研究業績


A.原著論文・総説

*論文名をクリックするとPubmedまたは論文掲載ページに飛びます。

<2023年>

Kanoh T, Lu J, Mizoguchi T, Itoh M. The E3 ubiquitin ligase MIB1 suppresses breast cancer cell migration through regulating CTNND1 protein level. Biochem Biophys Res Commun. 2023 Jul 30;667:73-80. doi: 10.1016/j.bbrc.2023.05.034. Epub 2023 May 11. PMID: 37209565.

Mizoguchi T, Okita M, Minami Y, Fukunaga M, Maki A, Itoh M. Age-dependent dysfunction of the cerebrovascular system in the zebrafish telencephalon. Exp Gerontol. 2023 Jul;178:112206. doi: 10.1016/j.exger.2023.112206. Epub 2023 May 17. PMID: 37196825.

Mizoguchi T, Mikami S, Yatou M, Kondo Y, Omaru S, Kuwabara S, Okura W, Noda S, Tenno T, Hiroaki H, Itoh M. Small-Molecule-Mediated Suppression of BMP Signaling by Selective Inhibition of BMP1-Dependent Chordin Cleavage. Int J Mol Sci. 2023 Feb 21;24(5):4313. doi: 10.3390/ijms24054313. PMID: 36901744; PMCID: PMC10001940.

Lyu S, Terao N, Nakashima H, Itoh M, Tonoki A. Neuropeptide diuretic hormone 31 mediates memory and sleep via distinct neural pathways in Drosophila. Neurosci Res. 2023 Jul;192:11-25. doi: 10.1016/j.neures.2023.02.003. Epub 2023 Feb 11. PMID: 36780946.

Hou X, Hayashi R, Itoh M, Tonoki A. Small-molecule screening in aged Drosophila identifies mGluR as a regulator of age-related sleep impairment. Sleep. 2023 May 10;46(5):zsad018. doi: 10.1093/sleep/zsad018. PMID: 36721967.


<2022年>

Tonoki A, Nagai S, Yu Z, Yue T, Lyu S, Hou X, Onuki K, Yabana K, Takahashi H, Itoh M. Nitric oxide-soluble guanylyl cyclase pathway as a contributor to age-related memory impairment in Drosophila. Aging Cell. 2022 Sep;21(9):e13691. doi: 10.1111/acel.13691. Epub 2022 Aug 13. PMID: 35963012; PMCID: PMC9470885.

Mizoguchi T, Handa H, Omaru S, Itoh M. Artificial Notch Signaling Activation Method Using Immobilized Ligand Beads. Methods Mol Biol. 2022;2472:57-66. doi: 10.1007/978-1-0716-2201-8_6. PMID: 35674892.

Handa H, Idesako N, Itoh M. Immobilized DLL4-induced Notch signaling is mediated by dynamics of the actin cytoskeleton. Biochem Biophys Res Commun. 2022 Apr 30;602:179-185. doi: 10.1016/j.bbrc.2022.02.084. Epub 2022 Feb 23. PMID: 35287005.

Imai M, Mizoguchi T, Wang M, Li Y, #Hasegawa Y, Tonoki A, *Itoh M. The guppy (Poecilia reticulata) is a useful model for analyzing age-dependent changes in metabolism, motor function, and gene expression. Exp Gerontol. 2022 Apr;160:111708. doi: 10.1016/j.exger.2022.111708. Epub 2022 Jan 18. 


<2021年>

Chaichit S, Sato T, Yu H, Tanaka YK, Ogra Y, Mizoguchi T, *Itoh M. Evaluation of Dexamethasone-Induced Osteoporosis In Vivo Using Zebrafish Scales. Pharmaceuticals (Basel). 2021 Jun 3;14(6):536. doi: 10.3390/ph14060536. PMID: 34205111; PMCID: PMC8228068.


Yang P, Takahashi H, Murase M, *Itoh M. Zebrafish behavior feature recognition using three-dimensional tracking and machine learning. Sci Rep. 2021 Jun 29;11(1):13492. doi: 10.1038/s41598-021-92854-0. PMID: 34188116; PMCID: PMC8242018.


Suzuki S, Hiura S, Mashiko T, Matsumoto T, *Itoh M. Lunatic fringe promotes the aggregation of CADASIL NOTCH3 mutant proteins. Biochem Biophys Res Commun. 2021 Jun 11;557:302-308. doi: 10.1016/j.bbrc.2021.04.031. Epub 2021 Apr 21. PMID: 33894418.


Wang Z, Mizoguchi T, Kuribara T, Nakajima M, Iwata M, Sakamoto Y, Nakamura H, Murayama T, Nemoto T, *Itoh M. Py3-FITC: a new fluorescent probe for live cell imaging of collagen-rich tissues and ionocytes. Open Biol. 2021 Feb;11(2):200241. doi: 10.1098/rsob.200241. Epub 2021 Feb 10. PMID: 33561382; PMCID: PMC8061698.



<2020年>

*#Takahashi H., #Miyaki S., #Onouchi H., Motomura T., Idesako N., Takahashi A., Murase M., Fukuyoshi S., Endo T., Satou K., Naito S., and *Itoh M., Exhaustive identification of conserved upstream open reading frames with potential translational regulatory functions from animal genomes, Sci. Rep. 2020 Oct 1;10(1):16289. doi: 10.1038/s41598-020-73307-6.


Mizoguchi T, Fukada M, Iihama M, Song X, Fukagawa S, Kuwabara S, Omaru S, Higashijima SI, *Itoh M. Transient activation of the Notch-her15.1 axis plays an important role in the maturation of V2b interneurons. Development. 2020 Aug 27;147(16):dev191312. doi: 10.1242/dev.191312. PMID: 32855202.


*Tonoki A, Ogasawara M, Yu Z, Itoh M. Appetitive memory with survival benefit is robust across aging in Drosophila. J Neurosci. 2020 Mar 11;40(11):2296-2304. doi: 10.1523/JNEUROSCI.2045-19.2020. Epub 2020 Jan 28.



<2019年>

Yang P, Yamaki M, Kuwabara S, Kajiwara R, Itoh M. A newly developed feeder and oxygen measurement system reveals the effects of aging and obesity on the metabolic rate of zebrafish.  Exp Gerontol.. 2019 Nov;127:110720. doi: 10.1016/j.exger.2019.110720. Epub 2019


Lyu, S., Tonoki, A. (2019). Drosophila Behavior Genetics. In: Choe, J.C. (Ed.), Encyclopedia of Animal Behavior, (2nd ed.).. vol. 2, pp. 259-266. Elsevier, Academic Press.


バイオインフォマティクスによる配列データベース横断解析に基づく機能上流ORFの推定 髙橋 広夫,伊藤 素行, 尾之内 均 生物工学会誌.第97巻 第8号(2019),496-499 



<2018年>

Kuwabara S, Yamaki M, Yu H, Itoh M. Notch signaling regulates the expression of glycolysis-related genes in a context-dependent manner during embryonic development. Biochem Biophys Res Commun. 2018 Sep 5;503(2):803-808. 



<2017年>

Umehara K, Sun Y, Hiura S, Hamada K, Itoh M, Kitamura K, Oshima M, Iwama A, Saito K, Anzai N, Chiba K, Akita H, Furihata T. A New Conditionally Immortalized Human Fetal Brain Pericyte Cell Line: Establishment and Functional Characterization as a Promising Tool for Human Brain Pericyte Studies. Mol Neurobiol. 2017 Nov 11.


Mizoguchi T, Ikeda S, Watanabe S, Sugawara M, *Itoh M. Mib1 contributes to persistent directional cell migration by regulating the Ctnnd1-Rac1 pathway. Proc Natl Acad Sci U S A. 2017 Oct 31;114(44):E9280-E9289. 査読有


Yang P, Kajiwara R, Tonoki A, *Itoh M. Successive and discrete spaced conditioning in active avoidance learning in young and aged zebrafish. Neurosci Res. Available online 14 October 2017.


Yoneyama T, Arai MA, Akamine R, Koryudzu K, Tsuchiya A, Sadhu SK, Ahmed F, Itoh M, Okamoto R, Ishibashi M. Notch Inhibitors from Calotropis gigantea That Induce Neuronal Differentiation of Neural Stem Cells. J Nat Prod. 2017 Sep 22;80(9):2453-2461.


Tanabe K, Itoh M, Tonoki A. Age-Related Changes in Insulin-like Signaling Lead to Intermediate-Term Memory Impairment in Drosophila. Cell Rep. 2017 Feb 14;18(7):1598-1605.


Liu L, Wada H, Matsubara N, Hozumi K, *Itoh M. Identification of domains for efficient Notch signaling activity in immobilized Notch ligand proteins. J Cell Biochem. 2017 Apr;118(4):785-796. 



<2016年>

*Matsuda M, Rand K, Palardy G, Shimizu N, Ikeda H, Nogare DD, Itoh M, *Chitnis AB. Epb41l5 competes with Delta as a substrate for Mib1 to coordinate specification and differentiation of neurons. Development. 2016 Sep 1;143(17):3085-96.


*Kawakami K, Asakawa K, Hibi M, Itoh M, Muto A, Wada H. Gal4 Driver Transgenic Zebrafish: Powerful Tools to Study Developmental Biology, Organogenesis, and Neuroscience. Adv Genet. 2016;95:65-87.


Mizoguchi T, Kawakami K, *Itoh M. Zebrafish lines expressing UAS-driven red probes for monitoring cytoskeletal dynamics. Genesis. 2016 Sep;54(9):483-9. 


Okano M, Matsuo H, Nishimura Y, Hozumi K, Yoshioka S, Tonoki A, *Itoh M. Mib1 modulates dynamin 2 recruitment via Snx18 to promote Dll1 endocytosis for efficient Notch signaling.Genes Cells.2016 May;21(5):425-441. 



<2015年>

Mikami S, Nakaura M, Kawahara A, Mizoguchi T, *Itoh M. Mindbomb 2 isdispensable for embryonic development and Notch signaling in zebrafish. Biol Open. 2015, 4(11):1576-82.


Ohishi K, Toume K, Arai MA, Koyano T, Kowithayakorn T, Mizoguchi T, Itoh M, *Ishibashi M. 9-Hydroxycanthin-6-one, a β-Carboline Alkaloid from Eurycoma longifolia, Is the First Wnt Signal Inhibitor through Activation of Glycogen Synthase Kinase 3β without Depending on Casein Kinase 1α.  J Nat Prod. 2015, 78(5):1139-46. 


Tonoki A, Davis RL. Aging impairs protein-synthesis-dependent long-term memory in Drosophila. J Neurosci. 2015, 35(3):1173-80. 



<2011~2014年>

<2014年>

Okigawa S, Mizoguchi T, Okano M, Tanaka H, Isoda M, Jiang YJ, Suster M, Higashijima S, Kawakami K, Itoh M. Different combinations of Notch ligands and receptors regulate V2 interneuron progenitor proliferation and V2a/V2b cell fate determination. Dev Biol. 2014, 391:196-206.


Itoh M#, Nakaura M, Imanishi T, Obika S. Target Gene Knockdown by 2',4'-BNA/LNA Antisense Oligonucleotides in Zebrafish.  Nucleic Acid Ther. 2014, 3:186-91. 


Chihara T., Kitabayashi A., Morimoto M., Takeuchi K., Masuyama K., Tonoki A., Davis RL.,Wang JW., Miura M. Caspase inhibition of select olfactory neurons rejuvenates innate attraction behavior in aged Drosophila. Plos Genetics. 2014 Jun 26; 10(6)


<2013年>

Takeishi A,, Kuranaga E., Tonoki A., Misaki K., Yonemura S., Kanuka H,, Miura M.Homeostatic epithelial renewal in the gut is required for dampening a fatal systemic wound response in Drosophila. Cell Reports. 2013, 3(3): 919-30


<2012年>

Hozumi S, Hirabayashi R, Yoshizawa A, Ogata M, Ishitani T, Tsutsumi M, Kuroiwa A, Itoh M, Kikuchi Y. DEAD-box protein Ddx46 is required for the development of the digestive organs and brain in zebrafish. PLoS One. 2012;7(3):e33675.


Ota S, Ishitani S, Shimizu N, Matsumoto K, Itoh M, Ishitani T. NLK positively regulates Wnt/β-catenin signalling by phosphorylating LEF1 in neural progenitor cells.EMBO J. 2012, 31:1904-1.


Tonoki, A., Davis, RL., Aging impairs intermediate-term behavior memory by disrupting the dorsal paired medial neuron memory trace. Proc. Natl. Acad. Sci. USA. 2012, 109 (16), 6319-24.


<2011年>

Mizoguchi T, Togawa S, Kawakami K, Itoh M#. Neuron and sensory epithelial cell fate is sequentially determined by Notch signaling in zebrafish lateral line development. J Neurosci. 2011, 31:15522-15530


Yoshizawa A, Nakahara Y, Izawa T, Ishitani T, Tsutsumi M, Kuroiwa A, Itoh M, Kikuchi Y. Zebrafish DmrtA2 is required for neurogenesis in the posterior-dorsal telencephalon. Genes to Cells. 2011, 16:1097-109. 



<2001~2010年>

<2010年>

Yamamoto M, Morita R, Mizoguchi T, Matsuo H, Isoda M, Ishitani T, Chitnis AB, Matsumoto K, Crump JG, Hozumi K, Yonemura S, Kawakami K, Itoh M#. Mib-Jag1-Notch signalling regulates patterning and structural roles of the notochord by controlling cell-fate decisions. Development. 2010, 137:2527-37.


Sugiyama K, Nishide K, Matsuo H, Okigawa S, Okano M, Ishitani T, Matsumoto K, Itoh M#. Delta1 family members are involved in filopodial actin formation and neuronal cell migration independent of Notch signaling. Biochem Biophys Res Commun. 2010, 398:118-124.


Ishitani T#, Hirao T, Suzuki M, Isoda M, Ishitani S, Harigaya K, Kitagawa M, Matsumoto K, Itoh M#. Nemo-like kinase suppresses Notch signalling by interfering with formation of the Notch active transcriptional complex. Nat. Cell Biol. 2010, 12:278-285.


<2009年>

Ishitani T#, Ishitani S, Matsumoto K, Itoh M#. Nemo-like kinase is involved in NGF-induced neurite outgrowth via phosphorylating MAP1B and paxillin. J. Neurochem. 2009, 111:1104-1118.


<2007年>

Tsutsumi M, Itoh M#. Novel transcript nort is a downstream target gene of the Notch signaling pathway in zebrafish. Gene Expr Patterns. 2007, 7:227-32.


Kita, M., Roy, M.C., Siwu, E.R.O., Noma, I., Takiguchi, T., Itoh, M., Yamada, K., Koyama, T., Iwashita, T, and Uemura, D#. Durinskiol A: a long carbon-chain polyol compound from the symbiotic dinoflagellate Durinskia sp. Tetrahedron Lett. 2007, 48:3423–3427.


<2005年>

Ishitani T., Matsumoto K., Chitnis AB., Itoh M#.  Nrarp functions to modulate neural-crest-cell differentiation by regulating LEF1 protein stability. Nat. Cell Biol. 2005, 7:1106 – 1112.


<2004年>

Chitnis AB#., Itoh M. Exploring alternative models of rostral-caudal patterning in the zebrafish neurectoderm with computer simulations. Curr Opin Genet Dev. 2004, 14:415-21.


<2003年>

Itoh, M., Kim C-H., Palardy G., Oda T., Jiang Y-J., Maust D., Yeo S-Y., Lorick K., Wright G.J., Ariza-McNaughton L., Weissman A.M., Lewis J., Chandrasekharappa S.C. and Chitnis A.B#. Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta. Dev. Cell. 2003, 4:67-82.


Dorsky, R. I.*, Itoh,M.*, Moon R.T., and Chitnis AB#.  Two tcf3 genes cooperate to pattern the zebrafish brain by setting the baseline of a Wnt activity gradient in the neuroectoderm (*equally contributed). Develompment. 2003. 130:1937-47.


Itoh M.*, Tallafuß A., Chapouton P., Tannhäuser B., Kuwada J.Y., Chitnis A.B. and Bally-Cuif L#. Regional inhibition of neurogenesis by the zebrafish bHLH transcription factor Her5 shapes the midbrain-hindbrain neuronal differentiation pattern. (*equally contributed), Develompment. 2003. 130:1591-604.


Yamasaki S., Nishida K., Yoshida Y., Itoh M., Hibi M., Hirano T#. Gab1 is required for EGF receptor signaling and the transformation by activated ErbB2. Oncogene. 2003. 22:1546-56.


<2002年>

Itoh M., Kudoh T., Dedekian M., Kim CH., Chitnis A.B#. A role for iro1 and iro7 in the establishment of an anteroposterior compartment of the ectoderm adjacent to the midbrain-hindbrain boundary. Development. 2002. 129:2317-27.


Itoh, S., M. Itoh, K. Nishida, S. Yamasaki, Y. Yoshida, M. Narimatsu, S. J. Park, M. Hibi, K. Ishihara, and T. Hirano#. Adapter molecule Gab1 is specifically expressed in marginal zone B cells and negatively regulates TI-2 responses. J. Immunol. 2002 168:5110-5116.


<2001年>

Narimatsu M, Maeda H, Itoh S, Atsumi T, Ohtani T, Nishida K, Itoh M, Kamimura D, Park SJ, Mizuno K, Miyazaki J, Hibi M, Ishihara K, Nakajima K, Hirano T#. Tissue-specific autoregulation of the stat3 gene and its role in interleukin-6-induced survival signals in T cells. Mol. Cell. Biol. 2001 ;21:6615–6625.


Itoh M, Chitnis AB#. Expression of proneural and neurogenic genes in the zebrafish lateral line primordium correlates with selection of hair cell fate in neuromasts. Mech Dev. 2001. 102:263-6.


<2000年>

Kim C-H, Oda T, Itoh M, Jiang D, Artinger KB, Chandrasekharappa SC, Driever W, Chitnis A.B#.  Repressor activity of Headless/Tcf3 is essential for vertebrate head formation.  Nature. 2000. 407:913-6.


Itoh M, Yoshida Y, Nishida K, Narimatsu M, Hibi M, Hirano T#.  Role of Gab1 in heart, placenta, and skin development and growth factor- and cytokine-induced extracellular signal-regulated kinase mitogen-activated protein kinase activation. Mol Cell Biol. 2000. 10:3695-704.


Ohtani T, Ishihara K, Atsumi T, Nishida K, Kaneko Y, Miyata T, Itoh S, Narimatsu M, Maeda H, Fukada T, Itoh, M, Okano H, Hibi M, Hirano T#. Dissection of signaling cascades through gp130 in vivo: reciprocal roles for STAT3- and SHP2-mediated signals in immune responses. Immunity. 2000. 1:95-105.


Hashimoto H, Itoh M, Yamanaka Y, Yamashita S, Shimizu T, Solnica-Krezel L, Hibi M, Hirano T#. Zebrafish Dkk1 functions in forebrain specification and axial mesendoderm formation. Dev Biol. 2000. 1:138-52. 



<1994~2000年>

<2000年>

Kim C-H, Oda T, Itoh M, Jiang D, Artinger KB, Chandrasekharappa SC, Driever W, Chitnis A.B#.  Repressor activity of Headless/Tcf3 is essential for vertebrate head formation.  Nature. 2000. 407:913-6.


Itoh M, Yoshida Y, Nishida K, Narimatsu M, Hibi M, Hirano T#.  Role of Gab1 in heart, placenta, and skin development and growth factor- and cytokine-induced extracellular signal-regulated kinase mitogen-activated protein kinase activation. Mol Cell Biol. 2000. 10:3695-704.


Ohtani T, Ishihara K, Atsumi T, Nishida K, Kaneko Y, Miyata T, Itoh S, Narimatsu M, Maeda H, Fukada T, Itoh, M, Okano H, Hibi M, Hirano T#. Dissection of signaling cascades through gp130 in vivo: reciprocal roles for STAT3- and SHP2-mediated signals in immune responses. Immunity. 2000. 1:95-105.


Hashimoto H, Itoh M, Yamanaka Y, Yamashita S, Shimizu T, Solnica-Krezel L, Hibi M, Hirano T#. Zebrafish Dkk1 functions in forebrain specification and axial mesendoderm formation. Dev Biol. 2000. 1:138-52.


<1999年>

Nishida, K., Y. Yoshida, M. Itoh, T. Fukada, T. Ohtani, T. Shirogane, T. Atsumi, M. Takahashi-Tezuka, K. Ishihara, M.Hibi, and T. Hirano#. Gab-family adapter proteins act downstream of cytokine and growth factor receptors, and T and B cell antigen receptors. Blood. 1999. 93:1809.


<1998年>

Itoh, M., K. Ishihara, T. Hiroi, B. Ok Lee, H. Maeda, H. Iijima, M. Yanagita, H. Kiyono, and T. Hirano#. Deletion of BST-1(CD157) gene impaired systemic TI-2 antigen-induced IgG3 and mucosal TD antigen-elicited IgA responses. J. Immunol. 1998. 161: 3974-3983.


<1997年>

Ishihara, K., Okuyama, Y., Lee, B.OK, Itoh, M., Nishikawa, K., and Hirano, T#. Structure, expression, and function of BST-1: its identity with Mo5. in Leucocyte typing VI. 1086-1089, 1997.


Doi, T.#, T. Minami, M. Itoh, H. Aburatani, Y. Kawabe, T. Kodama, N. Kondo, Y. Satoh, T. Asayama, and T. Imanishi. An alternative form of nucleolysin binds to a T-cluster DNA in the silencer element of platelet factor 4 gene. Biochem Biophys Res Commun. 1997. 235:625-30.


<1996年>

Ishihara, K., Y. Kobune, Y. Okuyama, M. Itoh, B. O. Lee, O. Muraoka, and T. Hirano#. Stage-specific expression of mouse BST-1/BP-3 on the early B and T cell progenitors prior to gene rearrangement of antigen receptor. Int Immunol. 1996. 8:1395-404.


Muraoka, O., H. Tanaka, M. Itoh, K. Ishihara, and T. Hirano#. Genomic structure of human BST-1. Immunol Lett. 1996.54:1-4.


Lee, B. O., K. Ishihara, K. Denno, Y. Kobune, M. Itoh, O. Muraoka, T. Kaisho, T. Sasaki, T. Ochi, and T. Hirano#. Elevated levels of the soluble form of bone marrow stromal cell antigen 1 in the sera of patients with severe rheumatoid arthritis. Arthritis Rheum. 1996.39:629-3


Okuyama, Y., K. Ishihara, N. Kimura, Y. Hirata, K. Sato, M. Itoh, L. B. Ok, and T. Hirano#. Human BST-1 expressed on myeloid cells functions as a receptor molecule. Biochem Biophys Res Commun. 1996. 228:838-45.


Kajimoto, Y#., J.-I. Miyagawa, K. Ishihara, Y. Okuyama, Y. Fujitani, M. Itoh, H. Yoshida, T. Kaisho, T. Matsuoka, H. Watada, T. Hanafusa, Y. Yamasaki, T. Kamada, Y. Matsuzawa, and T. Hirano. Pancreatic islet cells express BST-1, a CD 38-like surface molecule having ADP-ribosyl cyclase activity. Biochem Biophys Res Commun. 1996. 219:941.


<1995年>

Ishikawa, J., T. Kaisho, H. Tomizawa, B. O. Lee, Y. Kobune, J. Inazawa, K. Oritani, M. Itoh, T. Ochi, K. Ishihara, and T. Hirano#. Molecular cloning and chromosomal mapping of a bone marrow stromal cell surface gene, BST2, that may be involved in pre-B-cell growth. Genomics. 1995. 26:527-34.


<1994年>

Itoh, M., K. Ishihara, H. Tomizawa, H. Tanaka, Y. Kobune, J. Ishikawa, T. Kaisho, and T. Hirano#.  Molecular cloning of murine BST-1 having homology with CD38 and Aplysia ADP-ribosyl cyclase. Biochem Biophys Res Commun. 1994.203:1309-17. 


B.参考論文(査読なし)邦文総説

Mizoguchi T, Itoh M.  Notch signal.

生体の科学, 2015, 66, 440-441.


伊藤素行  細胞運命決定に関わるNotchシグナルとその調節機構

生体の科学, Vol.61 No.6, p624-629, 2010


石谷 太、松本邦弘、伊藤素行 Nemo-like kinaseはNotch転写複合体の形成を阻害し,神経細胞形成を促進する

実験医学, 2010年6月号 Vol.28 No.9


伊藤素行 ユビキチン・プロテアソーム系によるデルタ・ノッチシグナルの調節

神経研究の進歩, Vol.40 No.1 p125-131, 2004 


C.その他メディア、新聞報道など

2003年に我々が発表したMind bombの論文がDevelopmental Cell 誌の10th Anniversaryとして、Linda Hickeによりピックアップされ、ビデオにて解説した(リンク参照)。August, 2011

 http://www.cell.com/developmental-cell/abstract/S1534-5807%2811%2900265-6


Cell signaling: NLK turns it down a Notch: The UCSD Signaling Gatewayにて細胞シグナル伝達分野の注目論文としてピックアップされた(リンク参照)。February 2010

http://www.signaling-gateway.org/update/updates/201002/su-1002-2.html


神経細胞の増殖の仕組み解明、読売新聞、平成22年2月1日


神経細胞形成 仕組み解明、中日新聞、平成22年2月1日


神経幹細胞から神経細胞 変化促進酵素を特定 日刊工業新聞、平成22年2月1日 脳内の酵素、神経分化促す、名古屋大、仕組み解明に光 共同通信、平成22年2月1日 


D.高校生へのサイエンス研修

平成23年5月23日 愛知県新城東高校 2年生24名

大学模擬授業:遺伝子変異による個体発生異常とゼブラフィッシュ変異体の観察


平成22年8月2-6日 岡崎高校スーパーサイエンスハイスクール 2年生2名受け入れ

研究室体験研修:ゼブラフィッシュ胚のin situハイブリダイゼーション、インジェクション実験、Notchシグナルや神経発生の講義(Notchシグナルとneurogenin1は側線神経節の分化にかかわるか、Notchシグナルの神経分化における役割)など。