Reishi -> known to down regulate nf-kappab.
Colon cancer - looks like there is an upregulation of nf-kappab
NF-kappaB
Targeting NF-kappaB for colorectal cancer.
http://www.ncbi.nlm.nih.gov/pubmed/20367537
Colorectal cancer and NF-κB signaling pathway.
http://www.ncbi.nlm.nih.gov/pubmed/24834170
Triterpenes From Ganoderma Lucidum Induce Autophagy in Colon Cancer Through the Inhibition of p38 Mitogen-Activated Kinase (p38 MAPK)
http://www.tandfonline.com/doi/abs/10.1080/01635580903532390#.U6mbX5RdUic
Constitutive NF-KB Activation in Colorectal Carcinoma Plays a Key Role in Angiogenesis, PromotingTumor Growth
http://clincancerres.aacrjournals.org/content/15/7/2248.full.pdf
Mutant p53 Prolongs NF-κB Activation and Promotes Chronic Inflammation and Inflammation-Associated Colorectal Cancer
http://www.cell.com/cancer-cell/abstract/S1535-6108(13)00130-X
Grape Seed Extract
Grape seed promise in fight against bowel cancer
http://www.sciencedaily.com/releases/2014/02/140214092004.htm
Here are different studies...
Grape Seed Extract Effective In Colorectal Cancer Treatment
http://www.medicalnewstoday.com/articles/255182.php
Grape seed extract induces cell cycle arrest and apoptosis in human colon carcinoma cells.
http://www.ncbi.nlm.nih.gov/pubmed/19003575
Grape seed extract triggers apoptosis in Caco-2 human colon cancer cells through reactive oxygen species and calcium increase: extracellular signal-regulated kinase involvement.
http://www.ncbi.nlm.nih.gov/pubmed/23433299
Differential effect of grape seed extract against human non-small-cell lung cancer cells: the role of reactive oxygen species and apoptosis induction.
http://www.ncbi.nlm.nih.gov/pubmed/23682782
Toxicity - looks to be ok?
Subchronic 3-month oral toxicity study of grape seed and grape skin extracts.
http://www.ncbi.nlm.nih.gov/pubmed/12419686
Safety evaluation of proanthocyanidin-rich extract from grape seeds.
http://www.ncbi.nlm.nih.gov/pubmed/11955665
90-day oral toxicity study of a grape seed extract (IH636) in rats.
http://www.ncbi.nlm.nih.gov/pubmed/11902976
Acute and long-term safety evaluation of a novel IH636 grape seed proanthocyanidin extract.
http://www.ncbi.nlm.nih.gov/pubmed/11758648
Clinical Trial
http://clinicaltrials.gov/ct2/show/NCT00566553
i would be curious what the results of this trial was...
http://clinicaltrials.gov/ct2/show/record/NCT00566553
Mushroom Ganoderma lucidum prevents colitis-associated carcinogenesis in mice.