王涵青 (Wang, Han-Ching)

學術榮譽及獎項

1. 籌備科技部補助國內舉辦國際學術研討會”第13屆亞洲漁業和水產養殖論壇”

2. 第九屆星雲教育獎「典範教師獎」(2021)

3. 國立成功大學創新與大學社會責任之教學優良獎(2020)

4. 科技部108年度大專學生參與專題計畫研究創作獎 (2020)

5. 國家農業科學獎之前瞻創新類千里馬獎 (2019)

6. 科技部吳大猷紀念獎研究計畫 (2019)

7. 世界科學院年輕學者 (2018)

8. 第11屆「台灣傑出女科學家獎」新秀獎 (2018)

9. 科技部105年「吳大猷先生紀念獎 (2016)

10. 104學年度「李國鼎科技與人文講座」研究獎 (2015)

11. 楊祥發院士傑出農業科學年輕學者獎 (2014)

12. 國立成功大學101學年度教學傑出教師 (2013)

13. 農業生物技術產業化發展方案計畫登峰獎暨典範案例 (2013)

14. 台灣綜合大學系統年輕學者創新研究佳作 (2012)

15. 國科會101年度優秀年輕學者四年期研究計畫獎勵 (2012)

16. 教育部傑出通識課程 (2003-2005)

研究歷程

本人自2000年第一年開始攻讀碩士學位到2007年初在國立台灣大學完成博士學位；在2007年至日本東京海洋科技大學開啟蝦類免疫學研究領域。在2008年時，開始任教於國立成功大學，建立了[轉譯水產生物學實驗室](TLAB)。蝦類水產養殖是東亞最重要經濟活動之一，但卻面臨疾病導致大量死亡的威脅，正是促使本人研究蝦類[宿主-病原體-疾病]互動機制的最大動機。

在蝦類疾病致病機轉研究，本人逐步整合蝦類病原體學、蝦類整體基因體學、轉錄體學、蛋白質體學、代謝體、生物資訊學，導入生醫系統生物學研究策略於蝦類疾病探討，從多體學(Multi-omics)全面觀搜尋致病關鍵點，應用於建立抗病蝦篩選策略時的候選生物標記(biomarker)。

利用多體學，確定蝦類病毒WSSV於蝦細胞所驅動之有利於蝦隻病毒複製的特殊代謝轉變

蝦白點症是由蝦白點症病毒(WSSV)所造成之疾病，已威脅世界養蝦產業長達20餘年。王老師及其團隊利用前瞻水生動物研究策略，領先全球蝦類研究團隊建立蝦白點症病毒於蝦細胞所誘導之特殊代謝路徑與相關調控機制。為了瞭解造成蝦白點症(WSD)之病毒性病原體WSSV在感染過程中所依賴的宿主細胞代謝路徑，本團隊利用多組學(multiomics)於蝦體中建立病毒所驅動的代謝變化，並以活體實驗進行其重要性的驗證。本此研究策略下，發現WSSV是第一個被國際接受可驅動如脊椎動物癌症細胞特殊代謝反應(瓦氏效應)之無脊椎動物病毒。此理論填補過往對於無脊椎動物感染病原體後之代謝反應的空缺，更拓展現知代謝反應的範疇。本人及其團隊隨後又應用此策略，成功的鑑定出其他有助WSSV病毒複製的代謝路徑變化，包括Glutamine metabolism、脂質代謝(lipid metabolism)。近年來團隊再次突破，使用stable isotopic tracking確認在WSSV誘發少見的reductive glutamine metabolsim，後續也持續使用此平台探索致病機轉，逐步鑑定與測試促進此些效應的宿主因子以及可能病毒因子。因長期貢獻於WSSV研究，受國際病毒分類委員會(ICTV)的邀請，以通訊作者身分帶領四國學者共同撰寫最新一期的The 10th ICTV Report on Virus Taxonomy中，WSSV所隸屬之Nimaviridae專章。

利用多體學建構蝦類細菌性疾病AHPND與養殖環境之互動關係

2015年時，由團隊發現AHPND致病株(Vibrio parahaemolyticus; VP)所有之獨特質體—pVA1所表現的PirA B是造成肝胰腺病變主因。其後本團隊持續探討致病機轉，發現蝦胃組織是此菌菌落形成與增殖處，以上資訊與延伸專利皆提升AHPND檢測技術，如引子對設計與適當檢測組織。本團隊使用微生物菌相體學，長期觀測AHPND爆發池的蝦胃及水體菌相動態變化，從大數據中篩選候選預警菌種及可能可抵抗AHPND的候選益生菌。本團隊因此系列研究應英國學者邀請，與英美兩國共同提出病原體學(Pathobiomics)新概念。利用多體學研究能量，團隊確認蝦胃細胞會因驅動Rho pathway而促進細菌及毒素轉移到病灶，膽鹽可促進致病菌致病力，此些研究讓蝦飼料廠重新考量飼料添加膽鹽的必要性。我們在完全使用我們所得的多體學資訊，提出第一個整合型AHPND致病機制，獲得國際的肯定。

根據2021年中的資訊，本人在SCOPUS資料庫中共計有76篇文章(包括研討會摘要)，總引用次數超過2,862次(h-index: 29)。根據SciVal Metrics，2016~2021年的科學表現，46.9%為國際合著；在InCitesTM Journal Citation Reports®中，被引次數排名前10%之論文百分比為33.33% ( 依據所屬領域、發表年份和文獻類型引用等條件進行分析，研究者發表之文章屬於全球被引用率前10％的出版品)，整體學科正規化引文影響力(Category Normalized Citation Impact; CNCI)為1.83 (世界平均水準值為1)，專業CNCI指數如下-- Immunology: 3.75; Veterinary Sciences: 2.78; Zoology: 2.65。在SciVal Metrics，專業領域FWCI值(Field- Weighted Citation Impact)如下--Litopenaeus Vannamei; Probiotic Agent; Fingerlings (T.2271)]: 3.11; Inflammasomes; Pyroptosis; Pyrin Domain (T.2026): 2.27。從2008年至2022年共計有超過 50場國際會議英文演講，其中33次為邀請講者(Invited speaker)，目前也擔任許多國際職務，舉一例而言，其在2019年開始擔任Asian Fisheries Society (亞洲水產學會)副理事長，是近期最年輕的副理事長，並承辦20年來再次回到臺灣舉辦之13th Asian Fisheries and Aquaculture Forum (13th AFAF)。 

期刊論文 (*corresponding author)

1. Kumar R, Huang JY, Ng YS, Chen CY, Wang HC* (2021) The Regulation of Shrimp Metabolism by the White Spot Syndrome Virus (WSSV). Reviews in aquaculture. Accepted Ranking:0.018 (FISHERIES, 1/55 ), IF: 10.592. 

2. Huang YH, Kumar R, Liu CH, Lin SS, Wang HC* (2021) A novel C-type lectin LvCTL 4.2 has      antibacterial activity but facilitates WSSV infection in shrimp (L. vannamei) Dev. Comp.     Immunol.126:104239. Ranking: 0.034 (ZOOLOGY, 6/175), IF: 3.636. 

3. Luangtrakul W, Boonchuen P, Jaree P, Kumar R, Wang HC*, Somboonwiwat K*. (2021) Cytotoxicity of Vibrio parahaemolyticus AHPND toxin on shrimp hemocytes, a newly identified target tissue, involves binding of toxin to aminopeptidase N1 receptor. PLoS Pathogens. 17: e1009463. Ranking: 0.14 (MICROBIOLOGY, 20/137) IF: 6.823. 

4. Kumar R, Tung TC, Ng TH, Chang CC, Chen YL, Chen YM, Lin SS, Wang HC* (2021) Metabolic alterations in shrimp stomach during acute hepatopancreatic necrosis disease and effects of taurocholate on Vibrio parahaemolyticus. Front. Microbiol. 12:631468. Ranking: 0.20(MICROBIOLOGY, 28/137), IF: 5.640. 

5. Chen YL, Kumar R, Liu CH, Wang HC* (2021) In Litopenaeus vannamei, the cuticular chitin-binding proteins LvDD9A and LvDD9B retard AHPND pathogenesis but facilitate WSSV infection. Dev. Comp. Immunol. 120:103999. Ranking: 0.034 (ZOOLOGY, 6/175), IF: 3.636. 

6. Meng C, Liu LK, Li DL, Gao RL, Fan WW, Wang KJ, Wang HC, Liu HP* (2020) White spot syndrome virus benefits from endosomal trafficking, substantially facilitated by a valosin-containing protein, to escape autophagic elimination and propagate in crustacean Cherax quadricarinatus. J. Virol. 94:e01570-20. Ranking: 0.166 (VIROLOGY, 6/36), IF: 5.103 

7. Kao ZN, Liu CH, Liu WJ, Kumar R, Leu JH, Wang HC* (2020) Shrimp SIRT1 activates of the WSSV IE1 promoter independently of the NF-κB binding site. Fish Shellfish Immunol. 106:910-919.    Ranking: 0.034 (VETERINARY SCIENCES, 5/146), IF: 4.581. 

8. Morimotoa Ni, Okamuraa Y, Maekawab S, Wang HC, Aoki T, Konod T, Sakaid M, Hikima JI* (2020) ASC-deficiency impairs host defense against Aeromonas hydrophila infection in Japanese medaka, Oryzias latipes. Fish Shellfish Immunol. 105:427-437. Ranking: 0.034 (VETERINARY SCIENCES, 5/146), IF: 4.581. 

9. Wang HC*, Lin SJ, Mohapatra A, Kumar R, Wang HC* (2020) A review of the functional annotations of important genes in the AHPND-causing pVA1 plasmid. Microorganisms. 3;8(7):E996. Ranking: 0.379 (MICROBIOLOGY 52/137) IF: 4.128. 

10. Takahashi Y, Okamura Y, Morimoto N, Mihara K, Maekawa S, Wang HC, Aoki T, Kono T, Sakai M,      Hikima JI. (2020) Interleukin-17A/F1 from Japanese pufferfish (Takifugu rubripes) stimulates the  immune response in head kidney and intestinal cells. Fish Shellfish Immunol. 103:143-149.  Ranking: 0.034 (VETERINARY SCIENCES, 5/146), IF: 4.581. 

11. Chang YH, Kuo WC, Wang HC, Chen YM* (2020) Biocontrol of acute hepatopancreatic necrosis disease (AHPND) in shrimp using a microalgal-bacterial consortium. Aquaculture. 521: 734990.    Ranking:0.1 (MARINE & FRESHWATER BIOLOGY, 11/110), IF: 4.242 

12. Kumar R, Ng TH, Wang HC* (2020) Acute hepatopancreatic necrosis disease in penaeid shrimp. Reviews in aquaculture. 1–14. Ranking:0.018 (FISHERIES, 1/55 ), IF: 10.592. 

13. Apitanyasai K, Chang CC, Ng TH, Liu CH, Lo CF, Lin SS, Wang HC* (2020) Penaeus vannamei serine proteinase inhibitor 7 (LvSerpin7) acts as an immune brake by regulating the proPO system in AHPND-affected shrimp. Dev. Comp. Immunol. 106:103600. Ranking: 0.034 (ZOOLOGY, 6/175), IF: 3.636. 

14. Kumar R, Ng TH, Chang CC, Tung TC, Lin SS, Lo CF, Wang HC* (2019) Bile acid and bile acid transporters are involved in the pathogenesis of acute hepatopancreatic necrosis disease in white shrimp Litopenaeus vannamei. Cell Microbiol. e13127. Ranking: 0.437 (MICROBIOLOGY,   60/137), IF: 3.715. 

15. Apitanyasai K, Huang SW, Ng TH, He ST, Huang YH, Chiu SP, Tseng KC, Lin SS, Chang WC, Baldwin-Brown JG, Long AD, Lo CF, Yu HT, Wang HC* (2019) The gene structure and hypervariability of the complete Penaeus monodon Dscam gene. Scientific reports, 9:16595. Ranking:0.232 (MULTIDISCIPLINARY SCIENCES, 17/73 ), IF: 4.379. 

16. He ST, Lee DY, Tung CY, Li CY, Wang HC* (2019) Glutamine metabolism in both the oxidative and reductive directions is triggered in shrimp immune cells (hemocytes) at the WSSV genome replication stage to benefit virus replication. Front. Immunol. 10: 2102. Ranking: 0.148 (IMMUNOLOGY, 24/162), IF: 7.561. 

17. Bass D*. Stentiford G, Wang HC, Koskella, Tyler CR. (2019) The pathobiome in animal and plant diseases. Trends Ecol Evol. 34:996-1008. Ranking: 0.0060 (ECOLOGY, 1/166) IF: 17.712. 

18. Ng TH, Kumar R, Apitanyasai K, He ST, Chou SP, Wang HC* (2019) Selective expression of a “correct cloud” of Dscam in crayfish survivors after second exposure to the same pathogen. Fish Shellfish Immunol. 92:430-437. Ranking: 0.034 (VETERINARY SCIENCES, 5/146), IF: 4.581. 

19. Lin SJ, Chen YF, Hsu KC, Chen YL, Ko TP, Lo CF, Wang HC, Wang HC* (2019) Structural Insights to the Heterotetrameric Interaction between the Vibrio parahaemolyticus PirAvp and PirBvp Toxins and Activation of the Cry-Like Pore-Forming Domain. Toxins 11:233. Ranking: 0.222 (FOOD & TECHNOLOGY, 32/144) IF: 4.546. 

20. Wang HC*, Hirono I, Maningas MBB, Somboonwiwa K, Stentiford G, ICTV Report Consortium. ICTV Virus Taxonomy Profile: Nimaviridae. The ICTV 10th report -- Virus Taxonomy: The Classification and Nomenclature of Viruses. The ICTV website (www.ictv.global/report/nimaviridae). 

21. Wang HC*, Hirono I, Maningas MBB, Somboonwiwa K, Stentiford G, ICTV Report Consortium. (2019) ICTV Virus Taxonomy Profile: Nimaviridae. J Gen Virol. 100:1053–1054. Ranking:0.444 (VIROLOGY, 16/36) IF: 3.891. 

22. Tseng YT, Kumar R, Wang HC* (2019) LvRas and LvRap are both important for WSSV replication in Litopenaeus vannamei. Fish Shellfish Immunol. 88:150-160. Ranking: 0.034 (VETERINARY SCIENCES, 5/146), IF: 4.581. 

23. Ng TH, Lu CW, Lin SS, Chang CC, Tran LH, Chang WC, Lo CF, Wang HC* (2018) The Rho signaling pathway mediates the pathogenicity of AHPND-causing V. parahaemolyticus in shrimp. Cell Microbiol. 6:e12849. Ranking: 0.437 (MICROBIOLOGY,  60/137), IF: 3.715. 

24. Kumar R, Chang CC, Ng TH, Ding JY, Tseng TC, Lo CF, Wang HC* (2018) Draft genome sequence of Vibrio parahaemolyticus strain M1-1, which causes Acute Hepatopancreatic Necrosis Disease (AHPND) in shrimp in Vietnam. Genome Announc. e01468-17. RG Journal impact：0.78. 

25. Yeh YC, Kinoshita M, Ng TH, Chang YH, Maekawa S, Chiang YA, Aoki T, Wang HC*. (2017) Using CRISPR/Cas9-mediated gene editing to further explore growth and trade-off effects in myostatin-mutated F4 medaka (Oryzias latipes). Scientific reports, 7:11435. Ranking:0.232 (MULTIDISCIPLINARY SCIENCES, 17/73 ), IF: 4.379. 

26. Chen WY, Ng TZ, Wu JH*, Chen JW, Wang HC* (2017) Microbiome Dynamics in a Shrimp Grow-out Pond with Possible Outbreak of Acute Hepatopancreatic Necrosis Disease. Scientific reports, 7:9395. Ranking:0.232 (MULTIDISCIPLINARY SCIENCES, 17/73 ), IF: 4.379. 

27. Sun CK*, Tsai YC, Chen YJ, Liu TM, Chen HY, Wang HC, Lo CF. (2017) Resonant Dipolar Coupling of Microwaves with Confined Acoustic Vibrations in a Rod-shaped Virus. Scientific reports, 7: 4611. Ranking:0.232 (MULTIDISCIPLINARY SCIENCES, 17/73 ), IF: 4.379. 

28. Armitage AO*, Kurtz J*, Brites D, Dong Y, Pasquier LD, Wang HC. (2017) Dscam1 in Pancrustacean Immunity: Current Status and a Look to the Future. Front. Immunol. 8:662. Ranking: 0.148 (IMMUNOLOGY, 24/162), IF: 7.561 

29. Chang YH, Kumar R. Ng TZ, Wang HC* (2017) What vaccination studies tell us about immunological memory within the innate immune system of cultured shrimp and crayfish. Dev. Comp. Immunol. 68:12-20. Ranking: 0.034 (ZOOLOGY, 6/175), IF: 3.636. 

30. Maekawa S, Aoki T, Wang HC*. (2017) Constitutive overexpressed type I interferon induced downregulation of antiviral activity in medaka fish (Oryzias latipes). Dev. Comp. Immunol. 68:12-20. Ranking: 0.034 (ZOOLOGY, 6/175), IF: 3.636. 

31. Yeh YC, Wang TU, Chou HY, Lin HY, Chen TY, Aoki T, Wang HC*. (2016) A member of the immunoglobulin superfamily, orange-spotted grouper novel immune gene EcVig, is induced by immune stimulants and type I interferon. Fish Shellfish Immunol. 58:415-422. Ranking: 0.034 (VETERINARY SCIENCES, 5/146), IF: 4.581. 

32. Chen IT, Lee DY, Huang YT, Kou GH, Wang HC*, Chang GD*, Lo CF*. (2016) Six Hours after Infection, the Metabolic Changes Induced by WSSV Neutralize the Host's Oxidative Stress Defenses. Scientific reports. 6:27732. Ranking:0.232 (MULTIDISCIPLINARY SCIENCES, 17/73 ), IF: 4.379 

33. Li CY, Wang YJ, Huang SW, Cheng CS, Wang HC*. (2016) Replication of the shrimp virus WSSV depends on glutamate-driven anaplerosis. PLoS one. 11: e0146902.  Ranking: 0.356 (MULTIDISCIPLINARY SCIENCES, 26/73), IF: 3.240. 

34. Maekawa S, Chiang YA, Hikima J, Sakai M, Lo CF, Takeyama H, Wang HC*, Aoki T*. (2016) Expression and biological activity of two types of interferon genes in medaka (Oryzias latipes). Fish Shellfish Immunol. 48:20-29. Ranking: 0.034 (VETERINARY SCIENCES, 5/146), IF: 4.581. 

35. Chiang YA, Kinoshita M, Kaekawa S, Kulkarni A, Lo CF, Yoshiura Y, Wang HC*, Aoki T*.(2016) TALENs-mediated gene disruption of myostatin produces a larger phenotype of medaka with an apparently compromised immune system. Fish Shellfish Immunol. 48:212-220. Ranking: 0.034 (VETERINARY SCIENCES, 5/146), IF: 4.581. 

36. Lai HC, Ng TH, Ando M, Lee CT, Chen IT, Chang SH, Yeh MD, Chiang YA, Takeyama H, Hamaguchi H, Lo CF, Aoki T*, Wang HC*. (2015). Pathogenesis of acute hepatopancreatic necrosis disease (AHPND) in shrimp. Fish Shellfish Immunol. 47:1006-1014. Ranking: 0.034 (VETERINARY SCIENCES, 5/146), IF: 4.581. 

37. Liu BH, Lin YC, Ho CS, Yang CC, Chang YT, Chang JF, Li CY, Cheng CS, Lee YF, Hsu MH, Lin FC, Wang HC, Lo CF, Yang SY, Wang HC*. (2015) A novel detection platform for shrimp white spot syndrome virus using an ICP11-dependent immunomagnetic reduction (IMR) assay. PLoS one.  10(9): e0138207. Ranking: 0.356 (MULTIDISCIPLINARY SCIENCES, 26/73), IF: 3.240. 

38. Lee1 CT, Chen1 IT, Yang1 YT, Ko TP, Huang YT, Huang JY, Huang MF, Lin SJ, Chen CY, Lin SS, Lightner D, Wang HaC, Wang HJ, Wang HoC*, Hor LI*, Lo CF* (2015) The opportunistic marine pathogen Vibrio parahaemolyticus becomes virulent by acquiring a plasmid that expresses a deadly toxin. Proc. Natl. Acad. Sci. USA. 112: 10798-10803. Ranking: 0.109 (MULTIDISCIPLINARY SCIENCES, 8/73), IF: 11.205. 

39. Hsieh YC, Chen YM, Li CY, Chang YH, Liang SY, Lin SY, Lin CY, Chang SH, Wang YJ, Khoo KH, Aoki T, Wang HC*. (2015) To complete its replication cycle, a shrimp virus changes the population of long chain fatty acids during infection via the PI3K-Akt-mTOR-HIF1α pathway. Dev. Comp. Immunol. 53:85-95. Ranking: 0.034 (ZOOLOGY, 6/175), IF: 3.636.  

40. Ng TH, Chiang YA, Yeh YC, Wang HC* (2015) Reprint of Review of Dscam-mediated immunity in shrimp and other arthropods. Dev. Comp. Immunol. 48:306-314. Ranking: 0.034 (ZOOLOGY, 6/175), IF: 3.636. 

41. Ng TH, Wu MH, Chang SH, Aoki T, Wang HC* (2015) The DNA fibers of shrimp hemocyte extracellular traps are essential for the clearance of Escherichia coli. Dev. Comp. Immunol. 48:229-233. Ranking: 0.034 (ZOOLOGY, 6/175), IF: 3.636.  

42. Yang YT, Chen IT, Lee CD, Chen CY, Lin SS, Hor L, Tseng TC, Huang YT, Sritunyalucksana K, Thitamadee S, Wang HC, Lo CF* (2014) Draft genome sequences of four strains of Vibrio parahaemolyticus, three of which cause early mortality syndrome/acute hepatopancreatic necrosis disease in shrimp in China and Thailand. Genome Announc. 2:e00816-14. RG Journal impact：0.78. 

43. Ng TH, Hung HY, Chiang YA, Lin JH, Chen YN, Chuang YU, Wang HC* (2014) WSSV-induced crayfish Dscam shows durable immune behavior. Fish Shellfish Immunol. 40:78-90. Ranking: 0.034 (VETERINARY SCIENCES, 5/146), IF: 4.581. 

44. Su MA, Huang YT, Chen IT, Lee DY, Hsieh YC, Li CY, Ng TH, Liang SY, Lin SY, Huang SW, Chiang YA, Yu HT, Khoo KH, Chang GD, Lo CF, Wang HC* (2014) An invertebrate Warburg effect: a shrimp virus achieves successful replication by altering the host metabolome via the PI3K-Akt-mTOR pathway. PLOS Pathogens. 10:e1004196. Ranking: 0.194 (VIROLOGY, 7/36) IF: 6.823. 

45. Ng TH, Chiang YA, Yeh YC, Wang HC* (2014) Review of Dscam-mediated immunity in shrimp and other arthropods. Dev. Comp. Immunol. 46:129-138. Ranking: 0.034 (ZOOLOGY, 6/175), IF: 3.636. 

46. Tsai YL, Wang HC, Lo CF, Tang-Nelson K, Lightner D, Ou BR, Hour AL, Tsai CF, Yen CC, Chang HF, Teng PH, Lee PY*. (2014) Validation of a Commercial Insulated Isothermal PCR-based POCKIT Test for Rapid and Easy Detection of White Spot Syndrome Virus Infection in Litopenaeus vannamei. PLoS One. 9:e90545. Ranking: 0.356 (MULTIDISCIPLINARY SCIENCES, 26/73), IF: 3.240. 

47. Yeh YC, Hsu YJ, Chen YM, Lin HY, Yang HL, Chen TY, Wang HC* (2014) EcVig, a novel grouper immune-gene associated with antiviral activity against NNV infection. Dev. Comp. Immunol. 43:68-75. Ranking: 0.034 (ZOOLOGY, 6/175), IF: 3.636.. 

48. Kang ST, Wang HC, Yang YT, Kou GH, Lo CF* (2013) The DNA virus WSSV uses an internal ribosome entry site (IRES) for translation of the highly expressed non-structural protein ICP35. J. Virol. 87:13263-13278. Ranking: 0.25 (IROLOGY, 9/36), IF: 5.103. 

49. Hung HY, Ng TH, Lin JH, Chiang YA, Chuang YC, Wang HC* (2013)Properties of Litopenaeus vannamei Dscam (LvDscam) isoforms related to specific pathogen recognition. Fish Shellfish Immunol. 35:1272-1281. Ranking: 0.034 (VETERINARY SCIENCES, 5/146), IF: 4.581. 

50. Ng TH, Chang SH, Wu MH, Wang HC* (2013) Shrimp hemocytes release extracellular traps that kill bacteria. Dev. Comp. Immunol. 41:644-651. Ranking: 0.034 (ZOOLOGY, 6/175), IF: 3.636. 

51. Chiang YA, Hung HY, Lee CW, Huang YT, Wang HC* (2013) Shrimp Dscam and its cytoplasmic tail splicing activator Serine/arginine (SR)-rich protein B52 were both induced after white spot syndrome virus challenge. Fish Shellfish Immunol. 34:209-219. Ranking: 0.034 (VETERINARY SCIENCES, 5/146), IF: 4.581. 

52. Yeh YC, Lee CW, Pan YW, Hsu YJ, Hung HY, Chen YM, Lin HY, Chen TY, Yang HL, Wang HC* (2012) Identification and Characterization of DSCAM Isoforms Isolated From Orange-Spotted Grouper Epinephelus Coioides Dev. Comp. Immunol. 38:148-159. Ranking: 0.034 (ZOOLOGY, 6/175), IF: 3.636. 

53. Lin SJ, Hsia HL, Liu WJ, Huang JY, Liu KF, Chen WY, Yeh YC, Huang YT, Lo CF, Kou KH*, Wang HC* (2012) Spawning stress triggers WSSV replication in brooders via the activation of shrimp STAT. Dev. Comp. Immunol. 38:128-135. Ranking: 0.034 (ZOOLOGY, 6/175), IF: 3.636. 

54. Huang JY, Liu WJ, Wang HC, Lee DY, Leu JH, Wang HC, Tsai MH, Kang ST, Chen IT, Kou GH, Chang GD, Lo CF* (2012) Penaeus monodon thioredoxin restores the DNA binding activity of oxidized WSSV IE1. Antioxid Redox Signal. 17:914-926. Ranking: 0.103 (ENDOCRINOLOGY & METABOLISM, 15/145), IF: 8.401. 

55. Chang YS, Liu WJ, Chen TC, Chan TY, Liu KF, Chuang JC, Kou GH, Lo CF, Wang HC* (2012) Feeding hermit crabs to shrimp broodstock increases their risk of WSSV infection. Dis. Aquat. Org. 98:193-199. Ranking: 0.356 (VETERINARY SCIENCES, 52/146), IF: 1.802. 

56. Lee CW, Chen IT, Chou PH, Hung HY, Wang HC* (2012) Heterogeneous nuclear ribonucleoprotein hrp36 acts as an alternative splicing repressor in Litopenaeus vannamei Dscam. Dev. Comp. Immunol. 36:10-20. Ranking: 0.034 (ZOOLOGY, 6/175), IF: 3.636. 

57. Chen IT, Aoki T, Huang YT, Hirono I, Chen TC, Huang JY, Chang GD, Lo CF, Wang HC* (2011) White spot syndrome virus induces metabolic changes resembling the Warburg effect in shrimp hemocytes in the early stage of infection. J. Virol. 85:12919-12928. Ranking: 0.25 (IROLOGY, 9/36), IF: 5.103. 

58. Chen YM, Shih CH, Liu HC, Wu CL, Lin CC, Wang KC HC, Chen TY, Yang HL, Lin HY* (2011) An oral nervous necrosis virus vaccine using Vibrio anguillarum as an expression host provides early protection. Aquaculture. 321: 26-33.    Ranking:0.1 (MARINE & FRESHWATER BIOLOGY, 11/110), IF: 4.242 

59. Liu WJ, Chang YS, Huang WT, Chen IT, Wang KC HC, Kou GH, Lo CF*(2011) Penaeus monodon TATA box binding protein (PmTBP) interacts with the WSSV transactivator IE1 and promotes its transcriptional activity. J. Virol. 85:6535-6547. Ranking: 0.25 (IROLOGY, 9/36), IF: 5.103. 

60. Chou PH, Chang HS, Chen IT, Lee CW, Hung HY, Wang KC HC* (2011) Penaeus monodon Dscam (PmDscam) has a highly diverse cytoplasmic tail and is the first membrane-bound shrimp Dscam to be reported. Fish Shellfish Immunol. 30:1109-1123. Ranking: 0.034 (VETERINARY SCIENCES, 5/146), IF: 4.581. 

61. Lam FW, Wu SY, Lin SJ, Lin CC, Chen YM, Wang HC, Chen TY, Lin HT, Lin JH* (2011) The expression of two novel orange-spotted grouper (Epinephelus coioides) TNF genes in peripheral blood leukocytes, various organs, and fish larvae. Fish Shellfish Immunol. Ranking: 0.034 (VETERINARY SCIENCES, 5/146), IF: 4.581. 

62. Aoki T*, Wang HC, Unajak S, Santos MD, Kondo H, Hirono I (2010) Microarray analyses of shrimp immune responses. (Review paper) Mar. Biotechnol. 13:629-638. Ranking: 0.127 (MARINE & FRESHWATER BIOLOGY, 14/110), IF: 3.619 

63. Wang KC HC, Kondo H, Hirono I, Aoki T* (2010) The Marsupenaeus japonicus voltage-dependent anion channel (MjVDAC) protein is involved in white spot syndrome virus (WSSV) pathogenesis. Fish Shellfish Immunol. 29:94-103. Ranking: 0.034 (VETERINARY SCIENCES, 5/146), IF: 4.581. 

64. Wang KC HC, Tseng CW, Lin HY, Chen IT, Chen YH, Chen YM, Chen TY, Yang HL* (2010) RNAi knockdown of the Litopenaeus vannamei Toll gene (LvToll) significantly increases mortality and reduces bacterial clearance after challenge with Vibrio harveyi. Dev. Comp. Immunol. 34:49-58. Ranking: 0.034 (ZOOLOGY, 6/175), IF: 3.636. 

65. Chou PH, Chang HS, Chen IT, Lin HY, Chen YM, Yang HL, Wang KC HC* (2009) The putative invertebrate adaptive immune protein Litopenaeus vannamei Dscam (LvDscam) is the first reported Dscam to lack a transmembrane domain and cytoplasmic tail. Dev. Comp. Immunol. 33:1258-1267. Ranking: 0.034 (ZOOLOGY, 6/175), IF: 3.636. 

66. Kang ST, Leu JH, Wang HC, Chen LL, Kou GH, Lo CF* (2009) Polycistronic mRNAs and internal ribosome entry site elements (IRES) are widely used by white spot syndrome virus (WSSV) structural protein genes. Virology. 387:353-363. Ranking: 0.52 (VIROLOGY, 19/36), IF: 3.616. 

67. Wang HC, Wang HC, Ko TP, Lee YM, Leu JH, Ho CH, Hwang WP, Lo CF *, Wang Andrew H J*. (2008) White spot syndrome virus protein ICP11: A histone-binding DNA mimic that disrupts nucleosome assembly. Proc. Natl. Acad. Sci. USA. 105:20758–20763 (Co-first author) Ranking: 0.109 (MULTIDISCIPLINARY SCIENCES, 8/73), IF: 11.205. 

68. Chen W Y, Ho KC, Leu JH, Liu KF, Wang HC, Kou GH*, Lo CF*. (2008) WSSV infection activates STAT in shrimp. Dev. Comp. Immunol. 32:1142-1150. Ranking: 0.034 (ZOOLOGY, 6/175), IF: 3.636.

INVITED SPEECHES

1.           Wang HC* (2022) A comprehensive and collaborative approach is critical to promote successful shrimp aquaculture. “The 2nd International Conference on Sustainable Aquaculture: Health and Disease Management (Aqua-Thailand)” 17-18 March, 2022. (Keynote Speaker)

2.           Wang HC* (2022) The regulation of shrimp metabolism by the white spot syndrome virus (WSSV). “Novel Trends in Metabolomics and Systems Biology”. 11 March, 2022 (Invited Speaker) (Oral in Chinese)

3.           Wang HC* (2021) Relationship between shrimp gut health, microbiota and AHPND. FHS-AFS Webinar #4 (Bacterial Diseases). Online. 8 Dec 2021. (Invited Speaker)

4.           Wang HC* (2021) Healthy gut, healthy shrimp: Role of gut health and microbiome in shrimp aquaculture. “Aqu@Event by Adisseo: The New Blue is Green.” Online. 23. Nov 2021. (Invited Speaker) 

5.           Wang HC*. (2021). Healthy gut, healthy shrimp “The Control of Aquatic Animal Diseases” Online. 10 Sep, 2021. (Oral presentation) (Invited Speaker)

6.           Wang HC*. (2021). Interplay of Shrimp Gut Health in Disease “CPF-Adisseo seminar” Online. 16 Sep, 2021. (Oral presentation) (Invited Speaker)

7.           Wang HC*, Huang JY, Ding JY, Lo CF. (2019) Moving shrimp research from benchtop to pondside: generating new knowledge and using it to breed disease-resistant shrimp. The Fifth FRDC Australasian Scientific Conference on Aquatic Animal Health & Biosecurity. Cairns, Australia. July 8-12, 2019. (Oral presentation) (Invited Speaker)

8.           Wang HC* (2018) A system approach sheds new light on the pathogenesis of shrimp diseases WSD and AHPND. “2nd International and 9th Annual Convention of The Philippine Society For Cell Biology”. Oct 22-23, 2018 (Oral in English) (Invited Speaker)

9.           Wang HC* (2018) Pathogen-host-environment interplay: the case of AHPND/EMS in shrimp. 2018 Post-TARS. Chiang Mai, Thailand. 18 August, 2018. (Oral in English) (Invited Speaker)

10.        Wang HC* (2018). A shrimp virus, WSSV, changes the balance of host metabolism during infection to complete its replication. 2018 Taiwan-France (MOST- BFT ORCHID) Exchange Visits and Seminar. Changhua, Taiwan June 25- June 26, 2018. (Oral in English) (Invited Speaker)

11.        Wang HC* (2017) Dynamics of the Shrimp Stomach Bacterial Microbiome in an AHPND-affected Pond. " PHC-ORCHID Workshop". Keelung, Taiwan 24-28 Oct, 2017. (Oral in English) (Invited Speaker)

12.        Wang HC*(2017) Establishing the biosecurity system for shrimp aquaculture industry. Asian pacific aquaculture 2017. Kuala Lumpur, Malaysia. July 24-27, 2017. (Oral in English) (Invited Speaker)

13.        Wang HC*, Huang JY, Ding JY, Lo CF. (2019) Moving shrimp research from benchtop to pondside: generating new knowledge and using it to breed disease-resistant shrimp. The Fifth FRDC Australasian Scientific Conference on Aquatic Animal Health & Biosecurity. Cairns, Australia. July 8-12, 2019. (Oral presentation) (Invited Speaker)

14.        Wang HC* (2018) A system approach sheds new light on the pathogenesis of shrimp diseases WSD and AHPND. “2nd International and 9th Annual Convention of The Philippine Society For Cell Biology”. Oct 22-23, 2018 (Oral in English) (Invited Speaker)

15.        Wang HC* (2018) Pathogen-host-environment interplay: the case of AHPND/EMS in shrimp. 2018 Post-TARS. Chiang Mai, Thailand. 18 August, 2018. (Oral in English) (Invited Speaker)

16.        Wang HC* (2018). A shrimp virus, WSSV, changes the balance of host metabolism during infection to complete its replication. 2018 Taiwan-France (MOST- BFT ORCHID) Exchange Visits and Seminar. Changhua, Taiwan June 25- June 26, 2018. (Oral in English) (Invited Speaker)

17.        Wang HC* (2017) Dynamics of the Shrimp Stomach Bacterial Microbiome in an AHPND-affected Pond. " PHC-ORCHID Workshop". Keelung, Taiwan 24-28 Oct, 2017. (Oral in English) (Invited Speaker)

18.        Wang HC*(2017) Establishing the biosecurity system for shrimp aquaculture industry. Asian pacific aquaculture 2017. Kuala Lumpur, Malaysia. July 24-27, 2017. (Oral in English) (Invited Speaker)

19.        Wang HC* (2014) The applications of systems translational aquabiology for the screen of shrimp disease-resistance biomarkers. “Collaborative Platform for Sustainable Aquaculture – Southeast Asia International Joint-Research and Training Program”. Keelung, Taiwan, Nov. 4-5. (Oral in English) (Invited Speaker)

20.        Wang HC* (2014) Does specific acquired immunity exist in shrimp? – Moving Dscam research from benchtop to pondside. “The Aquaculture Round Table Series 2014”. Phuket, Thailand, August 20- 21. (Oral in English) (Invited Speaker)

21.        Wang HC* (2014) Insights into Dscam-mediated immunity in shrimp. “7th AOHUPO Congress and 9th International Symposium of the Protein Society of Thailand (7th AOHUPO/9th PST)”. Bangkok, Thailand, August 6 –8. (Oral in English) (Invited Speaker)

22.        Wang HC* (2013) From benchtop to pondside – moving basic shrimp Dscam research into industrial practices. Asia Pacific Aquaculture 2013. Ho Chi Minh City, Vietnam . Dec 10-13. (Oral in English) (Invited Speaker)

23.        Wang HC* (2012) WSSV Pathogenesis and Shrimp Innate Immunity with Specificity. The JSPS-NRCT Asian Core Program. Tokyo, Japan, Dec 7 (Oral in English) (Invited Speaker)

24.        Wang HC* (2012) WSSV pathogenesis and shrimp innate immunity with specificity. Meeting in Center of Excellence for Shrimp Molecular Biology and Biotechnology. Bangkok, Thailand, June 25-27. (Oral in English) (Invited Speaker)

25.        Wang KC HC* (2012) Shrimp immunity and WSSV pathogenesis. “2012 Taiwan – Japan Symposium on Emerging Trends in Aquatic Animal Immunity and Aquaculture Biotechnology”. Tainan, Taiwan, Feb 21 – Feb 22. (Oral in English) (Invited Speaker)

26.        Wang KC HC* (2011) Using systems biology approaches to understand shrimp cellular responses during viral infection. “Taiwan-UK collaborative Forum-System Biology Symposium” National Taiwan University. Taipei, Taiwan, Nov 28 - Nov29. (Oral in English) (Invited Speaker)

27.        Wang KC HC* (2011) White spot syndrome virus induces a Warburg-like effect in shrimp hemocytes in the early stage of infection. “8th Syndrome on Disease in Asian Aquaculture” Animal and Fisheries Sciences University. Mangalore, India, Nov 21- Nov 25. (Oral in English) (Invited Speaker)

28.        Wang KC HC*, Chou PH, Chang HS, Chen IT (2010) Alternative adaptive immunity in shrimp and its applications for the control of shrimp infectious diseases “International Forum for Adaptability Science II: Technologies for a Sustainable Society”. Sendai, Nov 30 – Dec 03. (Oral in English) (Invited Speaker)

29.        Wang KC HC*, Chen IT,  Chou PH, Aoki T, Lo CF (2010) Virus – host interaction: the pathogenesis of white spot syndrome virus infection and the alternative adaptive immunity in shrimp. Second International Symposium on “Aquatic Animal Defense Mechanisms against Invading Pathogens”. Jeju National University, Jeju, Korea. June 25. (Oral in English) (Invited Speaker)

30.        Wang KC HC* (2010) Alternative adaptive immunity in shrimp. STINT WORKSHOP. Uppsala University, Uppsala, Sweden. March 15-16. (Oral in English) (Invited Speaker)

31.        Wang HC*, Chen IT, Lo CF, Aoki T. (2009) Hexokinase involved in WSSV pathogenesis. Third Annual Meeting of the Thailand-Taiwan Shrimp Research Group. Taipei, Taiwan. Dec. 15. (Oral in English) (Invited Speaker)

32.        Wang HC*, Kondo H, Hirono I, Aoki T, Lo CF. (2008) Transcriptomic Analysis of Kuruma Shrimp Lymphoid Organ and White Spot Syndrome Virus (WSSV) Following WSSV Infection. 2008 Women in Marine Science & Biotechnology Academic Conference and Career Development. Keelung, Taiwan. Oct 27-28. (Oral in English) (Invited Speaker)

33.        Wang HC*, Kondo H, Hirono I, Aoki T. (2008) Functional characterization of a hexokinase from kuruma shrimp (Marsupenaeus japonicus). The 5th International Symposium of the Japanese Society for Fish Pathology. Tokyo, Japan. Oct 18-19. (Oral in English) (Invited Speaker)