Week 12: Modeling Interventions

Background

• Therapeutic proteins

• Immune system’s response to therapeutic proteins

Today's papers

pdf

Optimization algorithms for functional deimmunization of therapeutic proteins, Parker et al BMC Bioinformatics 2010 11:180 DOI: 10.1186/1471-2105-11-180

Mapping the Pareto Optimal Design Space for a Functionally Deimmunized Biotherapeutic Candidate, PLoS Comput Biol. 2015;11(1):e1003988. doi: 10.1371/journal.pcbi.1003988. eCollection 2015

Background

• Kalman Filters

• Gaussian Processes

Today's paper

pdf

•Inequality Constrained Kalman Filtering for the Localization and Registration of a Surgical Robot, Tully, et al IROS 2011

Using Bayesian Optimization to Guide Probing of a Flexible Environment for Simultaneous Registration and Stiffness Mapping, Ayvali et al ICRA 2016