Week 5: Biomarker Discovery

Background

• Biomarkers & Biomarker Discovery

• Feature Selection

Today's Paper

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Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles, Subramanian et al PNAS, 2005, 102 (43) 15545-15550

Background

• Odds ratios

• Survival Analysis

• Histology

• Cancer Staging

• Tissue microarrays

Today's paper

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A Molecular Signature Predictive of Indolent Prostate Cancer, Irshad et al Sci Transl Med. 2013; 5(202) doi: 10.1126/scitranslmed.3006408