Program

5:30-6:20pm Registration and Dinner

6:20pm Gastric Electrophysiology: Measurement and Modelling (Chairs: Ken Koch, MD and Xiaohua Hou, MD, PhD)

6:20-6:28: Is the Electrogastrogram a Clinically Useful Tool?

Shifat Ahmed (2), Steven Ramos (2), Chirag M. Patel (2), Munish Ashat (3), Lindsay McElmurray (5), Michael Hughes (2), Ed Miller (2), Abigail Stocker (2), Christina Pinkston (2), Guy Brock (2), Chris Lahr (4), Thomas L. Abell *(1), 1. Digestive Diseases, University of Louisville, Louisville, KY, 2. University of Louisville, Louisville, KY, 3. John H. Stroger Hospital, Chicago, IL, 4. University of Mississippi, Jackson, MS, 5. University of Louisville Physicians, Louisville, KY, United States

6:28-6:36: The emergent properties of ICC networks and multiple network interactions

JD Huizinga, McMaster University, Hamilton, Ontario, Canada

6:36-6:44: Quantification of the Anisotropic Ratio of Gastric Tissue Conductivities: Methods and Application

Peng Du, Niranchan Paskaranandavadivel, Shameer Sathar, Timothy R. Angeli, Gregory O’Grady, Leo K. Cheng, Auckland Bioengineering Institute, University of Auckland, New Zealand

6:44-6:52 High-density electrogastrogram identifies spatial dysrhythmias in adolescent patients with chronic idiopathic nausea: a preliminary study

ND Muszynski *(1,5), S Somarajan (1,5), AC Russell (3), S Acra (3), LK Cheng (4,1), LA Bradshaw (1,2,5), 1. Department of General Surgery, Vanderbilt University School of Medicine, Nashville, TN; 2. Department of Physics and Astronomy, Vanderbilt University, Nashville, TN; 3. Department of Pediatric Gastroenterology, Monroe Carell Jr. Children's Hospital, Nashville, TN; 4. Auckland Bioengineering Institute, Auckland University, Auckland, New Zealand; 5. Vanderbilt Institute for Integrative Biosystems Research and Education, Vanderbilt University, Nashville, TN, USA

6:52-7:00 Electrogastrography Determines Subtypes of Gastroparesis Responsive to Pyloric Balloon Dilation: Functional Gastric Outlet Obstruction

(Young Investigator Award)

Patrick Squires*(1), MD Noar (2), (1) University of Pittsburgh, School of Pharmacy, Pittsburgh, PA, (2) Center for Reflux and Motility Disorders, Towson, MD

7:00-7:08 Hemodialysis improves upper gastrointestinal symptoms and gastric slow waves by increasing plasma ghrelin and suppressing plasma GLP-1 in patients with chronic kidney disease

(Young Investigator Award)

Gao-jue Wu *(1,3,4), Xu-dong Cai (2), Jie Xing (2), Gang-hui Zhong (2), Jiande DZ Chen (3,5), 1. Division of Gastroenterology, Wuxi No.2 Hospital affiliated to Nanjing Medical University, Wuxi 214002, China; 2. Division of Nephrology, Ningbo TCM Hospital, Ningbo315000, China; 3. Ningbo Pace Translational Medical Research Center, Beilun, Ningbo 315000, China; 4. Division of Gastroenterology, Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China 5. Division of Gastroenterology and Hepatology, Johns Hopkins Medicine, Baltimore, MD 21224

7:10pm Electrical Therapies along the Gut: Basic and Clinical (Chairs: Henry Parkman, MD and Jieyun Yin, MD)

7:10-7:18 Study on Effects of Electrical Stimulation on Rabbit Esophageal Body Motility in Vivo Electrical Stimulation on Esophageal Motility

Lili Zhang, Wei Zhao, Chunshan Zhao, Hong Jin, Qi Yao, Guojian Zhou, Bangmao Wang, Department of Digestive Diseases, General Hospital, Tianjin Medical University, Tianjin, China

7:18-7:26 Gastric ablation as a novel therapeutic technique for modulating gastric slow wave activity

TR Angeli *(1), MJ Herrera (1), P Du (1), N Paskaranandavadivel (1), S Amirapu (2), A Beyder (4), SJ Asirvatham (3), G Farrugia (4), LK Cheng (1,5), G O’Grady (1,6), (1) Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand; (2) Department of Anatomy, University of Auckland, Auckland, New Zealand; (3) Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, MN; (4) Departments of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN; (5) Department of Surgery, Vanderbilt University, Nashville, TN; (6) Department of Surgery, University of Auckland, Auckland, New Zealand

7:26-7:34 The role of Toll-like receptor 4 and mast cell function in the ameliorating effect of electroacupuncture on visceral hypersencitivity in rats

Juan Yang, Haitao Shi, Shanshan Zhu, Lijuan Mao, Xiaomeng Cui, Fei Dai, Department of Gastroenterology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi’an, China

7:34-7:42 Medium and Long Term Outcome of Symptoms using Gastric Electrical Stimulation with Temporary GES as a Screening Tool

Imad Jaafar (2), Endashaw Omer (2), Hammad Liaquat(2), Abigail Stocker (1), Lindsay McElmurray (3), Siva R. Cheetirala (2), Malathi L. Perugula (2), Michael Hughes (2), Ed Miller (2), Thomas L. Abell *(1), 1. Digestive Diseases, University of Louisville, Louisville, KY; 2. University of Louisville, Louisville, KY; 3. University of Louisville Physicians, Louisville, KY, United States

7:42-7:50 Efficacy of Needleless Transcutaneous Electroacupuncture in Synchronization with Breathing for Symptomatic Idiopathic Gastroparesis: a Blinded and Controlled Acute Treatment Trial

GQ Song *(1), Y Sun (1), A Quezada (1), M Bashashadi (1), I Sarosiek (1), JD Chen (2), RW McCallum (1), 1. Internal Medicine Department, Texas Tech University Health Sciences Center, Paul L. Foster School of Medicine, El Paso, TX 79905; 2. Division of Gastroenterology and Hepatology, Johns Hopkins Center of Neurogastroenterology, Baltimore, MD, USA

7:50-7:58 Obstructive Gastroparesis: Effect of laparoscopic pyloroplasty on symptoms, gastric emptying and gastric myoelectrical activity after successful endoscopic pyloric therapies

(Alvarez Award for Best Abstract).

JL Wellington* (1), KL Koch (2), PA Stuart (2), (1) Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, (2) Gastroenterology, Wake Forest School of Medicine, Winston-Salem, NC, United States

7:58-8:06 Effects and mechanisms of the subdiaphragmatic vagus nerve stimulation on the postoperative ileus in a rodent model

(Robert Stern Young Investigator Award).

Haruaki Murakami (1, 2, 4), Shiying Li (1, 2), Jieyun Yin (1), Jiande DZ Chen (1, 3), 1. Veterans Research and Education Foundation, VA Medical Center, OK; 2. Department of Physiology, University of Oklahoma, OK; 3. Division of Gastroenterology and Hepatology, Johns Hopkins University, Baltimore, MD; 4 Department of Digestive Surgery, Kawasaki Medical School Japan

8:06-8:14 Chronic intestinal electrical stimulation improves glucose intolerance and insulin resistance in diet-induced obesity rats

Shiying Li *(1), Weijian Zhu (1,3), Jiande Chen(2), (1) Veterans Research and Education Foundation, VA Medical Center, Oklahoma City, OK; (2) Division of Gastroenterology and Hepatology, Johns Hopkins University, Baltimore, MD, USA; (3) Jiangsu Province Hospital, Nanjing, China

8:14-8:22 Sacral nerve stimulation with optimized parameters improves constipation in rats by enhancing colon motility mediated via the autonomic mechanisms.

Zhihui Huang* (1, 2, 4), Shiying Li (1), Robert D. Foreman (3), Jieyun Yin (1,4), Ning Dai (2), Jiande DZ Chen (1, 4). (1) Veterans Research and Education Foundation, VA Medical Center, Oklahoma City, OK, USA, (2) Department of Gastroenterology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China, (3) University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA, (4) Johns Hopkins Center for Neurogastroenterology, Johns Hopkins University, Baltimore, USA

8:22-8:30 A Miniature Wireless Gastric Stimulator for High Energy Stimulation

(Young Investigator Award)

R Wang (1), N Paskaranandavadivel (2), S Sathar (2), P Du (2), TR Angeli (2), G O'Grady (2), M Kiani (3), LK Cheng (2), A Farajidavar *(1), (1) Electrical and Computer Engineering, New York Institute of Technology, Old Westbury, NY; (2) Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand; (3) Electrical Engineering, Pennsylvania State University, University Park, PA, United States

8:35-8:45 Awards (Richard McCallum, MD and Jiande Chen, PhD)

8:45-9:00 Break

9:00pm Measurements and Therapies (Short Presentations) (Chairs: Thomas Abell, MD and Leo Cheng, PhD)

9:00-9:04 Peroral Endoscopic Myotomy Better than Pneumatic Dilation: More Complete Relaxation of Lower Esophageal Sphincter

Wei Zhao, Zhongqing Zheng, Haiying Guo, Lili Zhang, Tao Wang, Bangmao Wang, Wentian Liu, Department of Digestive Diseases, General Hospital, Tianjin Medical University, Tianjin, China

9:04-9:08 Comparison of Neurohormonal Changes with Gastroparesis in Response to Temporary Gastric Electrical Stimulation

Shifat Ahmed (2), Nanlong Liu (2), Nikhil Kadle (2), Chirag M. Patel (2), Munish Ashat (4), Abigail Stocker (1), Lindsay McElmurray (3), Michael Hughes (2), Karen Beatty (1), Keith C. Falkner (2), Archana Kedar (1), Thomas L. Abell *(1), 1. Digestive Diseases, University of Louisville, Louisville, KY, United States, 2. University of Louisville, Louisville, KY, United States, 3. University of Louisville Physicians, Louisville, KY, United States, 4. John H. Stroger Hospital, Chicago, IL, United States

9:08-9:12 Ameliorating Effects of Transcutaneous Electrical Acustimulation (TEA) on Functional Dyspepsia

Yihong Fan (1), Wei Zhao (2), Fang Yao (1), Chunshan Zhao (2), Lina Meng (1), Bingbing Wang (2), Lanlan Wu (2), Bin Lu (1), Bangmao Wang *(2), 1. Division of

Gastroenterology, Zhejiang Provincial Hospital of TCM, Hangzhou, China; 2. Division of Tianjin Medical University General Hospital,Tianjin, China

9:12-9:16 Clinical Outcome of Diabetic Versus Idiopathic Gastroparesis Undergoing Gastric Electrical Stimulation

Ammar Hassan (2) Abigail Stocker (1), Lindsay McElmurray (4), Karen Beatty (1), Michael Hughes (2), Christina Pinkston (2), Guy Brock (2), Hani Rashed (3), Archana Kedar

(1), Thomas L. Abell *(1), 1. Digestive Diseases, University of Louisville, Louisville, KY; 2. University of Louisville, Louisville, KY; 3. Methodist Hospital, Memphis, TN; 4. University of Louisville Physicians, Louisville, KY, United States

9:16-9:20 Emergent properties of the intestinal pacemaker network: mathematical modelling to understand effects of frequency noise, coupling strength and loss of pacemakercells

R Wei (1), SP Parsons (2) and JD Huizinga* (2), 1. Hillfield Strathallan College, Hamilton ON Canada, 2. McMaster University, Hamilton ON Canada

9:20-9:24 Energy of Gastric Electrical Stimulation Interacts with Cajal, Mast and S100 Cells to Predict GI Symptom Outcome

Nikhil Kadle (2), Christina Pinkston (2), Guy Brock (2), Xiu Yang (2), Abigail Stocker (1), Lindsay McElmurray (3), Angel Munoz (2), Siva R Cheetirala (2), Malathi L Perugula (2), Michael Hughes (2), Mostafa Fraig (2) Warren Starkebaum (4), Thomas L. Abell *(1), 1. Digestive Diseases, University of Louisville, Louisville, KY; 2. University of Louisville, Louisville, KY; 3. University of Louisville Physicians, Louisville, KY; 4. Starkebaum and Associates, Minneapolis, MN, United States.

9:24-9:28 Therapeutic effect of acute transcutaneous electroacupuncture on gastroesophageal reflux disease

Ying Wang (1), Lin Lin (2), Meifeng Wang (2), Jianchao Ge (2), Xiufang Cui (1), Jiande D Z Chen *(3), 1. Jiangsu Province Geriatric Hospital, China, 2. The First Affiliated Hospital of Nanjing Medical University, China, 3. John Hopkins University, Baltimore, MD, USA

9:28-9:32 The Effect of Gastrointestinal Electrical Stimulation in Patients with The Symptoms of Gastroparesis Combined With Pancreato-Biliary Disorders

Patrick McKenzie (2), Abigail Stocker (1), Lindsay McElmurray (3), Endashaw Omer (2), Michael Hughes (2), Thomas L. Abell *(1), 1. Digestive Diseases, University of Louisville, Louisville, KY; 2. University of Louisville, Louisville, KY; 3. University of Louisville Physicians, Louisville, KY, United States

9:32-9:36 Model Recovery phase mapping of slow waves in high-resolution

N Paskaranandavadivel *(1), P Du (1), J Rogers (2), G O’Grady (1), LK Cheng (1,3), 1. Auckland Bioengineering Institute, University of Auckland, New Zealand; 2. Department

of Biomedical Engineering, University of Alabama at Birmingham, AL, USA; 3. Department of Surgery, Vanderbilt University, Nashville, TN, USA

9:36-9:40 Autonomic And Enteric Responses to Temporary Gastric Electrical Stimulation

Andy Patel (2), Samir Vermani (2), Ed Miller (2), Karen Beatty (1), Abigail Stocker (1), Michael Hughes (2), Hani Rashed (3), Archana Kedar (1), Thomas L. Abell *(1), 1. Digestive Diseases, University of Louisville, Louisville, KY; 2. University of Louisville, Louisville, KY; 3. Methodist Hospital, Memphis, TN, United States

9:40-9:44 Development of Rhythm.IC: A new medical device for transabdominal electrical stimulation to increase bowel motility

Southwell BR (1,2)*, Tan AF (1,2), Hutson JM (1,2,3), (1) Murdoch Childrens Research Institute, Melbourne; (2) Dept of Paediatrics, University of Melbourne, Vic; (3) Dept of Urology, Royal Children’s Hospital, Melbourne, Australia

9:44-9:48 Correlations of the Severity of Dyspepsia Symptoms with Electrogastrography, Quality of Life and Psychological Distress: A Nested Cross-Sectional Study of Functional Dyspepsia Patients

WJ Wang* (1), KKL Wong (1), J Zhou (1), M Zhu (2), B Marjadi (1), B McHutchison (1), G O'Grady (3), V Ho (1).

10:00pm Adjourn