獲獎人簡介 ▞
蔡金吾 Jin-Wu Tsai, PhD
國立陽明交通大學腦科學研究所 專任教授
國立陽明交通大學研究發展處 研發長
台北市北投區 112 立農街二段 155 號(陽明校區)
蔡金吾老師現任國立陽明交通大學醫學院腦科學研究所教授,並兼任國立陽明交通大學研發長。蔡老師曾擔任Genentech Inc. 研究及發展部生醫影像組 科學經理 (Scientific Manager)(2010-2012)。2012返台加入國立陽明大學腦科學研究所 ,運用先進的跨領域技術(橫跨細胞分子、光學影像、程式設計、臨床與生物科技),目前主要研究中樞神經系統之發育、神經幹細胞複製與分化之動態過程。並延伸到大腦發育神經元突觸之相互連結,以及在神經退化、中風以及腦損傷過程中,腦部細胞之動態變化,期望以這樣的整合系統,發展出以神經再生為標的之幹細胞療法。
Education 學歷 ▞
國立台灣大學物理學及動物學 雙學士(1994-1998)
國立陽明大學微生物及免疫學碩士 碩士(1998-2000)
哥倫比亞大學細胞分子及生物物理學 博士(2002-2008)
Current Position 現職 ▞
國立陽明交通大學腦科學研究所 專任教授 2021~迄今
國立陽明交通大學研究發展處 研發長 2021~迄今
Honors 榮譽獎項 ▞
The Best Student Paper Award, International Society for Optical Engineering 2000
國立陽明大學「優秀碩士論文獎」2000
The Brunie Prize in Neural Stem Cell Research 2005
American Society for Cell Biology (ASCB) Predoctoral Student Travel Award 2005
AAAS/Science Program for Excellence in Science 2007
NIH National Graduate Student Research Festival Scholarship 2007
Taiwanese Bioscientist Association Student Travel Award 2007
The British Council Stem Cell Workshop Scholarship 2007
International Brain Research Organization Travel Grant for the World Congress of Neuroscience 2007
The Rover Award for Outstanding Achievement in Anatomy and Cell Biology 2008
Ph.D. degree with Distinction, Columbia University 2008
Spinal Cord Injury Research Program Postdoctoral Fellowship Award, Spinal Cord Injury Research Board, New York State Department of Health 2008
“Study Abroad” Postdoctoral Fellowship, National Science Council, Taiwan 2010
Recognition Award, Genentech Inc. 2011
Ruth L. Kirschstein National Research Service Awards for Individual Postdoctoral Fellows, National Institutes of Health, USA 2011
國科會「延攬特殊優秀人才」補助計畫 2012
第八屆「台法前鋒科學論壇」規劃委員,科技部 2014~2015
科技部「優秀年輕學者研究計畫」2017, 2014
榮總台聯大專題研究計畫成果壁報競賽第二名 2018
國立陽明大學「教學優良獎」 2018, 2015
第 15 屆「永信李天德青年醫藥科技獎」 2019
第 24 屆中央研究院「年輕學者研究著作獎」 2019
第 17 屆「有庠科技論文獎」,遠東徐有庠先生紀念基金會 國立陽明大學院級「教學傑出獎」 2019
台灣癲癇醫學會「癲癇研究論文獎」第一名 2019
科技部研究計畫複審委員 2018~2020
連續六年獲國立陽明大學醫學院「醫學系學生網路教學評估優良教師」2015~2020
科技部 108 年度「傑出研究獎」 2020
台灣癲癇醫學會「癲癇傑出研究獎」 2020
獲選國立陽明大學 45 週年校慶「飛耀陽明 5 大創新」2020
Research Topics 研究領域 ▞
運用先進的跨領域技術(橫跨細胞分子、光學影像、程式設計、臨床與生物科技)研究中樞神經系統之發育、神經幹細胞複製與分化之動態過程。並延伸到大腦發育神經元突觸之相互連結,以及在神經退化、中風以及腦損傷過程中,腦部細胞之動態變化,期望以這樣的整合系統,發展出以神經再生為標的之幹細胞療法。
Publications 學術論文發表 ▞
A. 期刊論文
Tsai MH, Muir AM, Wang WJ, Kang YN, Yang KC, Chao NH, Wu MF, Chang YC, Porter BE, Jansen LA, Sebire G, Deconinck N, Fan WL, Su SC, Chung WH, Almanza Fuerte EP, Mehaffey MG, University of Washington Center for Mendelian Genomics, Ng CC, Chan CK, Lim KS, Leventer RJ, Lockhart PJ, Riney K, Damiano JA, Hildebrand MS, Mirzaa GM, Dobyns WB, Berkovic SF, Scheffer IE, Tsai JW*, Mefford HC* (2020) Pathogenic variants in CEP85L cause sporadic and familial posterior predominant lissencephaly. Neuron, 106(2):237-245. (* corresponding)
Tsai MH, Cheng HY, Nian FS, Liu C, Chao NH, Chiang KL, Chen SF, Tsai JW* (2020) Impairment in Dynein-Mediated Nuclear Translocation by BICD2 C-terminal Truncation Leads to Neuronal Migration Defect and Human Brain Malformation. Acta Neuropathol Commun, 8(1):106. (* corresponding)
Ibrahim RB, Yeh SY, Lin KP, Ricardo F, Yu TY, Chan CC, Tsai JW*, Liu YT* (2020) Cellular secretion and cytotoxicity of transthyretin mutant proteins underlie late onset amyloidosis and neurodegeneration. Cell Mol Life Sci, 77(7):1421-1434. (* corresponding)
Yang CP, Yang WS, Wong YH, Wang KH, Teng YC, Chang MH, Liao KH, Nian FS, Chao CC, Tsai JW, Hwang WL, Lin MW, Tzeng TY, Wang PN, Campbell M, Chen LK, Tsai TF, Chang PC, Kung HJ (2020) Muscle atrophy‐related myotube‐derived exosomal microRNA in neuronal dysfunction: Targeting both coding and long noncoding RNAs. Aging Cell, 19(5):e13107.
Chang CY, Liang MZ, Wu CC, Huang PY, Chen HI, Yet SF, Tsai JW, Kao CF, Chen L (2020) WNT3A promotes neuronal regeneration upon traumatic brain injury. Int J Mol Sci, 21(4):1463.
Hu CJ, Lu YC, Tsai YH, Cheng HY, Takeda H, Huang CY, Xiao R, Hsu CJ, Tsai JW, Vandenberghe LH, Wu CC, Cheng YF (2020) Efficient in utero gene transfer to the mammalian inner ears by a synthetic adeno-associated viral vector Anc80L65. Mol Ther-Methods & Clin Dev, 18:493-500.
Chang CH, Zanini M, Shirvani H, Cheng JS, Yu H, Feng CH, Mercier AL, Hung SY, cover Forget A, Wang CH, Cigna SM, Lu IL, Chen WY, Leboucher S, Wang WJ, Ruat M, Spassky N, Tsai JW*, Ayrault O* (2019) Atoh1 controls primary cilia formation to allow for SHH-triggered granule neuron progenitor proliferation. Dev Cell, 48(2):184-199.e5. (* corresponding)
Tsai MH, Nian FS, Hsu MH, Liu WS, Liu YT, Liu C, Lin PH, Hwang DY, Chuang YC, Tsai JW* (2019) PRRT2 missense mutations cluster near C-terminus and frequently lead to protein mislocalization. Epilepsia, 60(5):807-817. (* corresponding)
Chen JL, Chang CH, Tsai JW* (2019) Gli2 rescues delays in brain development induced by Kif3a dysfunction. Cereb Cortex, 29(2):751-64. (* corresponding)
Nian FS, Li LL, Cheng CY, Wu PC, Lin YT, Tang CY, Ren BS, Tai CY, Fann MJ, Kao LS, Hong CJ, Tsai JW* (2019) Rab18 collaborates with Rab7 to modulate lysosomal and autophagy activities in the nervous system: An overlapping mechanism for Warburg micro syndrome and Charcot-Marie-Tooth neuropathy type 2B. Mol Neurobiol, 56(9):6095-6105. (* corresponding)
Chang HY, Cheng HY, Tsao AN, Liu C, Tsai JW* (2019) Multiple functions of KBP in neural development underlie brain anomalies in Goldberg-Shprintzen syndrome. Front Mol Neurosci, 12:265. (* corresponding)
Ibrahim RB, Liu YT, Yeh SY, Tsai JW* (2019) Contributions of animal models to the mechanisms and therapies of transthyretin amyloidosis. Front Physiol, 10:338. (* corresponding)
Valente P, Romei A, Fadda M, Sterlini B, Lonardoni D, Forte N, Fruscione F, Castroflorio E, Michetti C, Giansante G, Valtorta F, Tsai JW, Zara F, Nieus T, Corradi A, Fassio A, Baldelli P, Benfenati F (2019) Constitutive inactivation of the PRRT2 gene alters short-term synaptic plasticity and promotes network hyperexcitability in hippocampal neurons. Cereb Cortex, 29(5):2010-2033.
Lu IL, Chen C, Tung CY, Chen HH, Pan JP, Chang CH, Cheng JS, Chen YA, Wang CH, Huang CW, Kang YN, Chang HY, Li LL, Chang KP, Shih YH, Lin CH, Kwan SY, Tsai JW* (2018) Identification of genes associated with cortical malformation using a transposon-mediated somatic mutagenesis screen in mice. Nat Commun, 9(1):2498. (* corresponding)
Hsiao CJ, Chang CH, Ibrahim RB, Lin IH, Wang CH, Wang WJ, and Tsai JW* (2018) Gli2 modulates cell cycle re-entry through autophagy-mediated regulation on the length of primary cilia. J Cell Sci, 131(24). pii: jcs221218. (* corresponding)
Chen YA, Lu IL, Tsai JW* (2018) Contactin-1/F3 regulates neuronal migration and morphogenesis through modulating RhoA activity. Front Mol Neurosci, 11:422. (* corresponding)
Jheng GW, Hur SS, Chang CM, Wu CC, Cheng JS, Lee HH, Chung BC, Wang YK, Lin KH, del Á lamo JC, Chien S, Tsai JW* (2018). Lis1 dysfunction leads to traction force reduction and cytoskeletal disorganization during cell migration. Biochem Biophys Res Commun, 497(3):869-75. (* corresponding)
Kilander MBC, Wang CH, Chang CH, Nestor JE, Herold K, Tsai JW, Nestor MW, Lin YC (2018) A rare human CEP290 variant disrupts the molecular integrity of the primary cilium and impairs Sonic Hedgehog machinery. Sci Rep, 8(1):17335.
Chakraborty S, Karmenyan A, Tsai JW, Chiou A (2017) Inhibitory effects of curcumin and cyclocurcumin in 1-methyl-4-phenylpyridinium (MPP+) induced neurotoxicity in differentiated PC12 cells. Sci Rep, 7(1):16977.
Liu YH, Tsai JW, Chen JL, Yang WS, Chang PC, Cheng PL, Turner DL, Yanagawa Y, Wang TW, Yu JY (2017) Ascl1 promotes tangential migration and confines migratory routes by induction of Ephb2 in the telencephalon. Sci Rep, 7:42895.
Chen HR, Juan HC, Wong YH, Tsai JW, Fann MJ (2017) Cdk12 regulates neurogenesis and late-arising neuronal migration in the developing cerebral cortex. Cereb Cortex, 27(3):2289-302.
Liu YT, Nian FS, Chou WJ, Tai CY, Kwan SY, Chen C, Kuo PW, Lin PH, Chen CY, Huang CW, Lee YC, Soong BW*, Tsai JW* (2016) PRRT2 mutations lead to neuronal dysfunction and neurodevelopmental defects. Oncotarget, 7(26):39184-96. (* corresponding)
Tsai MH, Kuo PW, Myers CT, Li SW, Lin WJ, Fu TY, Chang HY, Mefford HC, Chang YC*, Tsai JW* (2016). A novel DCX missense mutation in a family with X-linked lissencephaly and subcortical band heterotopia syndrome inherited from a low-level somatic mosaic mother: Genetic and functional studies. Eur J Paediatr Neurol, 20(5):788-94. (* corresponding)
Ma L*, Qiao Q*, Tsai JW*, Yang G, Li W, Gan WB (2016) Experience-dependent plasticity of dendritic spines of layer 2/3 pyramidal neurons in the mouse cortex. Dev Neurobiol, 76(3):277-286. (* first author)
Qiao Q, Ma L, Li W, Tsai JW, Yang G, Gan WB (2016) Long-term stability of axonal boutons in the mouse barrel cortex. Dev Neurobiol, 76(3):252-261.
Chakraborty S, Nian FS, Tsai JW, Karmenyan A, Chiou A (2016) Quantification of the metabolic state in cell-model of Parkinson’s disease by fluorescence lifetime imaging microscopy. Sci Rep, 6:19145.
Cheng CY, Wu JC, Tsai JW, Nian FS, Wu PC, Kao LS, Fann MJ, Tsai SJ, Liou YJ, Tai CY, Hong CJ (2015) ENU mutagenesis identifies mice modeling Warburg Micro syndrome with sensory axon degeneration caused by a deletion in Rab18. Exp Neurol, 267:143-51.
Tsai JW & Vallee RB (2011) Live microscopy of neural stem cell migration in brain slices. Methods Mol Biol, 750:131-42. (* first author)
Wang X, Tsai JW, Lamonica B & Kriegstein AR (2011) A new subtype of progenitor cell in the mouse embryonic neocortex. Nat Neurosci, 14(5):555-61. (Cover; featured in News and Views)
Tsai JW*, Lian WN*, Kemal SK, Kriegstein AR & Vallee RB (2010) Kinesin 3 and cytoplasmic dynein mediate interkinetic nuclear migration in neural stem cells. Nat Neurosci, 13(12):1463-71. (* first author)
Wang X, Tsai JW, Imai JH, Lian WN, Vallee RB & Shi SH (2009) Asymmetric inheritance of centrosome maintains neural progenitors during mammalian neocortical neurogenesis. Nature 461(7266):947-55. (Cover; featured in News and Views)
Vallee RB, Seale GE & Tsai JW (2009) Emerging roles for myosin II and cytoplasmic dynein in migrating neurons and growth cones. Trends Cell Biol 19(7):347-55.
Tsai JW, Bremner KH & Vallee RB (2007) Dual subcellular roles for LIS1 and dynein in radial neuronal migration in live brain tissue. Nat Neurosci 10(8):970-9. (* first author)
Vallee RB & Tsai JW (2006) The cellular roles of the lissencephaly gene LIS1, and what they tell us about brain development. Genes Dev 20:1384-93.
Hsieh CF, Chang BJ, Pai CH, Chen HY, Tsai JW, Yi YH, Chiang YT, Wang DW, Chi S, Hsu L & Lin CH (2006) Stepped changes of monovalent ligand-binding force during ligand-induced clustering of integrin IIb3. J Biol Chem 281(35):25466-74.
Tsai JW, Chen Y, Kriegstein AR & Vallee RB (2005) LIS1 RNAi blocks neural stem cell division, morphogenesis, and motility at multiple stages. J Cell Biol 170(6):935-45. (Cover and highlight paper) (* first author)
Hsieh CF, Chang BJ, Pai CH, Chen HY, Chi S, Hsu L, Tsai JW & Chi-Hung Lin (2004) Identification of stepped changes of binding affinity during interactions between the disintegrin rhodostomin and integrin IIb3 in living cells using optical tweezers. Proc SPIE 5514:215-224.
Liu JC, Hwang WL, Chen MS, Tsai JW & Lin CH (2001) Wavelet-based active contour model for object tracking. ICIP Proc 3:206-9.
Tsai JW, Liao BY, Huang CC, Hwang WL, Wang DW, Chiou AE & Lin CH (2000) Applications of optical tweezers and an integrated force measurement module for biomedical research. Proc SPIE 4082:213-21. (Best Student Paper Award) (* first author)
Lian WN, Tsai JW, Yu PM, Wu TW, Yang SC, Chau YP & Lin CH (1999) Targeting of aminopeptidase N to bile canaliculi correlates with secretory activities of the developing canalicular domain. Hepatology 30(3): 748-60.
B. 其他發表
1. 林奇宏、蔡金吾 (2000).「雷射光鉗技術在生物作用力研究上的應用」物理雙月刊 22 卷 5 期, p500-505.