Student: Jordan Todd
Project Mentors: Dr. Sarah Stabenfeldt – SBHSE
Dr. Brent Vernon – SBHSE
Dr. Rachel Sirianni – SBHSE
YouTube Link: View the video link below before joining the zoom meeting
Zoom Link: https://asu.zoom.us/j/94357387534
Zoom meeting time: 10am - noon
Abstract
Due to the extensive treatment challenges associates with traumatic brain injury (TBI), this study created a nanoparticle to evaluate the pharmacokinetics/pharmacodynamics associated with drug delivery in a compromised blood-brain barrier. Loperamide encapsulated poly(lactic acid)-poly(ethylene glycol) (PLA-PEG) nanoparticles were fabricated for the future assessment of blood-brain barrier permeability. The nanoparticles were produced using the NanoAssemblr® microfluidic system, and a design of experiments optimized the parameters of flow rate, ratio of aqueous to organic solvents, and polymer and drug concentrations. These parameters were evaluated through size, polydispersity, zeta potential, and encapsulation efficiency. The study was concluded with a literature review for optimizing the particles with respect to encapsulation efficiency.