Media&Talks

Media

A new scaffold made from silk protein fibroin and silver nanoparticles has been found to have antimicrobial properties and may have application as a biomaterial for implants

New material from silk protein and silver nanoparticles may make implants safe

OUR RECENT WORK AT IIT DELHI TO DEVELOP A NOVEL PLATFORM TO TEST DRUG SENSITIVITY IN BACTERIA WAS PUBLISHED BY FEW NEWS PORTALS.

Our recent work in collaboration with Dr. Shalini Gupta at Chemical Engineering Department at IIT Delhi gathered attention from the media and some of it is exemplified in the following paragraphs that are excerpts from some of the news portals.

The work was published in Scientific Reports.

"Dual functionality nanobioconjugates targeting intracellular bacteria in cancer cells with enhanced antimicrobial activity."

1. SCIENCE MONITOR AT RAJYA SABHA TV PUBLISHED ON SEP 2, 2017.

2. The Indian Express: August 5th 2017

"An all-women team of researchers from the Indian Institute of Technology (IIT) Delhi has developed a new drug delivery platform, using nanoparticles, which they say will more effectively target bacterial infections, improving chances of recovery from cancer-related secondary infections."

3. BIOTECH TIMES: July 27th 2017

Women Team of Indian Scientists develop novel antibiotic delivery system

4. India Live Today: August 15th 2017

"All women IIT Delhi researcher team develop new drug delivery platform using nanoparticles that can boost the efficacy of antibiotics at cellular level"

5. Times of India : August 5th 2017

"IIT WOMEN FIND WAY TO POWER UP ANTIBIOTICS"

6. The Hindu: August 5th 2017

A new antibiotic drug-delivery system that improves the efficacy of drugs thereby reducing the dosage used for treating bacterial infections has been tested in a lab by researchers at the Indian Institute of Technology (IIT) Delhi. A peptide, which has not been approved for clinical use, bound to gold nanoparticles was able to kill E. coli and Salmonella typhi more efficiently at lower dosages.

7. India Saga: July 27th 2017

"Researchers at the Indian Institute of Technology Delhi (IIT-D) have used nanoconjugates - nanoparticle bound with molecules to render them with added biological features - in this context. The new study demonstrates that the nanoparticle-bound antibacterial agent, a short molecule called sushi-peptide, was more efficient than anti-bacterial agent alone."

8. BiovoiceNews: July 28th 2017

"Researchers at the Indian Institute of Technology Delhi (IIT-D) have used nanoconjugates - nanoparticle bound with molecules to render them with added biological features useful for treatment of cancer"

Apart from scientific publication and citations our work has also gathered attention from the media and some of it is exemplified in the following paragraphs that are excerpts from some of the news portals.

1. “Label-Free Biosensing with Hydrogel Microlenses”, Angew. Chem. Intl. Ed., 2006, 45, 1446-1449.

“Scientists at Georgia Tech have created technology capable of detecting trace amounts of biological or chemical agents in a matter of seconds, much faster than traditional methods, which can take hours or up to a day. The system uses reusable hydrogel microlenses so small that millions of them can fit on a one-inch-square plate. It could greatly enhance the ability of authorities responding to a biological or chemical weapons attack as well as increase the speed of medical testing.”

- http://www.biologynews.net

Some other places where the work was highlighted:

• http://homelandsecuritynewswire.com

• www.physorg.com

• www.bioresearchonline.com

2. “Effect of Nanoparticle Conjugation on siRNA gene silencing” J. Am. Chem. Soc., 2010, 132, 8241–8243

“The authors conducted a well-designed study to evaluate small interfering (si)RNA conjugation strategies to quantum dots. They examined the effect of labile vs. non-labile, short vs. long and passenger vs. guide strand linkage to the nanoparticle on gene silencing in vitro. The outcome clarifies a general approach that can be used by other laboratories -- be labile or be long, and it doesn't matter to which strand you attach the nanoparticle. This systematic study provides observations that should influence the approaches taken by other groups working in the siRNA delivery area.” - Selected by Faculty of 1000 as Recommended, Factor 6.0

3. “Now, investigators at the Massachusetts Institute of Technology (MIT) have developed a modular nanoparticle-based drug delivery system that maximizes the quantity of siRNA molecules that not only can enter cells but also can escape into the cytoplasm, where they can interfere with protein production.”- http://nano.cancer.gov

“Functional Delivery of siRNA in Mice Using Dendriworms” ACS Nano, 2009, 3, 2495-504.

Some other places where the work was highlighted:

• www.news-medical.net

• www.nanotech-now.com

• www.btsurvivor.com

www.physorg.com

4. Nanoparticles that Communicate In Vivo to Amplify Tumour Targeting” Nature Materials, 2011, 10, 545–552

· http://www.genengnews.com/gen-news-highlights/scientists-develop-communicating-nanoparticles-that-boost-targeted-drug-delivery-to-tumors/81245326/

· http://blogs.scientificamerican.com/guest-blog/2011/07/08/learning-from-insect-swarms-smart-cancer-targeting/

· http://medgadget.com/2011/06/nanoparticles-use-bodys-own-communication-pathway-to-deliver-anti-cancer-drug.html

· http://www.science20.com/curious_cub/nanoteam_takes_tumors-80193

TALKS

1. Singh, N.; “Cubosomes as Drug Delivery Vehicles” Invited Speaker, NanoBio-2014, India. July 06, 2014.

2. Singh, N.; “Tuning Nanostructures for enhanced bio-functionality” Invited Speaker, 6th International Conference On Nano Science And Technology (ICONSAT), 2014, India, March 04, 2014.

3. Singh, N.; “Cubosomes for Theranostic Applications” Invited Speaker, Seminar Electron Microscopy Society, West Zone Chapter, India. 21 Februray, 2014.

4. Singh, N.; “Tuning Nanostructures for enhanced bio-functionality” Invited Speaker, International Conference on Chemical Biology-2014, India. Feb 06, 2014.

5. Singh, N.; “Cubosomes for Theranostic Applications” Invited Speaker, Dr. Reddy’s Research Lab, India. Feb 05, 2014.

6. Singh, N.; “Tuning Nanostructures for enhanced bio-functionality” Invited Speaker, Royal Society of Chemistry India Roadshow, NCL Pune, India. Feb 11, 2013.

7. Singh, N.; “Tuning Nanostructures for enhanced bio-functionality” Invited Speaker, Cell Mechanics Meeting, Raman Research Institute, Bangalore, India. Jan 31, 2012.

8. Singh, N.; “Soft Nanomaterials and Human Health” Invited Speaker, AICTE Sponsored SDP on Recent Advances in Nanoscience and Nanotechnology at UDCT Jalgaon, India. June 23, 2012

9. Singh, N.; “Nanopariticle based Technologies: Bridging the gap between cancer genomic discovery and in vivo target validation” Invited Panelist for discussions on “Personalized Cancer Treatment: Onco-markers, Oncogenomics and beyond” at Biocon Symposium on Integrative Research in Oncology, Biocon Research Centre, Bangalore, India, May 15, 2012.