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Our Bruker Bioscope Resolve is a powerful bio-AFM, featuring the highest resolution imaging and most accurate and complete cell mechanics capabilities. Fast scanning is available with the large piezo scanner range on this platform, making it ideal for examining large objects such as cells and tissues. The integration of an inverted Nikon TI2 fluorescence microscope enables more comprehensive sample characterisation by simultaneous AFM and optical imaging. The long range fully motorised stage can accommodate sample substrates with various sizes and ensures easy sample access and navigation. Samples can also be in situ heated up to 60 ºC, which is essential for applications on living systems.
Specifications:
Max. sample size: Glass coverslips up to 75x25mm, plastic and glass bottom Petri dishes with 35 to 60mm diameter.
Max. size of a single scan: 100μm x 100μm with 15μm Z range.
Working environment: Air and liquid. Software controlled heating stage up to ~60ºC.
In-situ optics: Inverted Nikon TI2 fluorescence microscope; a top view camera for optical brightfield observation of opaque samples.
Imaging modes: Contact Mode, Tapping Mode, ScanAsyst, PeakForce QNM, Force Spectroscopy and Force Volume, MIRO View (i.e. semi-auto correlation with optical images), FastScanBIO and FastTapping, NanoLighography, Nanomanipulation
Fields of applications:
High resolution imaging, mechanical tests (e.g. elastic properties, interaction forces, etc.) and nanomanipulation of biological samples under near physiological conditions (tissues, cells, viral particles, hydrogels applications, biomedical devices, and individual biomolecules), etc.
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