Week 11: Modeling Interventions

Lecture 21: PK/PD modeling

Topics/Videos

• Background

  • Pharmacology & PK/PD modeling

• Today's paper

Slides

• pdf

Required Reading

• A population pharmacokinetic/pharmacodynamic model of thrombocytopenia characterizing the effect of trastuzumab emtansine (T-DM1) on platelet counts in patients with HER2-positive metastatic breast cancer. Bender, et al Cancer Chemother Pharmacol (2012) 70:591–601

Optional Reading

• Pharmacokinetic/Pharmacodynamic Modeling for Drug Development in Oncology, Garralda et al, DOI: 10.1200/EDBK_180460 American Society of Clinical Oncology Educational Book 37, 2018, pp. 210-215

Lecture 22: Designing controllers for implantable medical devices

Topics/Videos

• Background

  • Medical devices

  • PID controllers for closed-loop systems

• Today's paper

Slides

• pdf

Required Reading

• Synthesis of insulin pump controllers from safety specifications using Bayesian model validation, Jha, et al Int J Bioinform Res Appl. 2012;8(3-4):263-85.