Cancer

Effects of a water-soluble extract of Ganoderma lucidum mycelia on aberrant crypt foci induced by azoxymethane and small-intestinal injury by 5-FU in F344 rats.

http://www.ncbi.nlm.nih.gov/pubmed/23338779

A water-soluble extract from cultured medium of Ganoderma lucidum (Reishi) mycelia attenuates the small intestinal injury induced by anti-cancer drugs.

http://www.ncbi.nlm.nih.gov/pubmed/22966257

Protective effects of a water-soluble extract from cultured medium of Ganoderma lucidum (Rei-shi) mycelia and Agaricus blazei murill against X-irradiation in B6C3F1 mice: Increased small intestinal crypt survival and prolongation of average time to animal death.

http://www.ncbi.nlm.nih.gov/pubmed/15702228

Reishi -

Enhanced immune recognition of cryptic glycan markers in human tumors.

http://www.ncbi.nlm.nih.gov/pubmed/19223535

Studies on the immuno-modulating and antitumor activities of Ganoderma lucidum (Reishi) polysaccharides: functional and proteomic analyses of a fucose-containing glycoprotein fraction responsible for the activities.

http://www.ncbi.nlm.nih.gov/pubmed/11836115

The anti-tumor effect of Ganoderma lucidum is mediated by cytokines released from activated macrophages and T lymphocytes.

http://www.ncbi.nlm.nih.gov/pubmed/9096652

Medicinal mushroom Lingzhi or Reishi, Ganoderma lucidum (W.Curt.:Fr.) P. Karst., beta-glucan induces Toll-like receptors and fails to induce inflammatory cytokines in NF-kappaB inhibitor-treated macrophages.

http://www.ncbi.nlm.nih.gov/pubmed/22135873

Ganoderma lucidum polysaccharides enhance the function of immunological effector cells in immunosuppressed mice.

http://www.ncbi.nlm.nih.gov/pubmed/17182202

Reishi Adjuvant

A novel adjuvant Ling Zhi-8 enhances the efficacy of DNA cancer vaccine by activating dendritic cells

http://link.springer.com/article/10.1007/s00262-011-1016-4#page-1

Immunomodulatory and adjuvant activities of a ...

F3 - fucose - extracted from reishi

Taiwan researchers unlock reishi mushroom's cancer-fighting secret

http://focustaiwan.tw/news/ast/201308300020.aspx

Immunomodulatory and adjuvant activities of a polysaccharide extract of Ganoderma lucidum in vivo and in vitro.

http://www.ncbi.nlm.nih.gov/pubmed/20653103

Molecular basis for the effects of an herbal supplement - F3

http://www.pnas.org/content/110/34/13693.full.pdf

Immunization of fucose-containing polysaccharides from Reishi mushroom induces antibodies to tumor-associated Globo H-series epitopes.

http://www.ncbi.nlm.nih.gov/pubmed/23908400

Globo - H

Glycan microarray of Globo H and related structures for quantitative analysis of breast cancer

http://www.pnas.org/content/105/33/11661.full

Trial of Active Immunotherapy With Globo H-KLH (OPT-822) in Metastatic Breast Cancer Subjects

http://clinicaltrials.gov/show/NCT01516307

Broken Spores from reishi

Comparison of the immunomodulatory effects of spore polysaccharides and broken spore polysaccharides isolated from Ganoderma lucidum on murine splenic lymphocytes and peritoneal macrophages in vitro].

http://www.ncbi.nlm.nih.gov/pubmed/16378103

Antitumor and Immunomodulatory Effects of Polysaccharides from Broken-Spore of Ganoderma lucidum.

http://www.ncbi.nlm.nih.gov/pubmed/22811667

Patent to get F3 from reishi

Reishi F3 sub fraction polysaccharides and methods of using same

http://www.google.de/patents/US8071105

Administering a polysaccharide or glycopeptide component having terminal fucose residues with alpha 1,2-fucosidic linkages; increasing hematopoietic activity

https://www.google.com/patents/US7560114

Have to figure out who sells or how to make F3

stanford to have a clinical trial in 2014 - for cd47 vaccine...

CD47 - looks to be over expressed on cancer cells.

http://stemcell.stanford.edu/CD47/

http://med.stanford.edu/ism/2013/may/cd47.html

Reishi Allergies

http://www.ncbi.nlm.nih.gov/pubmed/21698671

http://www.ncbi.nlm.nih.gov/pubmed/21612588

http://www.ncbi.nlm.nih.gov/pubmed/14723251

http://www.ncbi.nlm.nih.gov/pubmed/22569041

http://www.ncbi.nlm.nih.gov/pubmed/17606977

http://www.ncbi.nlm.nih.gov/pubmed/24266379

Out of all the things studies I have been researching, things that I found interesting and wish i could experiment on:

1) Applying heat to where a tumor is.

This makes sense, since the opens up the blood vessels. There are several places doing studies on this.

2) Giving chemo drugs at body temperature instead of room temperature

Again, blood vessels are opened up

3) Fevers

I was researching spontaneous remission and one common trait was prolonged fever. I was think about why we get fevers? I think this is the a way to alert every cell in the body to go into attack mode. Apparently the cells make different proteins when they are hot. I think fevers are a way to communicate quickly to every cell in the body. And Cancer cells can not adapt.

4) Light

when exposed to light, the cells again make up different proteins. Don't know why someone has not made a device battery operated, in pill form that people could swallow and shine a light for cancers in the digestive track.

5) Cancer cells can not adapt

Light, temperature, ph, food restriction.

6) Prostatic Arteria Embolisation

Could we not do this for certain tumors? Cut off there blood supply?

7) Bacteria/Fungi in intestines

I think some cancers is caused by bacteria/fungus in the intestines. I have heard that fecal transplants are helping diabetic patients. If this is true, then we should try doing fecal transplant on people with pancreatic cancer to see if this helps?

8) Bicarbonate

I read the older we get the less bicarbonate our pancreas excretes. I also read that the pancreas gets the bicarbonate from the plasma( (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1395641/ ). Have we studied to see what happens to cancer patients when bicarbonate is increased? From what I understand, tumors are acid producing and majority of the bacteria found in the intestines love lower ph. I would be curious to see if increase in bicarbonate changes the flora in the pancreas and duct. This could be is a simple way to keep out bacteria from the pancreas, and keep the ducts clear?

9) Chemo + Bicarbonate

Could we not bind chemo drugs to the bicarbonate? The drugs could get inside the pancreas.

I think pancreatic cancer could be caused because of bacteria, fungus. There has been some studies showing that patients have bacteria in the pancreas, where controls had none. Why is bacteria getting in there? Is the environment acidic because the pancreas is not making enough bicarbonate?

8) Bicarbonate

Pancreas excretes bicarbonate - which is gets from the plasma. Could we not bind chemo drugs to bicarbonate? Here is an article talking about where pancreas gets most of its bicarbonate. ( http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1395641/ )

http://www.ncbi.nlm.nih.gov/pubmed/6992944

http://www.anaesthesia.med.usyd.edu.au/resources/lectures/acidbase_mjb/causes.html

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