Week 1: Introduction & Background topics

Title Sequence (just for fun)

Motivation for this course

Mini lecture. (If you can follow this, then you should do fine in this course)

Course mechanics and requirements

pdf

"Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications" Sorlie, et al Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10869-74

"Molecular Portraits of human breast tumors" Perou, et al Nature 406, 747-752, 2000

"Gene expression profiling predicts clinical outcome of breast cancer" van't Veer, et al Nature. 2002 Jan 31;415(6871):530-6

"Gene expression profiling in breast cancer: classification, prognostication, and prediction" Reis-Filho and Pusztai,

How your surgeon could soon be replaced by a robot

Medicine & Disease

Personalized & Precision medicine

pdf

"P4 Medicine: Personalized, Predictive, Preventive, Participatory A Change of View that Changes Everything", Hood and Galas, CCC. 2008

Disease

Medicine

"The Role of Systems Biology in Predictive Health and Personalized Medicine", Voight and Brigham Open Pathology, 2008, 2, 68-70