Publications and Patents

I. Full Length Research Articles

  1. Baskaran, P, K Covington, J Bennis, A Mohandass, T E Lehmann and B Thyagarajan. Binding Efficacy and Thermogenic Efficiency of Pungent and Nonpungent Analogs of Capsaicin. Molecules 2018, 23 (12), 3199.
  2. Krishnan, V, Baskaran, P and B Thyagarajan. Troglitazone activates TRPV1 and causes deacetylation of PPAR gamma in 3T3-L1 cells. Biochimica et Biophysica Acta - Molecular Basis of Disease, Nov 2018. Accepted.
  3. Agarwal, S, J Fox, B Thyagarajan and JH Fox. Brain mitochondrial iron accumulates in Huntington's disease, mediates mitochodnrial dysfunction and can be remlved pharmacologically. Free Radic Biol Med 2018 May 20; 120:317-329.
  4. Baskaran, P and B Thyagarajan. Measurement of Basal and Forskolin-Stimulated Lipolysis in Inguinal Adipose Fat Pads. J. Vis. Exp. 2017 Jul 21; 125
  5. Thyagarajan, B, JG Potian, JJ McArdle and P Baskaran. Perturbation to Cholesterol at the Neuromuscular Junction Confers Botulinum Neurotoxin A Sensitivity to Neonatal Mice. Toxicol. Sci. June 22, 2017 Doi:10.1093/toxsci/kfx127.
  6. Baskaran, M, P Baskaran, A Navamoney and B Thyagarajan. Preparation and Evaluation of PLGA-Coated Capsaicin Magnetic Nanoparticles. Pharm Res. 2017 Jun; 34(6):1255-1263.
  7. Baskaran, P, V Krishnan, K Fettel, G Pang, Z Zhu, J Ren and B Thyagarajan. TRPV1 activation counters diet-induced obesity through sirtuin-1 activation and PRDM-16 deacetylation in brown adipose tissue. Int. J. Obes. Feb. 2017 p 1-11.
  8. Baskaran, P, V Krishnan, J Ren and B Thyagarajan. Capsaicin induces browning of white adipose tissue and counters obesity by activating TRPV1 channel-dependent mechanisms. Brit. J.Pharmacol. May 2016 DOI: 10.1111/bph.13514
  9. Asuthkar S, Demirkhanyan L, Sun X, Elustondo P, KrishnanV, Baskaran P, Velpula KK, Thyagarajan B, Pavlov E, ZakharianE. The TRPM8 Protein is a Testosterone Receptor. Part II: Functional Evidence for an Ionotropic Effect of Testosterone on TRPM8.J Biol Chem. 2014 Dec 5. pii: jbc.M114.610873.
  10. Asuthkar S, Elustondo PA, Demirkhanyan L, SunX, Baskaran P, Velpula KK, Thyagarajan B, Pavlov E, ZakharianE. The TRPM8 Protein is a Testosterone Receptor. Part I: Biochemical Evidence for Direct TRPM8-Testosterone Interactions. J Biol Chem. 2014 Dec 5. pii: jbc.M114.610824.
  11. Thyagarajan, B, JG Potian, P Baskaran andJJ McArdle. Capsaicin modulates acetylcholine release at myoneuroal junction. Eur. J. Pharmacol. 2014Dec 5;744:211-9. doi: 10.1016/j.ejphar.2014.09.044. Epub 2014 Oct 23.
  12. Padmamalini Baskaran and Baskaran Thyagarajan. Acute and chronic effects of botulinum neurotoxin A in mammalian neuromuscular junction. Muscle and Nerve. 2013 Nov 12. PMID: 24162247
  13. Baskaran, P, TE Lehmann, E Topchiy, NThirunavukkarasu, S Deshpande, BR Singh and B Thyagarajan. Effects of EnzymaticallyInactive Recombinant Botulinum Neurotoxin Type A at the Mouse NeuromuscularJunctions. Toxicon 2013 Jun 25. pii: S0041-0101(13) 00228-6. PMID:23810945
  14. Garcia CC, JG Potian, K Högnason, B Thyagarajan, L. G. Sultatos, VH Routh, and JJ McArdle. Acetylcholinesterase downregulation contributes to neuromuscular junction dysfunction in experimental type I diabetic neuropathy. Am. J. Physiol. 2012. PMID: 22739110. PMID: 21051321
  15. Ho, M, LHChang, M Pires-Alves, B Thyagarajan, JE Bloom, Z Gu, KK Aberle, SATeymorian, Y Bannai, JJ McArdle and BA Wilson. RecombinantBotulinum Neurotoxin A Heavy Chain-based Delivery Vehicles for Neuronal CellTargeting. Protein Eng Des Sel. 2011 Mar;24(3):247-53. PMID:21051321
  16. Potian JG, Vishwendra Patel, JJ McArdle and B Thyagarajan. The inveterate botulinum neurotoxin A ushers in exoendocytic crypts. The Botulinum J. 2010. 1(4). 418-430.
  17. Potian, JG, B Thyagarajan, K Hognason, F Lebeda, JJ Schmidt and JJ McArdle. Investigation of “CRATKML” derived peptides against botulinum neurotoxin A poisoning in vivo and in vitro. The Botulinum J. 2010. 1(4). 407-41
  18. Thyagarajan,B, JG Potian, CC Garcia, KHögnason, K Čapková, ST Moe, AR Jacobson, KD Janda& JJ McArdle. Effects ofhydroxamate metalloendoprotease inhibitors on botulinum neurotoxin A poisonedmouse neuromuscular junctions. Neuropharmacology. 2010. March 10. PMID:20211192
  19. Thyagarajan, B, N Krivitskaya, K Högnason, JGPotian, CC Garcia and JJ McArdle. Capsaicin protects functions of mouseneuromuscular junctions from the paralytic effects of botulinum neurotoxin A.J. Pharmacol. Exp. Ther. 2009; Nov; 331(2):361-71. PMID: 19654265.
  20. Patel, RJ, PD Patel, MM Patel, NJ Patel and B Thyagarajan. Mechanisms of potentiation of Angiotensin II-induced contractile response of isolated rat aorta by hydrogen peroxide and tert-butyryl hydroperoxide. Ind. J. Pharmacol. 2009; 41(3): 140-143. PMID: 20442823
  21. Zakharian, E, B Thyagarajan, RJ French, E Pavlov and T Rohacs. Inorganic polyphosphate modulates TRPM8 channels. PLoS ONE. 2009;4(4):e5404
  22. Thyagarajan, B, B Benn, S Christakos and T Rohacs. Phospholipase C mediated regulation of TRPV6 channels: implications in active intestinal Ca2+ transport. Mol Pharmacol. 2009. 75(3):608-16. PMID: 18528787.
  23. Hydrolysis of phosphatidylinositol 4,5-bisphosphate mediates calcium-induced inactivation of TRPV6 channels. Thyagarajan, B, V Lukacs and T Rohacs. J. Biol Chem. 2008. 283(22):14980-7
  24. Lukacs, V, Thyagarajan, B, A Balla, T Balla and T Rohacs. TRPV1 – Regulation b phosphoinositides. The Journal of Neuroscience, June 27, 2007 26 (26): 7070-7080 (First two authors contributed equally). PMID: 17596456
  25. Varnai, P, B Thyagarajan, T Rohacs and T Balla. Rapidly inducible changes in phosphatidyl inositol 4,5-bisphosphate levels to study multiple regulatory functions of the lipid in intact living cells. J Cell Biol. 2006 Nov 6;175(3):377-82. PMID: 17088424.
  26. Baskaran, T, R Malli, K Schmidt, WF Graier and K Groschner. Nitric oxide inhibits capacitative Ca2+ entry by suppression of mitochondrial Ca2+ handling. Br. J. Pharmacol. 2002.137(6):821-30. PMID:12411413
  27. Thyagarajan, B, M Poteser, C Romanin, H Kahr, MX Zhu and K Groschner. Expression of Trp3 determines sensitivity of capacitative Ca2+ entry to nitric oxide and mitochondrial Ca2+ handling. J. Biol. Chem. 2001. 276 (51). 48149-48158. PMID: 11600493
  28. Lintshinger, B, MB Geldsetzer, T Baskaran, WF Graier, C Romanin, MX Zhu and K Groschner. Coassembly of Trp 1 and Trp 3 proteins generates diacylglycerol- and Ca2+-sensitive cation channels. J. Biol. Chem. 2000 Sep 8; 275 (36). 27799-27805. PMID 18002720
  29. Dhanaraju, MD, KS Kumaran, T Baskaran and MS Moorthy. Enhancement of bioavailability of griseofulvin by its complexation with beta-Cyclodextrin. Drug Dev. Ind. Pharm. 1998. 24(6). 583-587

II. Peer-reviewed Review Articles

1. Thyagarajan, B. and Foster, MT. Beiging of white adipose tissue as a therapeutic strategy for weight loss in humans. Horm. Mol. Biol. Clin. Investig. 2017. Jun 23;31(2).

2. Baskaran, P, VKrishnan and B Thyagarajan. Implications of Obesity on Neuromuscular Functions - The known and unknown. BAOJ Obe Weigt Manage 2015, 1:1 1:003

3. B Thyagarajan and SS Deshpande. Cotrimoxazole and Neonatal Kernicterus: A Review. Drug Chem Toxicol. 2013 Oct 7. PMID: 24099411

4. Allman E, B Thyagarajan B and KW Nehrke. The Inositol 1,4,5-Trisphosphate Receptor in C. elegans. WIREs Membrane Transport and Signaling. 2012

5. Rohacs, T, B Thyagarajan and V Lukacs. Phospholipase C mediated modulation of TRPV1 channels. Mol Neurobiol. 2008 Apr-Jun;37(2-3):153-63. PMID: 19073818

6. Meru, AV, S Mittra, B Thyagarajan and A Chugh. Intermittent claudication: An overview. Atherosclerosis 2006 Aug;187(2):221-37. PMID:16386260

III. Peer-reviewed Research Articles on Social and Administrative Pharmacy

1. Singh, R, L Staubach, J Frantz and B Thyagarajan. Understanding Food Choice, Medication Use and Health From Lean and Non Lean Resident Perspectives in a Rural State. BAOJ Pharm. Sci. 2017, 3: 2 3: 034.


1. Thyagarajan, B and P Baskaran. Nanoparticle Delivery System for Targeted Anti-Obesity treatment (#9, 782, 481 B2) October 2017

2. Thyagarajan, B and P Baskaran. Nanoparticle delivery system for targeted anti-obesity treatment (# 9,320,749) April 2016

3. Thyagarajan, B and P Baskaran. Capsaicin upregulation of lipolytic proteins for treatment of nonalcoholic Fatty liver disease (#Provisional patent application serial number 62/235,829)

4. Thyagarajan, B and P Baskaran. TRPV1 Knock-In Method and TRPV1 Mice for Adipose Tissue Modulation (#US Provisional Patent Serial Number 62/351,131)

5. Thyagarajan, B and P Baskaran. Novel Target Site-Specific Pain Therapy with Botulinum Magnetic Aggregates (#Provision application no.62/689.107)

6. Thyagarajan, B and McArdle, JJ. Methods for Attenuating the Effects of Botulinum Toxin (#20100303932)

V. Book chapters

1. Springer's Handbook of Toxinology: Biological Toxins and Bioterrorism. Chapter on Botulinum Neurotoxin Antidotes (2015)

2. Intechopen's Capsaicin and its Human Therapeutic Development: Chapter on Capsaicin and metabolic diseases: A mini review on preclinical mechanisms and clinical efficacy (2018)

New mouse strains development:

  • TRPV1 - TRPA1 double knockout -