過去の成果 (2015~2013)

2015

5. Komatsu N, Fujita Y, Matsuda M, Aoki K.

mTORC1 upregulation via ERK-dependent gene expression change confers intrinsic resistance to MEK inhibitors in oncogenic

KRas- mutant cancer cells.

Oncogene 2015 Nov 5;34(45):5607-16. doi: 10.1038/onc.2015.16.

4. Komatsubara AT, Matsuda M, Aoki K.

Quantitative analysis of recombination between YFP and CFP genes of FRET biosensors introduced by lentiviral or retroviral

gene transfer.

Sci Rep. 2015 Aug 20;5:13283. doi: 10.1038/srep13283.

3. Goto A, Nakahara I, Yamaguchi T, Kamioka Y, Sumiyama K, Matsuda M, Nakanishi S, Funabiki K.

Circuit-dependent striatal PKA and ERK signaling underlies rapid behavioral shift in mating reaction of male mice.

Proc Natl. Acad. Sci. U.S.A. 2015 May 11. doi: 10.1073/pnas.1507121112.

2. Hiratsuka T, Fujita Y, Naoki H, Aoki K, Kamioka Y, Matsuda M.

Intercellular propagation of extracellular signal-regulated kinase activation revealed by in vivo imaging of mouse epidermis.

eLife 2015 Feb 10;4:e05178. doi: 10.7554/eLife.05178.

1. Imajo M, Ebisuya M, Nishida E.

Dual role of YAP and TAZ in renewal of the intestinal epithelium.

Nature Cell Biol. 2015 Jan;17(1):7-19. doi: 10.1038/ncb3084.

2014

6. Sadaie W, Harada Y, Matsuda M, Aoki K.

Quantitative in vivo fluorescence cross-correlation analyses highlight the importance of competitive effects in the regulation of

protein-protein interactions.

Mol Cell Biol. 2014 Sep;34(17):3272-90.

5. Fujita Y, Komatsu N, Matsuda M, Aoki K.

FRET-based quantitative analysis of feedforward and feedback loops in EGFR signaling and the sensitivity to molecular

targeting drugs.

FEBS J. 2014 May 21. doi: 10.1111/febs.12852.

4. Mizuno R, Kamioka Y, Kabashima K, Imajo M, Sumiyama K, Nakasho E, Ito T, Hamazaki Y, Okuchi Y, Sakai Y, Kiyokawa E, Matsuda M.

In vivo imaging reveals PKA regulation of ERK activity during neutrophil recruitment to inflamed intestines.

J Exp Med. 2014 May 19. doi: 10.1084/jem.20132112

3. Kumagai Y, Naoki H, Nakasyo E, Kamioka Y, Kiyokawa E, Matsuda M.

Heterogeneity in ERK activity as visualized by in vivo FRET imaging of mammary tumor cells developed in MMTV-Neu mice.

Oncogene 2014 Mar 17. doi: 10.1038/onc.2014.28.

2. Yukinaga H, Shionyu C, Hirata E, Ui-Tei K, Nagashima T, Kondo S, Okada-Hatakeyama M, Naoki H, Matsuda M.

Slow fluctuation of Rac1 activity is associated with biological and transcriptional heterogeneity of glioma cells.

J Cell Sci. 2014 PMID: 24522191

1. Miura H, Matsuda M, Aoki K.

Development of a FRET biosensor with high specificity for Akt.

Cell Struct Funct. 2014 Jan 8;39(1):9-20

2013

5. Aoki K, Kumagai Y, Sakurai A, Komatsu N, Fujita Y, Shionyu C, Matsuda M.

Stochastic ERK Activation Induced by Noise and Cell-to-Cell Propagation Regulates Cell Density-Dependent Proliferation.

Mol Cell. 2013 Nov 21;52(4):529-40.

4. Aoki K, Takahashi K, Kaizu K, Matsuda M.

A Quantitative Model of ERK MAP Kinase Phosphorylation in Crowded Media.

Sci Rep. 2013;3:1541.

3. Goto A, Sumiyama K, Kamioka Y, Nakasyo E, Ito K, Iwasaki M, Enomoto H, Matsuda M.

GDNF and Endothelin 3 Regulate Migration of Enteric Neural Crest-Derived Cells via Protein Kinase A and Rac1.

J Neurosci.2013;33(11):4901-4912.

2. Aoki K, Kamioka Y, Matsuda M.

Fluorescence resonance energy transfer imaging of cell signaling from in vitro to in vivo: Basis of biosensor construction, live

imaging, and image processing.

Dev Growth Differ. 2013 Feb 7.

1. Mori Y, Yagi S, Sakurai A, Matsuda M, Kiyokawa E.

Insufficient ability of Rac1b to perturb cystogenesis.

Small GTPases. 2013;4(1):9-15.