A short summary of Sheik`s research:

My research focuses on the important role mitochondria play in cell stress responses. My journey into this area began during my PhD studies, where I explored how mitochondrial stress responses are regulated by non-coding RNAs after exposure to foodborne toxins. This foundational work sparked my interest in understanding how mitochondria influence physiological outcomes beyond their traditional role as the cell's "powerhouse."

Currently, my research aims to identify mitochondrial pathways that can be targeted for disease intervention or are dysregulated by foodborne toxins. I am working to scientifically validate the health claims of indigenous plants like Rooibos and Honeybush by investigating their effects on mitochondrial pathways often affected in diseases like diabetes. Additionally, I am exploring the emerging concern of microplastic ingestion and its impact on mitochondrial function and health.
My research ethos is firmly grounded in the adoption of the “3Rs” principle—Replace, Reduce, Refine—for the use of animals. This led me to develop and implement several in vitro models to specifically test the effects of compounds on mitochondrial function and their subsequent implications for metabolic shifts, aberrant generation of reactive oxygen species and inflammation.

Research for Impact is one of the core strategic themes in SU`s Vision 2040. Can you describe the (potential) impact of your research?

My research has both academic and practical applications. Investigating the potential of phytochemicals to target mitochondrial pathways can lead to new nutraceuticals and pharmacological treatments, particularly validating the health benefits of indigenous South African plants. Bridging the gap between basic scientific discoveries and translational applications, my work aims to develop targeted interventions that improve mitochondrial health, offering tangible health benefits and new therapeutic strategies. Additionally, my research supports ethnopharmacology and bioprospecting initiatives, providing more affordable alternatives to conventional treatments.
My research on the impact of microplastics on mitochondrial function addresses a pressing environmental and emerging public health concern. Understanding the specific mechanisms through which microplastics induce mitochondrial dysfunction is crucial for comprehensively assessing their health effects. My work seeks to identify biomarkers for mitochondrial toxicity and elucidate the pathways leading to mitochondrial damage. This information can inform risk assessment and regulatory policies, guiding efforts to reduce human and environmental exposure to microplastics. Ultimately, this research contributes to a deeper understanding of the interconnectedness between environment and health.

In the ever-changing environment of academia, what are some of the obstacles early career researchers are faced with?

As a young academic, I can relate to the numerous obstacles early career researchers face. Securing funding is a formidable obstacle, with intense competition against established researchers who possess extensive track records and networks making it difficult. Additionally, balancing multiple responsibilities, including teaching, mentoring, administrative duties, and research, presents a substantial challenge. The demands of these tasks can lead to a sense of overwhelm and detract from research productivity. Moreover, building a professional network is essential for collaboration and career advancement, yet establishing connections can be daunting for newcomers with limited contacts.

What would you regard as the most important aspects to consider to effectively support early career researchers?

Accessible funding for the early career stage is vital, this will help kick-start projects and build a credible research portfolio. I also think that advice on balancing teaching, research, and administrative duties through mentorship is important for navigating the academic environment.

What excites you about your work? 

What excites me about my research is the potential to make significant contributions to both science and society. My work on mitochondrial toxicology and pharmacology offers a unique perspective on the crucial role of mitochondria beyond their traditional function as cellular powerhouses. I am particularly driven by the opportunity to reshape our understanding of mitochondrial function in cell stress responses and its implications for human health. The prospect of driving innovation, advancing scientific knowledge, and making tangible contributions to human health makes my research fulfilling.

When you're not in the lab, library or in the field conducting research, what do you do to unwind?

One of my favourite pastimes is hiking. Exploring the beautiful landscapes around Stellenbosch and Cape Town provides a refreshing break from the demands of academia and allows me to stay active. Another activity I find relaxing is gardening, which allows me to connect with nature in a different way and provides a sense of accomplishment. I enjoy cultivating various plants, including indigenous South African species.

How has the ECAD programme of SU contributed to your research career? 

The ECAD programme has been instrumental in advancing my research career. One of the most significant contributions has been the mentorship opportunities it offers. Through ECAD, I have been able to connect with an experienced academic who provides invaluable guidance and advice, helping me navigate the challenges of academia. They did a wonderful job in matching me up with someone who is willing to share their institutional and historical knowledge of SU which helped me settle in.
Additionally, the programme has provided crucial funding to visit an overseas collaborator. These visits have allowed me to establish and strengthen international research partnerships, facilitating the exchange of ideas and enhancing the quality of my research.
The support for conference attendance provided by ECAD has also been a major benefit. Because of this funding I can share my work to the broader scientific community, receive feedback, and stay updated on the latest developments in my field.
These experiences have not only enriched my research but also expanded my professional network, opening up further opportunities for collaboration and funding.

What advice, if any, would you look to impart to future early career academics?

"Eat the elephant one bite at a time." When faced with large, daunting tasks or projects, break them down into smaller, manageable steps. This approach helps to avoid feeling overwhelmed and makes it easier to make consistent progress. 

Connect with Sheik and his work!

https://www.sun.ac.za/english/faculty/science/biochemistry/Pages/Abdul-Group.aspx
Google Scholar: https://scholar.google.com/citations?user=FvTQa98AAAAJ&hl=en
Research Gate: https://www.researchgate.net/profile/Naeem-Sheik-Abdul