At lower doses, dopamine targets dopaminergic receptors, producing renal and mesenteric vasodilation
At higher doses, dopamine stimulates beta-receptors producing cardiac stimulation and renal vasodilation
At even higher doses, dopamine stimulates alpha-adrenergic receptors, acting primarily as a vasopressor
Stimulates V1 and V2 receptors, causing vasoconstriction and renal water retention
Increases SVR and can cause vasoconstriction, which may increase preload.
Can also increase heart rate.
Concentration: 400 mg/ 250 mL D5W (pre-mixed) **
800 mg/ 250 mL D5W (Central Line)
Starting Dose Range: 2 - 5 mcg/kg/min
Titration Dose Increment: 5 - 10 mcg/kg/min
Rate of Titration: 10 - 30 minutes
Maximum Dose: 20 mcg/kg/min
Maximum Peripheral Dose: 10 mcg/kg/min
Central/ Peripheral: central line preferred
** may be administered peripherally if only ONE vasopressor and if infusion < 12 hours
Note:
Doses up to 50 mcg/kg/min can be used, but is not common
Dopaminergic dose: 0.5 - 3 mcg/kg/min
Inotropic dose: 3- 10 mcg/kg/min
Vasopressor dose: 10 - 20 mcg/kg/min