1. Lipid Metabolism, Cardiovascular Diseases, and Cancer Research:
My studies have been pivotal in understanding lipid metabolism and its implications in both cardiovascular diseases and cancer therapy. One of my most impactful areas of research involves the role of lipid pathways in selective cancer chemotherapy. My pioneering work in nano-encapsulation of lipid metabolism inhibitors has provided a promising direction for targeted cancer treatment, minimizing the side effects of traditional chemotherapeutic agents while enhancing their efficacy. Beyond oncology, my research in clinical chemistry has contributed to diagnostic advancements, particularly in lipidomics, inflammation markers, and metabolic disorders. My work on platelet indices in lung cancer patients and ischemia-modified albumin levels has provided valuable insights into biomarker-based disease monitoring and early cancer detection. Additionally, my investigations into atherogenic lipids, ADAMTS gene expression, and endothelial dysfunction contribute to the understanding of metabolic disorders and their clinical implications. My studies on genetic polymorphisms in warfarin metabolism and thrombotic risk markers have practical applications in personalized medicine and anticoagulant therapy.
2. Hematology, Coagulation, and Clinical Pathology:
I have extensively studied coagulation disorders, hematologic malignancies, and inflammatory biomarkers. My research on vitamin K-dependent coagulation factors, thrombosis risk assessment, and cytokine profiles in inflammatory conditions has advanced knowledge in clinical hematology and immunology. My work in pre-eclampsia, neonatal sepsis, and maternal-fetal biomarkers has also contributed to advancements in perinatal medicine and early disease detection. My research on serum cytokine levels in inflammatory disorders and genetic markers in disease susceptibility further highlights my expertise in translational medicine.
3. Toxicology and Environmental Medicine:
My research extends to toxicology, where I have examined the impact of environmental toxins such as carbon monoxide and heavy metals on oxidative stress mechanisms and cellular damage. My studies have led to a better understanding of the biochemical pathways involved in toxicity and have influenced therapeutic interventions for toxic exposures.
4. Clinical Chemistry and Diagnostic Innovations:
My work has contributed to biomarker discovery, laboratory medicine, and precision diagnostics. My studies on ischemia-modified albumin, vitamin B12 reference intervals, and novel markers for oxidative stress have helped refine clinical laboratory testing methods and improve patient monitoring and disease prognosis.
5. Textbook Authorship and Educational Resources:
I have authored multiple textbooks that serve as foundational resources in biochemistry, clinical chemistry, and laboratory medicine. My textbooks, including Basic & Clinical Biochemistry and Medical Biochemistry, provide comprehensive insights into biochemical principles, diagnostic techniques, and clinical applications. These resources are widely used in medical, pharmacy, and physician assistant programs.
My ongoing research aims to integrate lipidomics, mass spectrometry, and biomarker discovery into early cancer detection and personalized medicine. My extensive collaborations across multiple institutions reflect the interdisciplinary nature of my work, bridging fundamental biochemical research with clinical applications.