Week 6: Biomarker Discovery

Background

• DNA sequencing technologies

• Types of genomic variations

Today's paper

pdf

"Identification of novel mutations by exome sequencing in African American colorectal cancer patients", Ashktorab et al Cancer, 121(1):34-42, 2014

Background

• Single cell analyses

• Phylogenetics

Today's paper

Requirements for course projects

pdf

Single-cell genetic analysis reveals insights into clonal development of prostate cancers and indicates loss of PTEN as a marker of poor prognosis, Heselmeyer-Haddad et al Am J Pathol. 2014 Oct;184(10):2671-86