General Sources & Summaries

• Hot MG Research News (MGFA)

• American Journal of Managed Care (AJMC) Search for "Myasthenia Gravis" 

• Vol. 4 No. 3 (2023): Proceedings of the MGFA International Conference (KU)

• Overview of MG Research and Clinical Trials (Conquer MG)

• MG Research (NIH via PubMed)

Complement

• Newly discovered mechanisms of action by Soliris (Eculizumab) may improve treatment outcomes (unboundmedicine)

• Role of complement in myasthenia gravis (Frontiersin)

• Myasthenia gravis: the role of complement at the neuromuscular junction (New York Academy of Sciences)

• Complement and its role in innate and adaptive immune responses (Cell Research)

• Complement and myasthenia gravis  (Molecular Immunology)

• Complement Activation Profile in Myasthenia Gravis (NIH)

COUR, CAR-T and Other RNA/DNA-based Studies

• *NEW* COUR (MGFA/YouTube) "Reprogramming the Immune System to Halt Myasthenia Gravis"

• A better way to make RNA drugs: Enzymatic synthesis method expands capabilities while eliminating toxic byproducts (Weiss)

• Descartes-08

• FDA OKs clinical testing of new cell therapy for hard-to-treat gMG (Myasthenia Gravis News)

• First Patient Dosed in First-In-Human Phase 1 Trial of Next-Generation mRNA CAR-T Cell Therapy Descartes-15 (BioSpace)

Povetacicept

• Povetacicept shows promise in MG mouse model (Myasthenia Gravis News)

• Press Release (Business wire)

• Povetacicept may be superior to current MG treatments: Early study (Myasthenia gravis News)

Quality of Care and Patient Support

• UK Study: Most Patients With MG Require Hospitalization, Driving Health Care Resource Use (AJMC)

• Real world study on prevalence, treatment and economic burden of myasthenia gravis in Italy  (Heliyon)

• How physicians with poor knowledge of MG might affect care of MG patients (unboundmedicine) - subscription required

• People Diagnosed with Myasthenia Gravis have Lower health-related quality of life and Need More Medical and Caregiver Help in Comparison to the General Population (unboundmedicine) - subscription required

• Healthcare resource use in myasthenia gravis: a US health claims analysis  (PubMed)

• How characterizing Social Determinants Of Health burden can help improve the design of patient support programs (unboundmedicine) - subscription required

• Results from the MyRealWorld MG study (unboundmedicine) - subscription required

• An innovative partnership between Alexion, AstraZeneca Rare Disease and patients (unboundmedicine) - subscription required

Mental Health

• Depression: A Contributing Factor to the Clinical Course in Myasthenia Gravis Patients (MDPI)

• Mental Health Toll Reported in Patients With Myasthenia Gravis (rarediseaseadvisor)

• Patients With MG Have High Levels of Neuroticism, Study Finds (rarediseaseadvisor)

• Personality factors in patients with myasthenia gravis: A prospective study (onlinelibrary)

• Personality traits in MG patients may underlie depression, anxiety (Myasthenia Gravis News)

• Scientists Discover “Startling” Levels of Hidden Mental Health Symptoms Among Autoimmune Disease Patients (SciTechDaily)

Others

• *NEW* Phase 1 trial of NKX019 cell therapy in gMG patients cleared to open (Myasthenia Gravis News)

• Pro-inflammatory cytokines in myasthenia gravis: a systematic review and meta-analysis (PubMed)

• Worsening of myasthenic symptoms associated with statins (PubMed)

• Real-world experience with eculizumab and switching to ravulizumab for generalized myasthenia gravis (Wiley)

• Abnormalities of Otoacoustic Emissions in Myasthenia Gravis: Association With Serological and Electrophysiological Features (Frontiers in Neurology) Results of this research that suggest a test for the ears that might improve the "diagnostic certainty of MG and help to monitor its severity".

• Taste disorders and alopecia in myasthenia gravis (BMC Neurology)

• Neurometabolic and Brain Functional Alterations Associated with Cognitive Impairment in Patients with Myasthenia Gravis: A Combined 1H-MRS and fMRI Study (PubMed)

• Patient perceptions of disease burden and treatment of myasthenia gravis based on sentiment analysis of digital conversations (Nature) - An analysis of "...public domain digital conversations about MG..." from online sources such as MG forums and social media.

• What's on the Horizon for Myasthenia Gravis  (MedPage Today)

• Antigenic mimicry of ubiquitin by the gut bacterium Bacteroides fragilis: a potential link with autoimmune disease (Clinical and Experimental Immunology)

• MicroRNAs in blood may help diagnose ocular MG, study suggests (Myasthenia Gravis News) (here is the original study article)

• Diagnosis and Management of Seronegative Myasthenia Gravis: Lights and Shadows (mdpi)

• Plasma Exchange versus Intravenous Immunoglobulin in Worsening Myasthenia Gravis: A Systematic Review and Meta-Analysis with Special Attention to Faster Relapse Control (mdpi)

• Precision targeting of autoantigen-specific B cells in muscle-specific tyrosine kinase (MUSK) myasthenia gravis with chimeric autoantibody receptor T cells (Nature)

• Lack of exercise may play a role in the development of MG (NIH)

• Peripheral immune landscape for hypercytokinemia in myasthenic crisis utilizing single-cell transcriptomics (translationalmedicine)

• In Myasthenia Gravis, Antibodies Pass Open-Label Tests (Medscape)  - subscription required

• GRO Biosciences’ ProGly platform shows promise in MG animal model (Myasthenia Gravis News)

• The ME&MG Digital Solution for Autonomous Assessment of Myasthenia Gravis (Center watch.com)

• FLEX Study (to test the effectiveness and safety of batoclimab, the investigational injectable medication)

• Myasthenic crisis in thymoma-associated myasthenia gravis: a multicenter retrospective cohort study (nmd-journal)

• Addressing Outcome Measure Variability in Myasthenia Gravis Clinical Trials (Neurology.org)

• Recipharm, Ahead team up to develop new treatment for MG (Myasthenia Gravis News)