Osteoarthritis - nf-kappab is a big player. Reishi is shown to be able to reduce nf-kappab.
NF-κB as a potential therapeutic target in osteoarthritis and rheumatoid arthritis
http://www.sciencedirect.com/science/article/pii/S1063458406001105
The NF-κB signalling pathway in osteoarthritis
http://www.sciencedirect.com/science/article/pii/S1357272513002860
NF-κβ signaling and chronic inflammatory diseases: exploring the potential of natural products to drive new therapeutic opportunities
http://www.sciencedirect.com/science/article/pii/S1359644613003966