Week 3: Phenotyping

Lecture 5: Asthma Phenotyping

Topics/Videos

• Background

  • Clinical Phenotypes

  • Clinical Phenotype discovery via cluster analysis

• Today's paper

Slides

• pdf

Required Reading

• “Unsupervised phenotyping of Severe Asthma Research Program participants using expanded lung data.” J Allergy Clin Immunol. 133(5):1280-8

Optional Reading

• "Asthma phenotypes: the evolution from clinical to molecular approaches." Wenzel, Nat Med. 2012;18(5):716-25.

Lecture 6: Comorbidity Phenotyping

Topics/Videos

• Background

  • Electronic Health Records

  • Comorbidities

  • The Diagnostic and Statistical Manual of Mental Disorders (DSM)

• Today's paper

Slides

• pdf

Required Reading

• Comorbidity Clusters in Autism Spectrum Disorders: An Electronic Health Record Time-Series Analysis. Doshi-Velez et al Pediatrics. 2014, 133(1):e54-63