Yukon-Charley Rivers National Preserve can be accessed by air taxi from Fairbanks. A popular destination is the Coal Creek mining camp airstrip. Plan to spend at least an hour exploring the restored mining camp. Outfitters provide rafting trips down the Yukon and the Charley Rivers. The main Ranger Station and Headquarters for this unit is at Eagle Alaska which can be reached by car, bus or air taxi.
NPTC boundaries definition for Yukon-Charley Rivers National Preserve
"There are no visitor centers within the Preserve. Both the Fairbanks Headquarters and the Eagle Field Office are located outside the Preserve boundaries. You must fly-in, boat-in, or hike-in to the Preserve boundaries." - NPTC