Edith Traviers activates Centurion by calling Seneca Roberts and ordering him to collect his team and report to Martin Manor. Seneca leaves his home in the western suburbs of Chicago and heads to St. Charles, Illinois to pick up his executive office, Ward. What he finds in St. Charles is nothing short of the end of the world.

Meanwhile, in New York City, Edith recieves word from Desmond Martin himself that the Big Apple is about to locked down by the military and quarantined. She has 45 minuts to retrieve the HQ computer core and escape the city by any means possible. It's the only way to help find a cure and reverse the effects of Elixr.

And in Sault Ste. Marie, Michigan, a young paralegal named Jillian Downer flees the little border town as word spreads that all border crossings are to be locked down and quarantined until further notice. She escapes--barely--but with no where to go, finds herself on the road to Beacon Point, and she's bringing a reason to be afraid.