Peptidomimetic chemistry
CTB-Morph
CTB-Morph
Conceptually, this software package allows a semi-automatic development of a peptidimimetic from a peptide. The necessary input is peptide sequence and structure of a protein-peptide or protein-protein interaction. Natural peptides are very important chemical tools for target validation, and might even represent potential drug candidates, however, it is often not easy to develop a natural peptide with the necessary high affinity and stability, while specificity is often achieved. The complete set of worldwide commercially available non-natural amino acids, amino-carboxylic acids and di-acids and amines are the input information for the position specific replacement of natural amino acids.
Conceptually, this software package allows a semi-automatic development of a peptidimimetic from a peptide. The necessary input is peptide sequence and structure of a protein-peptide or protein-protein interaction. Natural peptides are very important chemical tools for target validation, and might even represent potential drug candidates, however, it is often not easy to develop a natural peptide with the necessary high affinity and stability, while specificity is often achieved. The complete set of worldwide commercially available non-natural amino acids, amino-carboxylic acids and di-acids and amines are the input information for the position specific replacement of natural amino acids.
