IID3

Summary

Determine the overall incidence of IID in the UK population.
Establish the incidence of IID presenting to primary care.
Clarify the proportion of IID that is UK-acquired.
Describe the pathogens causing IID in the UK, including levels of antimicrobial resistance (AMR).
Re-calibrate UK surveillance data for IID overall and by pathogen.
Determine the number of cases in the community, GP reported cases, hospitalisations, and deaths due to IID in the UK.
Compare results from the IID3 study with previous studies.

For more information please click HERE for the full summary.

Sponsor - Newcastle University

Recruitment End Date - April 2025

Type of Study - Recruitment

RSI Points - 400 (Cohort 1) 300 (Cohort 2)

Must be a member of the Oxford Royal College of General Practitioners (RCGP) Research and Surveillance Centre (RSC); sign a GP Site Agreement with the University of Oxford.
Must have someone at the practice to act as research lead, usually GCP trained, and attend training meetings with the Study Team. Cohort 1 (Household) - conduct database search for eligible patients (EMIS/SystmOne search file will be provided), recruitment of households, gathering consent and sending link to baseline questionnaire (online), monitoring of IID status reporting, (if symptomatic) requesting test and giving kit to patient, sending link to symptom questionnaire, coding of study participation and results.
Cohort 2 (GP Presentation) – recruitment of symptomatic patients, requesting test and giving kit to patient, gathering consent and sending link to symptom questionnaire, coding of study participation and results. The practice may be asked to run a validation search to identify the number of patients with eligible symptoms at the practice.

Inclusion

Persons with loose stools or clinically significant vomiting lasting less than two weeks, in the absence of a known non-infectious cause, preceded by a symptom-free period of three weeks. Vomiting is considered clinically significant if it occurs more than once in a 24-hour period and if it incapacitates the case or is accompanied by other symptoms such as cramps or fever

Exclusion

Patients with terminal illness.
Patients with severe mental incapacity.
Patients who do not speak English and for whom a suitable interpreter is not available.
Surgical obstruction.
Patients with non-infectious causes of diarrhoea. This means: - Crohn’s disease - Ulcerative Colitis - Cystic Fibrosis - Coeliac disease

***To express an interest for the IID3 study please use the form provided and a member of the team will be in touch***