Announcement has been made by Dr. Myrna Weissman of New York and New Haven and Dr. Sherman Weissman of New Haven of the engagement of their daughter Susan Weissman to Douglas Reifler, the son of Carolyn Bailey of Westlake Village, Calif., and Ronald Reifler of Claremont, Calif. A June wedding is planned.

Miss Weissman, who graduated from Brown University, is project manager of a medical software program at Scientific American Inc. in New York, publisher of Scientific American magazine and Scientific American Medicine. Her mother is a professor of psychiatry and epidemiology at the Yale University School of Medicine, where her father is a professor of human genetics, molecular biology and internal medicine.

The prospective bridegroom, a medical student at the University of California at San Diego, graduated from Harvard College and was formerly an associate ediitor of Scientific American Medicine. His father is president of Reifler Associates, a management consulting concern in Claremont. His mother is a systems analyst.

Sambra Lynn Bayer and Dr. Sherman Morton Weissman were married yesterday in Dwight Chapel at Yale University. Rabbi Mark Panoff officiated.

Mrs. Weissman, the assistant director of community relations at Gracie Square Hospital in Manhattan and a psychotherapist in private practice, is a daughter of Mr. and Mrs. Harvey Bayer of Youngwood, Pa. She is a graduate of the University of Pittsburgh and received master's degrees from Columbia University's Teachers College and School of Social Work. She attended the Postgraduate Center for Mental Health in Manhattan. Her father is a retired pharmacist.

Dr. Weissman, a professor at the Yale University School of Medicine, is a graduate of Northwestern University, the University of Chicago and the Harvard University School of Medicine. He is a son of the late Dr. and Mrs. David Weissman of Chicago. His father was a general practitioner. His previous marriage ended in divorce.