Student: Kolby Black
Project Mentors: Dr. Christopher Buneo – SBHSE
Dr. Rosalind Sadleir – SBHSE
Dr. Ben Hendricks – Barrow Neurological Institute
YouTube Link: View the video link below before joining the zoom meeting
Zoom link: Zoom Link: https://asu.zoom.us/j/96677610858?pwd=NVdxR0tBVzZKa0hzQng4STJISFV3QT09
Zoom Password: 611849
Abstract
Alternating electric field therapy has been previously shown to impact glioblastoma growth in human patients. The current delivery method of this therapy is limited by adverse events such as scalp irritation and patient inconvenience. This project investigates the potential of adapting this effective treatment for glioblastoma into an implantable system. This system would eliminate irritation and inconvenience, and potentially provide more effective results when compared to the current external device. The project investigated the potential of implantation by: (1) simulation of an alternating electric field in a finite element model, and (2) the implantation and recording of electric fields in a cadaveric model. The finite element model showed a significant decrease in voltage requirement compared to the existing transcranial device. This was confirmed in the cadaveric model as a linear relationship between electric field strength and input voltage was verified. A peak to peak source voltage of approximately 0.4 to 0.6 Vpp was required to generate a 0.7 V/cm electric field.