From NORD:  Disease Overview

"Myasthenia gravis is a neuromuscular disorder primarily characterized by muscle weakness and muscle fatigue. Although the disorder usually becomes apparent during adulthood, symptom onset may occur at any age. The condition may be restricted to certain muscle groups, particularly those of the eyes (ocular myasthenia), or may become more generalized (generalized myasthenia gravis), involving multiple muscle groups.

"Most individuals with myasthenia gravis develop weakness and drooping of the eyelids (ptosis); weakness of eye muscles, resulting in double vision (diplopia); and excessive muscle fatigue following activity. Additional features commonly include weakness of facial muscles; impaired speech (dysarthria); difficulties chewing and swallowing (dysphagia); and weakness of the upper arms and legs (proximal limb weakness). In addition, in about 10 percent of patients, affected individuals may develop potentially life-threatening complications due to severe involvement of muscles used during breathing (myasthenic crisis).

"Myasthenia gravis results from an abnormal immune reaction in which the body’s natural immune defenses (i.e., antibodies) inappropriately attack and gradually injure certain receptors in muscles that receive nerve impulses (antibody-mediated autoimmune response)."

History of Myasthenia Gravis Revisited (NIH)

An interesting video: Myasthenia Gravis: A History Lesson.  Henry Kaminski, MD, Professor of Medicine at The George Washington University, provides a brief history lesson on our understanding of myasthenia gravis.

International Consensus Guidance for Management of Myasthenia Gravis - 2020 Update

These MG treatment guidelines are the result of a three-year effort to develop agreement among an international group of MG experts on the use of various treatments for people with MG. These guidelines were developed with leadership from our MGFA Medical and Scientific Advisory Board members and published in the November 3, 2020 issue of Neurology. This paper is a significant new resource for physicians caring for MG patients.

*NEW* Keys to an Early Diagnosis of Miller Fisher Syndrome: A Case of Miller Fisher Syndrome Masquerading as Myasthenia Gravis (Cureus) From the Abstract: "Miller Fisher syndrome (MFS) and myasthenia gravis can present with similar symptoms. However, some key differences can help differentiate between these two disorders. Early identification is extremely important for MFS so treatment can be initiated in a timely manner. Here, we present the case of a 33-year-old female who was initially diagnosed with myasthenia gravis and was later found to have MFS. The goal of this case report is to provide information to aid in the early diagnosis and identification of MFS."

🔥🔥🔥If you've been looking for a primer on what the heck is going on at the nerve-muscle junction in Myasthenia Gravis, then I highly recommend the following two YouTube videos, watched in order, to help you understand some of the complexities in MG.  Some basic high school biology background (specifically neurology) might help.

•  Neuromuscular Junction (watch first)

•  Myasthenia Gravis (watch second)

Other Useful Information

Causes of Muscle Twitches and Spasms  (WebMD)

Muscle Weakness in Adults: Evaluation and Differential Diagnosis  (American Family Physician)

Relationship between hearing function and myasthenia gravis: A contemporary review (NIH)