva by multiphoton autofluorescence and second harmonic generation microscopy. Journal of Biomedical Optics 13:050502, 2008. (selected in Virtual Journals in Biological Physics Research)

  42. Hung JB, Lin SJ*. Frontal fibrosing alopecia in a premenopausal woman: a case report. Dermatologica Sinica 26:28-33, 2008.

  43. Chan CJ#, Lin SJ#, Hwang JJ, Sun CC, Jeng JS, Hwang BS, Chiu HC, Chen MF, Liau CS, Hsu HJ, Su TC. Xanthelasma is not associated with increased risk of carotid atherosclerosis in normolipidaemia. International Journal of Clinical Practice 62:221-7, 2008. (#equal contribution)

  44. Lin SJ, Lee JN, Lin CY, Chan CC, Lin MG, Wang CC, Tan HY, Tsai TH, Jee SH, Dong CY. Investigation of the mechanism of transdermal penetration enhancer: a comparison of multiphoton microscopy and electron microscopy. Proceedings of SPIE 6842, 684203, 2008.

  45. Tsai TH, Lee JN, Chan JY, Hsu JT, Tan HY, cong CY, Lee WR, Lin SJ*.Monitoring laser-tissue interaction by non-linear optics. Proceedings of SPIE 6842, 684202, 2008.

  46. Tan HY, Sun Y, Lo W, Teng SW , Wu RJ, Jee SH, Lin WC, Hsiao CH, Lin HC, Chen JF, Ma D, Huang S, Lin SJ*, Dong CY. Multiphoton fluorescence and second harmonic generation microscopy for imaging infectious keratitis. Journal of Biomedical Optics 12:024013, 2007. (selected in Virtual Journals in Biological Physics Research )

  47. Hong JB, Chiu HC, Chan JY, Chen RJ, Lin SJ*. A woman with iatrogenic androgenetic alopecia responding to finasteride. British Journal of Dermatology 156:754-5, 2007.

  48. Lin SJ*, Jee SH, Dong CY. Multiphoton microscopy: a new paradigm in dermatological imaging. European Journal of Dermatology 17:361-366, 2007.

  49. Lin MG, Chen WL, Lo W, Tan HY, Tsai TH, Jee SH, Lin SJ*, Dong CY. Three-dimensional skin imaging using the combination of reflected confocal and multiphoton microscopy. Proceedings of SPIE 6424: 64240E, 2007.

  50. Lin SJ, Hsu CJ, Wu RJ, Kuo CJ, Chen JS, Chan JY, Lin WC, Jee SH, Dong CY. Quantitative multiphoton imaging for guiding basal-cell carcinoma removal. Proceedings of SPIE 6424: 642404, 2007.

  51. Lin MG, Yang TL, Chiang CT, Kao HC, Lee JN, Lo W, Jee SH, Chen YF, Dong CY, Lin SJ*. Evaluation of dermal thermal damage by multiphoton autofluorescence and second harmonic generation (SHG) microscopy. Journal of Biomedical Optics 11:064006, 2006.

  52. Lin SJ, Jee SH, Kuo CJ, Wu RJ, Lin WC, Chen JS, Liao YH, Hsu CJ, Tsai TF, Chen YF, Dong CY. Discrimination of basal cell carcinoma from normal dermal stroma by quantitative multiphoton imaging. Optics Letters 31: 2756-2758, 2006. (selected in Virtual Journals in Biological Physics Research )

  53. Lin SJ, Lo W, Tan HY, Chan JY, Chen WL, Wang SH, Sun Y, Lin WC, Chen JS, Hsu CJ, Tjiu JW, Yu HS, Jee SH, Dong CY. Prediction of heat-induced collagen shrinkage by use of second harmonic generation microscopy. Journal of Biomedical Optics 11:034020, 2006.

  54. Lin SJ, Hsiao WC, Jee SH, Tsai TF, Yu HS, Lai JY, Young TH. Study on the effect of nylon-chitosan blended membranes on the spheroid forming activity of human melanocytes. Biomaterials 27:5079-88, 2006.

  55. Lin SJ, Jee SH, Hsiao WC, Yu HS, Tsai TF, Chen JS, Hsu CJ, Young TH. Enhanced cell survival of melanocyte spheroids in serum starvation condition. Biomaterials 27: 1462-1469, 2006.

  56. Lin SJ, Hsiao WC, Hsu CJ, Chen JS, Jee SH, Tsai TF, Yu HS, Young TH. The effect of serum concentration on the spheroid forming activity and cell growth of human melanocytes on chiotsan surface. Biomedical Engineering- Applications, Basis and Communications 18:42- 46, 2006.

  57. Lin SJ, Chen JS, Lo W, Sun Y, Chen WL, Chan JY, Tan HY, Lin WC, Hsu CJ, Young TH, Jee SH, Dong CY. Monitoring of collagen shrinkage by use of second harmonic generation microscopy. Proceedings of SPIE 6084: 196-205, 2006.

  58. Yang TL, Chiang CT, Kao HC, Lo W, Lin SJ*, Jee SH, Chen YF, Dong CY. Imaging of skin dermal thermal damage by multiphoton autofluorescence and second harmonic generation (SHG) microscopy. Proceedings of SPIE 6078:15-23, 2006.

  59. Lin SJ, Jee SH, Chan JY, Wu RJ, Lo W, Tan HY, Lin WC, Chen JS, Young, TH, Hsu CJ, Dong CY. Monitoring photoaging by use of multiphoton fluorescence and second harmonic generation microscopy. Proceedings of SPIE 6078: 8-14, 2006.

  60. Lin SJ, Wu RJ, Tan HY, Lo W, Lin WC, Young TH, Hsu CJ, Chen JS, Jee SH, Dong CY. Evaluating cutaneous photoaging by use of multiphoton fluorescence and second harmonic generation microscopy. Optics Letters 30: 2275-7, 2005. (selected in Virtual Journals in Biological Physics Research)

  61. Lin SJ, Jee SH, Hsiao WC, Lee SJ, Young TH. Formation of melanocyte spheroids on the chitosan-coated surface. Biomaterials 26:1413-1422, 2005.

  62. Lin SJ, Hsiao CY, Sun Y, Lo W, WC Lin, Jan GJ, Jee SH, Dong CY. Monitoring the thermally induced structural transitions of collagen using second harmonic generation microscopy. Optics Letters 30:622-4, 2005. selected in Virtual Journals in Biological Physics Research)

  63. Chan CC, Chen JS, Tsai TF, Lin SJ*. A cervical congenital asymptomatic atrophic band connected with a cephalad nipple-like projection: Rhabdomyomatous mesenchymal hamartoma in midline cervical cleft. Archives of Dermatology 141:1161-6, 2005.

  64. Lin SJ, Wu RJ, Lo W, Sun Y, Jee SH, Dong CY. Multiphoton fluorescence and second harmonic generation microscopy of different skin states. Proceedings of SPIE 5686, 67-72, 2005.

  65. Young CS, Chu CY, Lin SJ *. Vitiligo universalis associated with Evans syndrome and antiphospholipid syndrome —A case report and review of the literature. Dermatologica Sinica 22: 093-099, 2004.

  66. Lin SJ, Chiu HC. An asymptomatic preauricular subcutaneous nodule in a 65-year-old woman. Cutaneous angiomylipoma. Archives of Dermatology 139:381-6, 2003.

  67. Lin SJ, Chiu HC. Adult multiple xanthogranulomas with spontaneous resolution. Acta Dermato-Venereologica 83:157-8, 2003.

  68. Lin SJ, Hsu CJ, Chiu HC. Erythema ab igne caused by frequent hot bathig. Erythema ab igne caused by frequent hot bathing. Acta Dermato- Venereologica 82:478-9, 2002.

  69. Lin SJ, Tsai TF. A painless swelling on the anterior surface of the auricle in a 73-year-old man (Pseudocyst of the auricle). Dermatologica Sinica 20: 267-268, 2002.

  70. Lin SJ, Tsai TF, Hsiao CH. Sebaceous trichofollliculoma. Dermatologica Sinica 19:357-362, 2001.

  71. Lin SJ, Tsai TF, Hsiao CH. Hydroxyurea-induced symmetrical lower leg ulcers. Dermatologica Sinica 19:249-254, 2001.

B. 專書發表

  1. Lin SJ, Huang WY, Chen CC, Lei M, Hong JB. “Hair follicle stem cells and hair regeneration.” In: Tissue Engineering and Regeneration: Cell Engineering and Regeneration. (Redl H, Gimble J, Presen DM, Oreffo R, Wolbank S eds), Springer 2020.

  2. Wu YF, Tan HY, Lin SJ. “Long-term intravital imaging of cornea, skin and hair follicle by multiphoton microscope.” In: Imaging and Tracking Stem Cells: Methods ad Protocols (Methods in Molecular Biology, Springer Protocols), 2nd Edition, (Turksen K, ed.), Springer, 2019.

  3. Sun Y, Wen Lo, Su JW, Lin SJ, Jee SH, Dong CY. “Multiphoton polarization microscopy.” In: Handbook of Biomedical Nonlinear Optical Microscopy, (Masters B, So P eds.), Oxford University Press, 2008.

  4. Lin SJ, Chan CC, Hsu CJ. “Regenerative Medicine in Dermatology” In: Regenerative Medicine, (Liu HC, Chen CL eds), Ministry of Education, Taiwan, 2008.

  5. Chen HC，Lin SJ. “Arthropod induced dermatoses” In: Practical Dermatology，2nd Edition， National Taiwan University Hospital, Taipei, Taiwan, 2006.

C. 其他發表

1. 王維宏，范邁儀，林頌然。 毛囊幹細胞。科學月刊 2014年1月。