Ray Wu was a student at Yenching University when the escalating civil war in China forced his family to emigrate to the United States in 1948. There, his father, biochemist Hsien Wu, secured a faculty position at the University of Alabama. Ray Wu pursued further studies in biochemistry at the University of Pennsylvania, later joining Cornell University, where he developed and performed the first technique in DNA sequencing. Despite the challenges of being a minority and not receiving credit for his contributions, Wu's work laid the groundwork for modern DNA sequencing methods. Outside of his scientific endeavors, Ray Wu enjoyed spending time with family and friends and had a passion for music and photography.
In the 1970s, Ray Wu developed the primer-extension method for DNA sequencing, a technique that involved unzipping lambda bacteriophage DNA and extending the overhanging ends with radioactive labels. This method significantly advanced the field of genomics by allowing precise identification of DNA sequences. Despite his groundbreaking work, Ray Wu's contributions have often been overshadowed in the broader narrative of DNA sequencing history, receiving less attention than those of his contemporaries. Later in his career, Ray Wu developed genetically modified rice that was resistant to pests, drought, and salts. He also served as an adviser to both the U.S. and Chinese governments.