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Dr. A. Jeyaprakash Arulanandam - "Targeting Survivin, Ska1 and other protein-protein interactions in cancer"
Dr. A. Jeyaprakash Arulanandam - "Targeting Survivin, Ska1 and other protein-protein interactions in cancer"
The Auer lab has a key interest in targeting so far unexplored or high value protein-protein interaction targets in cancer. This includes targets that are crucial for proper chromosomal segregation during cell division. These targets, such as the Ska complex, are the expertise of the Arulanandam (JP) lab.
The Auer lab has a key interest in targeting so far unexplored or high value protein-protein interaction targets in cancer. This includes targets that are crucial for proper chromosomal segregation during cell division. These targets, such as the Ska complex, are the expertise of the Arulanandam (JP) lab.
The JP lab is situated on the Kings building campus and is part of the Wellcome Trust Centre for Cell Biology.
The JP lab is situated on the Kings building campus and is part of the Wellcome Trust Centre for Cell Biology.
JP’s lab research interests lie in the mechanisms behind chromosomal segregation, and the error-free distribution of genetic material from one generation of cells to the next. Defective segregation leads to chromosomal instability (CIN), which has direct implications in carcinogenesis. JP’s group studies the biology behind this process by the identification and characterisation of protein-protein interactions which play essential roles in accurate chromosomal segregation during mitosis.
JP’s lab research interests lie in the mechanisms behind chromosomal segregation, and the error-free distribution of genetic material from one generation of cells to the next. Defective segregation leads to chromosomal instability (CIN), which has direct implications in carcinogenesis. JP’s group studies the biology behind this process by the identification and characterisation of protein-protein interactions which play essential roles in accurate chromosomal segregation during mitosis.
The JP group’s research has resulted in a wealth of knowledge with regards to protein purification, crystallography and development of functional assays to assess protein function. This expertise proves invaluable to the Auer group when working with targets involved in mitosis. Additionally research conducted by the Auer group allows the progression of targets to translational science, and provides tool compounds of interest to both groups.
The JP group’s research has resulted in a wealth of knowledge with regards to protein purification, crystallography and development of functional assays to assess protein function. This expertise proves invaluable to the Auer group when working with targets involved in mitosis. Additionally research conducted by the Auer group allows the progression of targets to translational science, and provides tool compounds of interest to both groups.
This mutually beneficial workflow has led to a natural collaboration between the Auer and JP groups.
This mutually beneficial workflow has led to a natural collaboration between the Auer and JP groups.
JP Group Website – http://jeyaprakash.bio.ed.ac.uk/
JP Group Website – http://jeyaprakash.bio.ed.ac.uk/
Wellcome Senior Research Fellow
Wellcome Trust Centre for Cell Biology
University of Edinburgh
Michael Swann Building
Max Born Crescent
Edinburgh
EH9 3BF
Key Publications JP Lab
Key Publications JP Lab
Abad MA, Zou J, Medina-Pritchard M, Nigg EA, Rappsilber J, Santamaria A and Jeyaprakash AA. (2016) Ska3 Ensures Timely Mitotic Progression by Interacting Directly with Microtubules and Ska1 Microtubule Binding Domain. SciRep. 6, 34042; doi: 10.1038/srep34042.
Abad MA, Zou J, Medina-Pritchard M, Nigg EA, Rappsilber J, Santamaria A and Jeyaprakash AA. (2016) Ska3 Ensures Timely Mitotic Progression by Interacting Directly with Microtubules and Ska1 Microtubule Binding Domain. SciRep. 6, 34042; doi: 10.1038/srep34042.
Jeyaprakash AA, Santamaria A, Jayachandran U, Chan YW, Benda C, Nigg EA and Conti E. (2012) Structural and Functional Organization of the Ska Complex, a Key Component of the Kinetochore-Microtubule Interface. Mol Cell. May 11;46(3):274-286. Epub 2012 Apr 5.
Jeyaprakash AA, Santamaria A, Jayachandran U, Chan YW, Benda C, Nigg EA and Conti E. (2012) Structural and Functional Organization of the Ska Complex, a Key Component of the Kinetochore-Microtubule Interface. Mol Cell. May 11;46(3):274-286. Epub 2012 Apr 5.
Jeyaprakash AA§, Basquin C, Jayachandran U, Conti E§. (2011) Structural Basis for the Recognition of Phosphorylated Histone H3 by the Survivin Subunit of the Chromosomal Passenger Complex. Structure. Nov 09;19(11):1625-34. Epub 2011 Oct 25 (§Corresponding Authors)
Jeyaprakash AA§, Basquin C, Jayachandran U, Conti E§. (2011) Structural Basis for the Recognition of Phosphorylated Histone H3 by the Survivin Subunit of the Chromosomal Passenger Complex. Structure. Nov 09;19(11):1625-34. Epub 2011 Oct 25 (§Corresponding Authors)
Jeyaprakash AA*, Klein UR*, Lindner D, Ebert J, Nigg EA, Conti E. (2007) Structure of a Survivin-Borealin-INCENP Core Complex Reveals How Chromosomal Passengers Travel Together. Cell. Oct 19;131(2):271-85. (*equal contribution)
Jeyaprakash AA*, Klein UR*, Lindner D, Ebert J, Nigg EA, Conti E. (2007) Structure of a Survivin-Borealin-INCENP Core Complex Reveals How Chromosomal Passengers Travel Together. Cell. Oct 19;131(2):271-85. (*equal contribution)
Prof. Walter Kolch - "Targeting protein-protein interaction in oncogenic pathways, like EGFR, Her2, Systems biology"
Prof. Walter Kolch - "Targeting protein-protein interaction in oncogenic pathways, like EGFR, Her2, Systems biology"
SBI Director
UCD Conway Institute
Dublin 4
Ireland
http://www.ucd.ie/research/people/conwayinstitute/professorwalterkolch/
Prof Achim Schnaufer - "Targeting Rel-1"
Prof Achim Schnaufer - "Targeting Rel-1"
We collaborate with the lab of Achim Schnaufer on drug discovery for trypanosomatid parasites. These important pathogens of humans and their livestock depend on a unique form of post-transcriptional RNA editing, and the Schnaufer lab has used high-throughput screening of small compound libraries to identify inhibitors of a key editing enzyme, RNA editing ligase 1. Jointly scientists of the Schnaufer and the Auer labs, particularly, Zandile Nare, a PhD student in the Schnaufer lab, have developed a variation of the CONA on-bead screening assay platform which is now focused on identification of the mode of action of HTS hits.
We collaborate with the lab of Achim Schnaufer on drug discovery for trypanosomatid parasites. These important pathogens of humans and their livestock depend on a unique form of post-transcriptional RNA editing, and the Schnaufer lab has used high-throughput screening of small compound libraries to identify inhibitors of a key editing enzyme, RNA editing ligase 1. Jointly scientists of the Schnaufer and the Auer labs, particularly, Zandile Nare, a PhD student in the Schnaufer lab, have developed a variation of the CONA on-bead screening assay platform which is now focused on identification of the mode of action of HTS hits.
Achim Schnaufer webiste: http://schnauferlab.bio.ed.ac.uk/
Achim Schnaufer webiste: http://schnauferlab.bio.ed.ac.uk/
Address
Centre for Immunity, Infection & Evolution
Institute of Immunology & Infection Research
University of Edinburgh
King's Buildings, Ashworth Laboratories
Charlotte Auerbach Road
Edinburgh EH9 3FL
http://schnauferlab.bio.ed.ac.uk
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