11th STEROIDS and NERVOUS SYSTEM MEETING
SCIENTIFIC PROGRAM
Attention: Hours are in Italy Local Time (CET)
Saturday, February 19, 2022
14:00-14:30: Opening
14:30-15:30: Plenary Lecture (Chair: J.Balthazart, Belgium)
Karyn M. Frick (USA)
Rapid mechanisms of estrogenic memory modulation
15:30-16:00: coffee break
16:00-18:00: ESTROGENS AND THE BRAIN: THE GOOD, THE BAD AND THE FRANKLY PUZZLING
Chair: Sohrabji F. (USA), Galea L. (Canada)
Choleris E. (Canada)
Estrogens affect short term social recognition memory in various brain regions in a receptor-dependent manner: Unraveling the mechanisms
Saldanha C. (USA)
Spatial and temporal specificity of neuroestradiol provision in the songbird
Sohrabji F. (USA)
Estrogens effects on stroke neuroprotection: lessons learned from gut microbiota and gut metabolites
Sacher J. (Germany)
Does endogenous estradiol protect the female brain from metabolic harm during midlife?
Sunday, February 20, 2022
9:00-13:30: ALDOSTERONE AND GLUCOCORTICOIDS IN HEALTH AND DISEASE
Chair: Jezova D. (Slovaki ), Krugers H. (NL), Meijer O. (NL)
9:00-9:30: free communications
Mancini G.F. et al. (NL)
Late glucocorticoid receptor antagonism counteracts the programming effects of brief and repeated social isolation stress in early-adolescent rats.
Tsimpolis A. et al. (Greece)
Study of the dynamic effects of glucocorticoid pulsatility on brain-derived neurotrophic factor expression in astrocytes
9:30-13:30: invited lectures
Hlavacova N. (Slovakia)
Aldosterone and mental functions-Evidence obtained in animal models
Jezova D. (Slovakia)
Role of aldosterone in the pathophysiology of affective disorders
Jeanneteau F. (France)
Glucocorticoids and dendritic spine plasticity: Context matters!
11:00-11:30: coffee break
Binder E. (Germany)
Massively parallel enhancer screens identify genetic variants that moderate the transcriptional response to glucocorticoids and are causally related to psychiatric disorder
de Quervain D. (Switzerland)
Stress, genes and memory: implications for treating fear-related disorders
Lesuis S. (Canada)
Disruption of memory allocation by stress: a role for parvalbumin interneurons and endocannabinoid signaling
Murck H. (Germany)
Aldosterone and BMI related brain morphology and treatment outcome in patients with major depression
13:30-15:00: lunch
15:00-18:00: NEUROSTEROIDS IN ANALGESIA AND ANESTHESIA
Chair: Todorovic S.M. (USA), Melcangi R.C. (Italy)
15:00-17:00: invited lectures
Jevtovic-Todorovic V. (USA)
Novel neurosteroids as safe general anesthetics for young
Todorovic S.M. (USA)
Novel neurosteroids and perioperative analgesia
Gonzales S. (Argentina)
Neuroactive steroids and central neuropathic pain
Meyer L. (France)
Analgesic and neuroprotective effects of neurosteroids against chemotherapy-induced neuropathic pain
17:00-17:30: coffee break
17:30-18:00: free communications
Deligiannidis, K.M. et al. (USA)
Safety and tolerability profile of Zuranolone from the landscape (major depressive disorder) and nest (postpartum depression) clinical development programs
Milivojevic V. et al. (USA)
The neuroactive steroid precursor pregnenolone reduces stress and cue- provoked alcohol craving, and normalizes hpa axis and autonomic arousal responses in individuals with alcohol use disorder
18:00-19:00: posters' discussion
Monday, February 21, 2022
9:15-10:30: Free theme communications
Chair: Giatti S., Gotti S. (Italy)
Felipo V. et al. (Spain)
GR3027, A GABAA receptor modulating steroid antagonist, reverses neuroinflammation in cerebellum and restores motor coordination in hyperammonemic rats
Corsi S. et al. (Italy)
Pregnenolone for the treatment of L-DOPA-induced dyskinesia in Parkinson’s disease
Sliwowska J. et al. (Poland)
Do males and females respond differently to obesity and diabetes? Lesson from animal models
Cengiz P. et al. (USA)
Sexually differential role of estrogen receptor alpha and TRKB receptor in long-term neuroprotection following neonatal brain injury
Lasser, R. et al. (USA)
Summary of early (day 2/3) and primary (day 15) clinical efficacy outcomes from the ongoing clinical development program for Zuranolone in the treatment of major depressive disorder and postpartum depression
10:30-11:00 Coffee break
11:00-13:00: BIOLOGICAL INTERACTIONS BETWEEN STEROIDS AND THE ENDOCANNABINOID SYSTEM: POTENTIAL ROLE IN HEALTH AND DISEASE
Chair: Vallée M. (France), Frau R. (Italy)
Melis M. (Italy)
Mesolimbic dopamine dysregulation as a signature of aberrant salience attribution imposed by prenatal THC exposure
Vallée M. (France)
The neurosteroid pregnenolone as a new endogenous regulator of cannabinoid receptor type 1 (CB1): therapeutic relevance for cannabis abuse and cognitive disorders
Hill M.N. (Canada)
Endocannabinoid-Glucocorticoid Interactions in the Regulation of Feeding and Metabolism
Pinna G. (USA)
Biomarkers and treatments for mood disorders at the interface of the neurosteroid and endocannabinoid systems.
13:00-14:00: lunch
14:00-17:00: REGULATION OF LEARNING STRATEGIES BY SEX STEROIDS IN MALES AND FEMALES
Chair: Spritzer M. (USA), Cornil C. (Belgium)
14:00-16:00: invited lectures
Spritzer M. (USA)
Dose-dependent effects of testosterone on spatial learning strategies in male rats
Korol D. (USA)
Starring role of astrocytes in estradiol-mediated shifts in learning strategy.
Brake W. (Canada)
The Role of Estrogens and Progesterone on Memory System Bias
Toufexis D. (USA)
Sex differences in the formation and modulation of habitual behavior
16:00-16:30: coffee break
16:30-17:00: Free communications
Abi-Ghanem C. et al. (USA)
Influence of androgens on a mouse model of multi-etiology dementia
Borbélyová V. et al. (Slovakia)
The effect of estrogen deprivation on the behavior of shank 3-deficient mouse model of autism
17:00-18:30: SEX DIFFERENCES, APOE, AND ALZHEIMER’S DISEASE
Chair: Pike C. (USA), Garcia-Segura L.M. (Spain)
Balu D. (USA)
Understanding the increased risk fo11r Alzheimer’s disease in female APOE4 carriers: what we have learned from the EFAD-transgenic mouse model
Pike C. (USA)
Sex and sex steroids modulate the interactions between APOE genotype and Alzheimer’s
Taxier L. (USA)
Influence of sex, APOE genotype, and 17-beta estradiol on memory and neural function in the EFAD transgenic model of Alzheimer’s disease
Tuesday, February 22, 2022
9:30-11:00: RECENT ADVANCES IN UNDERSTANDING THE ROLE OF ESTROGEN RECEPTOR BETA IN BEHAVIOUR
Chair: Ogawa S. (Japan), Barreto G. (Ireland)
Ogawa S. (Japan)
Estrogen Receptor beta neural network in the regulation of social behaviors.
Vasudevan N. (UK)
Nongenomic signaling can drive behaviour via membrane-bound receptors
Xiao-Hong X. (China)
Esr1 signaling models aggression circuit wiring during neonatal critical period
11:00-11:30: coffee break
11:30-12:30: Young Investigators Symposium
Chair: Giatti S., Gotti S. (Italy)
Bonaldo B. et al. (Italy)
Mother and son: how Bisphenols target brain and behaviors
Brand B.A. et al. (the Netherlands)
Raloxifene as adjunctive treatment for schizophrenia-spectrum disorders: A Double-Blind, Randomized, Placebo-Controlled Trial
Cabrera Zapata L. et al. (Spain)
Role of the X-linked histone demethylase KDM6a in sex-specific differentiation of hypothalamic neurons
De Wit A. et al. (the Netherlands)
Oral contraceptives and depression in healthy women: causal relation or just a correlation?
Demetriou A. et al. (Sweeden)
The impact of estrogen receptor beta on microglia activation and Alzheimer’s disease pathology
McGovern A. et al. (Ireland)
Sex differences in mitochondrial metabolism from a proteomic analysis of a gonadectomised and tibolone treated mouse model
12:30-13:30: lunch
13:30-15:30: posters' discussion
15:30-16:30: GENE REGULATION BY STEROID HORMONE RECEPTORS: MOLECULAR INSIGHTS INTO PHYSIOLOGY AND BEHAVIOR
Chair: Tollkunn J. (USA), Frick K. (USA)
Kundakovic M. (USA)
Epigenetic regulation of brain and behavior by the estrous cycle
Tollkuhn J. (USA)
Hormonal regulation of sex-variable gene expression
16:30-17:30: Plenary Lecture (Chair: Krugers H., NL)
Onno C. Meijer (Netherlands)
Brain glucocorticoid receptors & stress: finding specificity in the midst of pleiotropy
17:30-18:00: Closure