Week 13: Advanced Topics

Lecture 25: CRISPR guide design

Topics (No videos. Lecture will be given live)

• Background

  • CRISPR/Cas prokaryotic adaptive immune system

  • Genome editing via CRISPR/CAS9

• Today's paper

Slides

• pdf

Required Reading

• DeepCRISPR: optimized CRISPR guide RNA design by deep learning, Chuai, et al Genome Biol. 2018 Jun 26;19(1):80. doi: 10.1186/s13059-018-1459-4

Thanksgiving (No lecture)