The goal is to create nanostructures based on optimization of molecular and nanoscale interactions of the material with cells. We rely on studies elucidating which properties of a material crucially affect bioactivity at the molecular level. Structure-bioactivity relationships can be established by systematically synthesizing nanostructures with varied structural motifs and studying the effect of such variations on the mechanisms of their cellular internalization, their biological function, elimination process, and toxicity. In a typical study, we carry out the synthesis of the nanostructures followed by rigorous characterization of both its structural and functional properties.
We are trying to develop more efficacious delivery system for RNA interference and small molecule delivery. We are also interested in carrying out studies, which shed insight into the cellular fate of delivery vehicles. We believe these studies will provide us with design rules for developing nanomaterials with enhanced bioactivities.
Some of the recent work pulished
Influence of Cubosome Surface Architecture on Its Cellular Uptake Mechanism
Langmuir 2017, 33 (14), 3509-3516
Mitigating the Cytotoxicity of Graphene Quantum Dots and EnhancingTheir Applications in Bioimaging and Drug Delivery
ACS Macro Letters 2014, 3 (10), 1064
Enhancing cubosome functionality by coating with a single layer of poly-ε-lysine
ACS Applied Materials & Interfaces 2014, 6 (19)
Dual functionality nanobioconjugates targeting intracellular bacteria in cancer cells with enhanced antimicrobial activity
Scientific Reports 2017, 7 (1), 5792.
Core/shell nanoparticles as an efficient sustained-triggered drug delivery system.
ACS Omega, 2017, 2 (10), 6455
Enhancing Gene-Knockdown Efficiency of Poly(N-isopropylacrylamide) Nanogels.
ACS Omega. 2018, 3 (7), 8042
Probing the nanoparticle–AGO2 interaction for enhanced gene knockdown
Soft Matter, 2018, 14, 4169-4177