獲獎人簡介 ▞

陳振輝 Chen-Hui Chen, PhD

中央研究院細胞與個體生物學研究所副研究員
歐洲分子生物學組織全球研究學者
115 臺北市南港區研究院路二段 128 號細生所 R640

陳振輝教授現任中央研究院之細胞與個體生物學研究所的副研究員，目前致力於再生醫學及組織發育生物學，陳教授團隊利用斑馬魚作為模式生物，探討脊索動物在附肢再生中關鍵調節因子以及其在機制中所扮演的角色。並且開發了名為「palmskin」的細胞標記技術，使目標細胞會產生不同比例的紅、藍、綠螢光蛋白，讓每一顆細胞都會有不同的顏色組合，以便於研究與追蹤斑馬魚的發育過程。在 2022 年 4 月時發表於《自然》（Nature）的一篇論文，便是以上述技術研究斑馬魚的表皮發育，意外發現除了有絲分裂、減數分裂以外的第三種細胞分裂方式「無合成分裂」（asynthetic fission），為再生醫學、細胞生物學、與發育學開啟了嶄新的康莊大道。

Education 學歷 ▞

美國達特茅斯學院遺傳學博士 2010

國立陽明大學生物化學碩士 2001

國立陽明大學醫學技術學士 1999

Current Position 現職 ▞

中央研究院細胞與個體生物學研究所副研究員 2022 - 迄今

Honors 榮譽獎項 ▞

國科會傑出研究獎 2023
歐洲分子生物學組織全球研究學者 2023
中央研究院前瞻計畫 2019
國科會優秀年輕學者計畫研究補助 2017
Tim Oliver 紀念影像獎，杜克大學細胞生物學系 2015

Research Topics 研究領域 ▞

探討為何只有少數脊索動物（如蠑螈、斑馬魚）具有強大的再生能力。陳教授選用斑馬魚作為模式生物，開發新型的細胞標記技術與影像平台，結合大尺度與多維度的細胞分析行為和遺傳學方法，系統性地分析再生細胞行為及其中的分子機制。最終期望能將研究成果應用在增強人類組織與器官的再生能力。

Publications 學術論文發表 ▞

(標記*為通訊作者)

Chan KY, Yan CCS, Roan HY, Hsu SC, Tseng TL, Hsiao CD, Hsu CP, Chen CH*. “Skin cells undergo asynthetic fission to expand body surfaces in zebrafish” Nature. 2022: 605(7908):119-125. - featured in Nature News & Views, Nature Video, and Developmental Cell.
Osorio-Méndez D, Miller A, Begeman IJ, Kurth A, Hagle R, Rolph D, Dickson AL, Chen CH, Halloran M, Poss KD, Kang J. “Voltage-gated sodium channel, scn8a, is required for innervation and regeneration of amputated adult zebrafish fins” PNAS. 2022: 119(28): e2200342119.
Roan HY, Tseng TL, Chen CH*. “Whole-body clonal mapping identifies giant dominant clones in zebrafish skin epidermis” Development. 2021: 148(18): dev199669. - featured in a special issue: Imaging Development, Stem Cells and Regeneration.
Tseng TL, Wang TY, Tsao CY, Ke YT, Lee YC, Hsu HJ, Poss KD, Chen CH*. “The RNA helicase Ddx52 functions as a growth switch in juvenile zebrafish” Development. 2021:148(15): dev199578. - featured in Development’s Research Highlight.
Wang TY, Tseng TL, Kuo YC, Yu JK, Su YH, Poss KD, Chen CH*. “Genetic reprogramming of positional memory in a regenerating appendage” Current Biology. 2019: 29(24):4193-4207.e4.
Chen CH* and Poss KD*. “Regeneration Genetics” Annual Review of Genetics. 2017: 51:63-82.
Chen CH, Puliafito A, Cox BD, Primo L, Fang Y, Di Talia S, Poss KD. “Multicolor Cell Barcoding Technology for Long-Term Surveillance of Epithelial Regeneration in Zebrafish” Developmental Cell. 2016: 36(6):668-80.
Chen CH, Merriman AF, Savage J, Willer J, Wahlig T, Katsanis N, Yin VP, Poss KD. “Transient laminin beta 1a Induction Defines the Wound Epidermis during Zebrafish Fin Regeneration” PLoS Genetics. 2015: 11(8):e1005437.
Dasgupta A, Chen CH, Lee C, Gladfelter AS, Dunlap JC, Loros JJ. “Biological Significance of Photoreceptor Photocycle Length: VIVID Photocycle Governs the Dynamic VIVID-White Collar Complex Pool Mediating Photo-adaptation and Response to Changes in Light Intensity” PLoS Genetics. 2015: 11(5):e1005215.
Chen CH, Durand E, Wang J, Zon LI, Poss KD. “zebraflash transgenic lines for in vivo bioluminescence imaging of stem cells and regeneration in adult zebrafish.” Development. 2013: 140(24):4988-97.
Hurley JM, Chen CH, Loros JJ, Dunlap JC. “Light-inducible system for tunable protein expression in Neurospora crassa” G3 (Bethesda). 2012: 2(10):1207-12.
Vaidya AT, Chen CH, Dunlap JC, Loros JJ, Crane BR. “Structure of a light-activated LOV protein dimer that regulates transcription in Neurospora crassa” Science Signaling. 2011: 4(184):ra50.
Chen CH, Dunlap JC, Loros JJ. “Neurospora illuminates fungal photoreception” Fungal Genetics and Biology. 2010: 47(11):922-9.
Chen CH, DeMay BS, Gladfelter AS, Dunlap JC, Loros JJ. “Physical interaction between VIVID and white collar complex regulates photoadaptation in Neurospora” PNAS. 2010: 107(38):16715-20.
Froehlich AC, Chen CH, Belden WJ, Madeti C, Roenneberg T, Merrow M, Loros JJ, Dunlap JC. “Genetic and molecular characterization of a cryptochrome from the filamentous fungus Neurospora crassa” Eukaryotic Cell. 2010: 9(5):738-50.
Chen CH, Loros JJ. “Neurospora sees the light: light signaling components in a model system”. Communicative & Integrative Biology. 2009: 448-51.
Chen CH, Ringelberg CS, Gross RH, Dunlap JC, Loros JJ. “Genome-wide analysis of light-inducible responses reveals hierarchical light signalling in Neurospora” EMBO J. 2009: 28(8):1029-42.