Experiences 

Current Positions:

2019~ , Chair Professor, National Chung Hsing University (NCHU).

2019~ , Chief Director, Biotechnology Center, NCHU.

2019~ , Director, Ph.D. Program in Microbial Genomics, NCHU.

2019~ , Director, Ph.D. Program in Tissue Engineering and Regenerative Medicine, NCHU.

2007~ , Professor, Institute of Biomedical Sciences, NCHU.

2007~ , Professor, Institute of Molecular Biology, NCHU.

2014~ , Chairman, Taiwan Genomics and Genetics Society.

Working Experiences:

2018~ , Lifetime Distinguished Professor, National Chung Hsing University.

2014~ , Honorary Distinguished Professor, National Chung Hsing University.

2014~ , Joint Appointment Professor, Ph.D. Program in Translational Medicine, National Chung Hsing University.

2014~ , Joint Appointment Professor, Ph.D. Program in Medical Biotechnology, National Chung Hsing University.

2014~ , Chairman, Taiwan Genomics and Genetics Society.

2013-2016, Director, Rong Hsing Research Center for Translational Medicine, National Chung Hsing University.

2010-2013, Distinguished Professor and Director, Institute of Biomedical Sciences, National Chung Hsing University.

2011-2014, Director, Taiwan Genomics and Genetics Society.

2010-2013, Joint Appointment Professor, Graduate Institute of Integrated Medicine, China Medical University.

2008-2019, Distinguished Professor, National Chung Hsing University.

2008-2011, Secretary-General, Taiwan Genomics and Genetics Society.

2007-2010, Professor and Director, Institute of Biomedical Sciences, and Institute of Medical Technology, National Chung Hsing University.

2006-2008, Division Head, Research Division, Biotechnology Center, National Chung Hsing University.

2005-2007, Adjunct Associate Professor, Institute of Clinical Medicine, National Taiwan University College of Medicine.

2004-2007, Associate professor, Institutes of Biomedical Sciences and Molecular Biology, National Chung Hsing University.

2002-2011, Co-Principal Investigator, Microarray Core Facility for Genomic Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine. (NSC support)

2002-2004, Assistant professor, Institute of Biomedical Sciences, National Chung Hsing University.

2002-2003, Research consultant, Department of Medical Research, National Taiwan University Hospital.

2001-2005, Adjunct Assistant Professor, Institute of Clinical Medicine, National Taiwan University College of Medicine.

2000-2002, Assistant Research Fellow, Department of Medical Research, National Taiwan University Hospital.

2000-2002, Principal Investigator, Microarray Core Facility, National Taiwan University Hospital.

1998-2000, The army medical officer, Hua-Lian, the Ministry of National Defense, the Republic of China.

Professional Society:

The active membership of the American Association for Cancer Research

Editorial board member for American Journal of Cancer Research

Editorial board membership of MicroRNA journal

Editorial board/academic editor of PLOS ONE journal

Editorial board member of International Journal of Biochemistry and Molecular Biology Research

Chairman, Taiwan Genomics and Genetics Society

Research Areas

1.Molecular tumor biology: To explore the molecular mechanism of tumorigenesis and cancer metastasis by using advanced molecular biology approaches, including microarray and next-generation sequencing technologies.

2.Signal transduction: To investigate the interaction between cancer cell and stroma cell (or microenvironment) by microarray, as well as the signaling pathways.

3.Clinical application: To develop the molecular classification, diagnosis, and prognosis of cancer, as well as the evaluation of patient-tailored cancer treatment.

4.Bioinformatics: To develop bioinformatics tools and algorithm, including the data analyses of microarray, pathway, cis-regulatory element, transcription factor, next-generation sequencing, and so on.

5.Anti-cancer drug screening and functional analysis for NSCLC.

　To resolve the complex genetic network and understand the living phenomenon, it should be started from the function of many genes. That means the end of Human Genome Project opens another new age, that is post-genome era. Function genome analysis is also thought to be one of the most potential research projects in twenty-first century after human genome project. Some new and foresighted biological chip techniques were developed in these years, for example, cDNA microarray, DNA chip, protein array, Lab-on-a-chip, CpG island microarray, cell-based microarray, and so on, which are exploring the function of many genes in accelerative. Therefore, it is not difficult to realize that the progress of molecular biology is very closely linked the search of novel genes. cDNA microarray is one of the more mature biochip techniques and has been widely applied to identify novel genes in many fields. It is also anticipated that microarray will be applied to improve disease diagnosis, disease classification, prognosis evaluation and to improve treatment outcome.

　　Under the framework of microarray core technology, our main research aspects are as follows: (1). To develop new microarray technology and apply to biomedical sciences and agriculture. Lab has established human and mouse cDNA microarray membrane. Presently, we are developing cell-based microarray and constructing plant microarray for the applications of biomedical sciences and agriculture, such as gene regulation, drug action, and the identification of active ingredient related genes for Chinese herb medicine. (2). To explore the molecular mechanism of cancer metastasis. In previous study, we have identified 600 invasion/metastasis-related genes from established lung cancer model cell lines of metastasis using microarray. One of them has been characterized as a novel gene in invasion/metastasis and correlated closely with clinical metastasis. We will investigate the roles of these identified genes in metastatic process; furthermore profile their downstream genes to interpret the molecular mechanism of metastasis. (3). To dissect the complicated multi-step process of metastasis that involve interactions between cancer cells and their surrounding stroma (or microenvironment). Metastasis is a complicated multi-step process which involves the degradation of the basement membrane and invasion of the stroma by endothelial cells, which then proliferate, migrate, and become organized into a capillary structure. We will profile the gene expressions of interactions between cancer cells and stroma to interpret the molecular mechanism of angiogenesis and metastasis. (4). Study on Pharmaco-genomics. By using microarray, we can analyze the drug response and action mode to develop the screening platform or evaluating criteria of new drug discovery. (5). To develop the molecular classification, diagnosis, and prognosis of diseases and the evaluating criteria of patient-tailored disease treatment. By means of profiling gene expression patterns of disease specimens and correlating with clinical outcome, the differentially expressed gene or sets of genes distinguishable to drug response or clinical information will be identified. The results may be used to develop diagnostic chips of patient-tailored disease treatment, which can avoid the unnecessary treatment and wasting resources. (6). To develop algorithm and bioinformatic tools. In addition to the mentioned above, to establish the integration of microarray analysis from the upstream chip fabrication to the downstream pathway analysis as well as to improve/speed up the efficiency of data analysis, we developed algorithm and bioinformatic tools such as BiochipWeb and SpecificDB. BiochipWeb is a web-based tool for microarray data analysis that supports re-scale normalization, data adjustment, data filtration, standard normalization, ANOVA, SOM clustering, and pathway analysis. The integrated and web-based software, SpecificDB, has been also established and applied to design the appropriate probe, siRNA and primer sets for the HGI, based on our algorithm. SpecificDB is a web database that integrated KEGG and BioCarta pathway databases, gene ontology database, human putative promoter database, transcription factor database TRANSFAC 9.3, and our INT-ANN-BLAST algorithm. By using these tools, we can apply the huge amount of data from microarray analysis to predict the regulatory pathways of interests or other metastasis-related genes.

　　Currently, all the research aspects described above are proceeding, a part of works have had fruitful results even published. It can be anticipated that there will be more extensive and thorough information obtained from above to interpret the molecular mechanism of metastasis and develop prediction and diagnosis strategies of disease. In addition, these researches will also expand the application categories of microarray technology.

Honor 

Project for MOST research fellow, Ministry of Science and Technology, Taiwan, R.O.C., 2018-2021.

Outstanding Research Award, National Science Council, Taiwan, R.O.C., 2010-2013.

Outstanding Research Award, National Science Council, Taiwan, R.O.C., 2007-2010.

Distinguished Scholar Research Project grants, National Science Council, Taiwan, R.O.C., 2009-2012.

“50 Scientific Achievements”, National Science Council, Taiwan, R.O.C., 2009.

Technology Transfer Outstanding Contribution Award, National Science Council, Taiwan, R.O.C., 2008.

National Science Council Research Award, Taiwan, R.O.C., 2001.

Taiwan Cancer Medical Contribution Award, 16th Taiwan Joint Cancer Conference, 2011.

Tenured Distinguished Professor, National Chung-Hsing University, Taiwan, R.O.C., 2018.

Honorary Distinguished Professor, National Chung-Hsing University, Taiwan, R.O.C., 2013.

“The Honor of the Chung-Hsing University” Significant Contribution Award, National Chung-Hsing University, Taiwan, R.O.C., 2010.

Research Project Merit Award, National Chung-Hsing University, Taiwan, R.O.C., 2010.

Distinguished Professor, National Chung-Hsing University, Taiwan, R.O.C., 2008.

Research Performance Award, National Chung-Hsing University, Taiwan, R.O.C., 2006 and 2007.

“The Honor of the Chung-Hsing University” Significant Contribution Award, National Chung-Hsing University, Taiwan, R.O.C., 2006.

Junior Faculty Research Award, National Chung-Hsing University, Taiwan, R.O.C., 2006.

European Society of Human Reproduction and Embryology (ESHRE). 19th Annual Meeting of ESHRE - Madrid, Spain, June 29-July 2, 2003. Poster Outstanding Award.

European Society of Human Reproduction and Embryology (ESHRE). 17th Annual Meeting of ESHRE -Lausanne, Switzerland, July 1-5, 2001. Poster Outstanding Award.

“Dr. Chien-Tien Hsu’s Award Presentation“, Sixth Symposium on Recent Advances in Cellular and Molecular Biology, KenTing, February 21 to 23, 1998. Excellent Award.

Course

Biochip technology、Advanced Biomedical Research Based Learning、Molecular Oncology、Research Methods for Biomedical Technology、 Seminar for graduate student、Special Topics in Tumor Metastasis、Special Topics in the Interactions Between Cancer Cells and Microenvironment、 Scientific Paper Writing、Genomic Translational Medicine、Experiments in Genomics、Special Topics in Oncogenomics、Biomedical Research Based Learning、 New Technologies and Applications of Biomedical Sciences