Identifying Data Sets

Team 1

This team identified all the Drosophila melanogaster genes with human orthologs. We are only interested in looking at conserved genes. We used Flybase to create this list.

Team 2

This team worked to identify lists of genes known to be expressed in neurons or in glial cells of the Drosophila brain. Our data sets compare the levels of glia to neurons throughout the brain. Link to paper from which data was taken: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224204/ 

Team 3

Study: https://www.nature.com/articles/s41598-020-74748-9#Sec17 

Data: https://static-content.springer.com/esm/art%3A10.1038%2Fs41598-020-74748-9/MediaObjects/41598_2020_74748_MOESM5_ESM.txt  

This study shows over-expressed AB42 in flies to figure out which gene expressions change significantly compared to a control group. They identified 228 and 720 respectively. However, there was surprisingly little correlation between the two lists.


Team 4:

https://flybase.org/

We used FlyBase predominately to find wild-type fly gene sets. First, we looked for a complete list of the wild-type fly genome on MCBI & Pubmed relating to the amyloid-beta protein. When that was not easily found, we compiled all of the lists of genes that were found in parts of the neuron (membrane, nucleus, ER, Golgi apparatus, etc.) and created our own unprocessed, comprehensive list to pass onto another team.