The Basic Science Research Program (BSRP) focuses on defining prostate cancer-specific molecular alterations that would lead to better understanding of the causes of prostate cancer in US military service members. Prostate cancer gene discovery and biology focused research efforts are complemented by collaborations from the CPDR's Clinical Research and Multicenter National Database programs, accelerating evaluations of new biomarkers and therapeutic targets with potential in enhancing the management of prostate cancer.
Discovery of frequent and potentially causal prostate cancer gene alterations using cutting edge technologies and well annotated and precisely processed bio-specimens
Evaluation of cancer biology of prostate cancer relevant genes or proteins using established and new experimental models
Development of new molecular strategies for improving prostate cancer diagnosis (more cancer specific markers than PSA) and prognosis
Delineation of hormonal mechanisms involved in prostate cancer onset or progression
Development and evaluation of novel molecular therapeutic agents for prostate cancer
Identification of molecular determinants of prostate cancer susceptibility in high-risk groups
Development and maintenance of long-term molecular specimen resources for translational investigations at CPDR and collaborations at other institutions
Education and training of next generation of basic science and translational researchers in prostate cancer
Education and training of medical and graduate students, post-doctoral fellows, residents and visiting scientists in prostate cancer research
Two of the major activities of the BRP research program include investigator-initiated research and development of unique bio-resources critical for research at CPDR and in the prostate cancer field