Tissue Engineering & Regenerative Medicine
Major challenges in the field:
- To chemically modify materials for better adhesion, where spatial control over cell adhesion can be achieved.
- To develop new approaches to deliver multiple active bio molecules and modulate release profiles from a single delivery system.
- To develop a new material that can assembled into higher order and respond to stimuli.
We are working on developing silk based scaffolds for regiospecific stem cell differentiation. We are also interested in understanding material properties that can effect stem cell differentiation, cellular attachment and cell growth.
Controlling the Cell Adhesion Property of Silk Films by Graft Polymerization
ACS Applied Materials & Interfaces 2014, 6 (7), 5005.
Modifications of silk film for dual delivery
Biomedical Materials, 2017, 12 (4), 045017
Spatially controlled functional group grafting of silk films to induce osteogenic and chondreogenic differentiation of human mesenchymal stem cells
Materials Science and Engineering: C, 2018,19, 796–805
Self-Patterning Silk Films for Cellular Coculture
ACS Appl. Bio Mater., 2018, 1 (5), pp 1355–1361