Shimadzu LCMS-2020 Single Quad

The Shimadzu LCMS-2020 Single Quadrupole LC/MS with UV-Vis detection is a versatile instrument capable of analyzing a broad range of samples, especially those requiring compound separation and identification. 

Suitable Sample Types:

• Thermally unstable, large, polar, ionic, or non-volatile compounds: LC/MS is well-suited for these types of molecules, where Gas Chromatography/Mass Spectrometry (GC/MS) may not be appropriate.

• Pharmaceutical samples: Detection of trace impurities in pharmaceuticals is a key application.

• Environmental pollutants: Analysis of contaminants in various environmental matrices.

• Food and beverage samples: Used for quality control and analysis of food additives, residual veterinary drugs, and supplements.

• Chemicals: Identification and analysis of compounds in chemical manufacturing and synthesis.

• Biological samples: Analysis of drugs, vitamins, and minerals in blood, plasma, serum, and urine; also applicable to metabolomics, proteomics, and genomics studies. 

Capabilities:

• Liquid Chromatography (LC): Provides efficient separation of complex mixtures before entering the mass spectrometer.

• Single Quadrupole Mass Spectrometry (MS): Offers mass confirmation and identification of separated compounds.

• UV-Vis Detection: The LC system includes a dual wavelength UV-Vis detector for additional detection capabilities.

• Dual Ionization Source (DUIS): Allows simultaneous use of Electrospray Ionization (ESI) for high polarity compounds and Atmospheric Pressure Chemical Ionization (APCI) for low-to-medium polarity compounds, extending the range of detectable analytes.

• High-Speed Analysis: Features include ultrafast polarity switching (15 msec) and fast scanning speeds (15,000 u/sec), which are beneficial for analyzing narrow peaks from UHPLC systems.

• High Sensitivity: The LCMS-2020 is designed for high sensitivity and accurate detection of trace impurities.

• UHPLC Compatibility: Optimized for integration with Shimadzu's Prominence UFLC/UFLCXR and Nexera UHPLC systems, enhancing separation performance and productivity. 

In essence, the Shimadzu LCMS-2020, with its combined LC/MS and UV-Vis capabilities, is a powerful tool for analyzing a wide range of organic compounds in various applications, particularly where sensitive and rapid detection of impurities or unknown compounds is crucial.