The Department of Computational Biology and Bioinformatics has a modest library with a stock of close to 4363 books (as of June 2024) and continuing to grow.  In addition theses, dissertations, academic archives etc. originating from the Department are available. The department has funds to acquire books worth a few lakh rupees every year and students and researchers are encouraged to select and suggest books to enrich the library collection. The library is enriched by exclusive gift collections from DCB members (Dr. AchuthSankar S. Nair, Dr. Pawan K. Dhar, Dr. Oommen V. Oommen, Dr. P.R Sudhakaran, Dr. Umesh P and Dr. Vinod Chandra). DCB library is using an open source library management software Koha. It is a full featured Integrated Library System (ILS). The book operations of the library are fully computerized and the on-line public access catalog (OPAC) is accessible from anywhere from the world. Kerala University has a union catalogue database also campus library union catalogue of all department libraries. The circulation process is done using Barcode technology. The department provides secured Property Lockers for keeping the personal belongings of the members. They can keep their valuables including laptop, handbags, books, etc. in the property locker .

The library is open on all working days from 9.30 am till 4.30 pm.