Drug Delivery

Drug Delivery

The goal is to create nanostructures based on optimization of molecular and nanoscale interactions of the material with cells. We rely on studies elucidating which properties of a material crucially affect bioactivity at the molecular level. Structure-bioactivity relationships can be established by systematically synthesizing nanostructures with varied structural motifs and studying the effect of such variations on the mechanisms of their cellular internalization, their biological function, elimination process, and toxicity. In a typical study, we carry out the synthesis of the nanostructures followed by rigorous characterization of both its structural and functional properties.

We are trying to develop more efficacious delivery system for RNA interference and small molecule delivery. We are also interested in carrying out studies, which shed insight into the cellular fate of delivery vehicles. We believe these studies will provide us with design rules for developing nanomaterials with enhanced bioactivities.

Some of the recent work pulished

Influence of Cubosome Surface Architecture on Its Cellular Uptake Mechanism

Langmuir 2017, 33 (14), 3509-3516

Mitigating the Cytotoxicity of Graphene Quantum Dots and EnhancingTheir Applications in Bioimaging and Drug Delivery

ACS Macro Letters 2014, 3 (10), 1064

Enhancing cubosome functionality by coating with a single layer of poly-ε-lysine

ACS Applied Materials & Interfaces 2014, 6 (19)

Dual functionality nanobioconjugates targeting intracellular bacteria in cancer cells with enhanced antimicrobial activity

Scientific Reports 2017, 7 (1), 5792.

Core/shell nanoparticles as an efficient sustained-triggered drug delivery system.

ACS Omega, 2017, 2 (10), 6455

Enhancing Gene-Knockdown Efficiency of Poly(N-isopropylacrylamide) Nanogels.

ACS Omega. 2018, 3 (7), 8042

Probing the nanoparticle–AGO2 interaction for enhanced gene knockdown

Soft Matter, 2018, 14, 4169-4177