Prevalence and Incidence

Huntington Disease, HD

Prevalence

• United States

The prevalence of HD is estimated at approximately 5-10 cases per 100,000 people in populations of European descent.

• Globally

The prevalence of HD varies significantly based on geographic and ethnic factors:

• Highest prevalence: Populations of European ancestry show rates similar to those in the U.S.

• Lower prevalence: Asian and African populations have much lower rates, typically <1 case per 100,000 people, due to differences in the genetic mutation's occurrence.

Incidence: 

• United States: The incidence rate is estimated at 0.38–0.46 new cases per 100,000 person-years.

• Globally: Incidence rates show a similar pattern to prevalence, with higher rates in populations of European descent and significantly lower rates in Asian and African populations.

It is important to note that Huntington’s Disease does not show a significant difference in prevalence or incidence between males and females. Both genders are equally affected since the HD gene is located on an autosomal chromosome (chromosome 4) and follows an autosomal dominant inheritance pattern