answer vs reply
Answer and reply are synonyms- there is a slight nuance in meaning, though (or simply in frequency of collocation and use):
In this example:
A: Can you tell me how to get to the railway station?
B: I'm sorry, I've no idea, I don't live here.
I think B's response is a reply, but not an answer. An answer means A finds out where the station is.
For example you answer the phone, you don't respond or reply.