Herbison A. (New Zealand)

Estrogen feedback to the GnRH neurons

19.00 Welcome cocktail

FEBRUARY 12

Symposium 1 - MOOD DISORDERS AND STRESS

Chairs: Brunton P.J. (UK), Riva M.A. (Italy)

9.00 Shannon Weickert C., Owens S.J., Purves-Tyson T.D., Webster M.J., Weickert T.W. (Australia) Increased adolescent testosterone sets the stage for schizophrenia

9.30 Wiechmann T., Roeh S., Czamara D., Sauer S., Koedel M., Provençal N., Binder E.B. (Germany) Cross-tissue relevant epigenetic changes in the FKBP5 locus: relevance for stress-related psychiatric disorders

10.00 Meijer O.C. (The Netherlands) Glucocorticoid receptors in brain stress circuits: downstream signalling and cell specific effects

11.00 Lai Y., Brunton P.J. (UK) A role for hippocampal mineralocorticoid receptors in differentially modulating spatial learning under stressful conditions in prenatally stressed rats

11.15 Cattaneo A., Luoni A., Cattane N., Pape J., Mariani N., Binder E.B., Riva M.A., Pariante C.M. (Italy) Long lasting SGK1 modulation in response to early life stress: focus on epigenetic mechanisms

11.30 Amianto F., Abbate Daga G., Fassino S. (Italy) Gender differences in the personality traits: hormones or attachment?

11.45 Giatti S., Santi D., Spezzano R., Grimoldi M., Tabacchi T., Fusco M.L., Diviccaro S., Carra G., Caruso D., Simoni M., Cavaletti G., Melcangi R.C. (Italy) Post-finasteride syndrome: neuroactive steroid levels, psychiatric and andrological features

12.00 Weickert T.W., Ji E., Kyaw M., Moore L.T., Morris R., Vercammen A., Shannon Weickert C. (Australia) Testosterone influences cognition and brain activity in men with schizophrenia

12.15-13.00 PLENARY LECTURE

Chair: Mensah-Nyagan A.G. (France)

Papadopoulos V. (USA)

Translocator protein (18 kDa): an update on its structure and function

Symposium 2 - SIGNALING PATHWAYS

Chairs: Arévalo A. (Spain), Vallée M. (France)

15.00 Kelly M.J., Qiu J., Wagner E.J., Rønnekleiv O.K. (USA) Integration of the anorexigenic effects of estradiol and metabolic hormones by hypothalamic arcuate neurons

15.30 Brown A.R., Mitchell S.J., Herd M.B., Belelli D., Lambert J.J. (UK) Developmentally regulated pregnane steroid synthesis enhances GABA-ergic neurotransmission in mouse thalamocortical neurons and cortical pyramidal neurons

16.00 Tasker J.G., Chen C., Jiang Z., Weiss G. (USA) Stress desensitization of hypothalamic adrenoreceptors via a rapid, glucocorticoid receptor-dependent mechanism

17.00. Frye C.A., Walf A.A. (USA) Pregnane xenobiotic receptor (PXR) knockout rats respond to allopregnanolone but neither ligands for progestin receptors nor PXR for neurosteroid-mediated motivated behaviors

17.15 Hsu C-Y, Wu T-H, Wu R-Y, Lu K-T, Chung B-c (Taiwan) Neurosteroid pregnenolone stabilizes cytoskeletons to promote brain functions

17.30 de Bournonville C., de Bournonville M.P., van Eeckhaut A., Smolders I., Ball G.F., Balthazart J., Cornil C.A. (Belgium) Changes in preoptic estradiol and glutamate concentration in the preoptic area during male sexual behavior

17.45 Inoue M., Matsuoka H., Harada K. (Japan) Regulation of GABA signaling by adrenal cortical steroids in adrenal medullary cells

FEBRUARY 13

Symposium 3 - SEX DIFFERENCES

Chairs: Garcia-Segura L.M. (Spain), Melcangi R.C. (Italy)

9.00 Gaignard P., Fréchou M., Liere P., Thérond P., Schumacher M., Slama A., Guennoun R. (France) Sex differences in brain mitochondrial metabolism: influence of endogenous steroids and effect of stroke

9.30 Cambiasso M.J. Cisternas C.D. (Argentina) Sex chromosome effects on aromatase expression and regulation in mouse developing brain

10.00 Bonthuis P.J., Addison M.L., Quinnies K.M., Harris E.P., Rissman E.F. (USA) Sex differences in neural growth hormone and body weight: effects of X-chromosome gene dosage and estradiol

11.00 Monks D.A., Swift-Gallant A. (Canada) Non-neural androgen receptors affect sexual differentiation of brain and behavior

11.30 Van Hemmen J., Bakker J. (Belgium) The sexual differentiation of the human brain is affected by multifactorial mechanisms: evidence from the complete androgen insensitivity syndrome

11.45 Bender R.A., Zhou L., Vierk R., Brandt N., Keller A., Gee C.E., Schäfer M.K.E., Rune G.M. (Germany) Sex-dependent regulation of aromatase-mediated synaptic plasticity in basolateral amygdala

12.00 Farinetti A., Marraudino M., Ponti G., Gotti S., Panzica G.C. (Italy) Sexually dimorphic effect of chronic treatment with tributyltin on brain circuits involved in the food intake behavior in adult mice

12.15-13.00 PLENARY LECTURE

Chair: Panzica G.C. (Italy)

Forger N. (USA)

Epigenetic mechanisms in sexual differentiation of the brain and behavior

Symposium 4 - FOCUS ON HUMAN BRAIN

Chairs: Balthazart J. (Belgium), Frye C.E. (USA)

15.00 Nguyen T.-V. (Canada) Developmental effects of androgens in the human brain

15.30 Brinton R.D. (USA) Metabolic aging of the female brain: risks and consequences

16.00 Bixo M., Johansson M., Bäckström T. (Sweden) Effects of GABA active steroids in the female brain with focus on the premenstrual dysphoric disorder

17.00-18.30

Round Table - STEROIDS AND GUT MICROBIOME/BRAIN AXIS

Chairs: Melcangi R.C. (Italy), Panzica G.C. (Italy), Tetel M. (USA)

Tetel M.J. (USA) Estradiol and diet alter the gut microbiome in female mice

O’ Mahony S.M. (Ireland) The role of the microbiota in disorders of the gut-brain axis

de Vries G.J., Holder M.K., Peters N.V., Whylings J., Fields C.T., Chassaing B., Gewirtz A.T. (USA) Food, microbiota, and behavior

FEBRUARY 14

Symposium 5 - NEW TECHNOLOGIES TO UNDERSTAND THE FUNCTIONS OF STEROID RECEPTOR EXPRESSING NEURONS IN VIVO

Chairs: Herbison A.E. (New Zealand), Panzica G.C. (Italy)

9.00 Kawata M. (Japan) Behavior is regulated by steroid hormone receptor-associated mechanism: lesson from new animal model

9.30 Khayum M.A., Doorduin J., Dierckx R.A.J.O., de Vries E.F.J. (Netherlands) PET imaging of steroid hormone receptors

10.00 Maggi A., Rizzi N. and Ciana P., Vegeto E., Villa A. (Italy) Endocrine influence on neuroinflammation: the use of reporter systems

11.15-12.00 SPECIAL LECTURE

Chair: Mitro N. (Italy)

Cartier N (France)

CYP46A1 and Modulation of brain cholesterol metabolism as a therapeutic approach for Alzheimer disease.

Symposium 6 - NEUROPROTECTION AND NEUROINFLAMMATION

Chairs: Garcia-Segura L.M. (Spain), Viviani B. (Italy)

15.00 Brann D., Sareddy G., Zhang Q., Wang R., Vadlamudi R. (USA) Role of the ER coregulator, PELP1 in mediating the neuroprotective, anti-inflammatory and cognitive-enhancing effects of estrogen in the brain

15.30 Beyer C., Hoffmann S. (Germany) Sex steroids and inflammasomes: a neuroprotective alliance in the brain

16.00 Pak T.R. Shults C.L., Dingwall, C.B., Kim C.K. (USA) Functional dynamics of estrogen receptor-beta in the aging female brain

17.00 De Nicola A.F., Garay L., Meyer M., Sitruk-Ware R., Guennoun R., Schumacher M., Gonzalez Deniselle M.C. (Argentina) Neurosteroidogenesis and progesterone anti-inflammatory/neuroprotective effects

17.30 Schumacher M., Bielecki B., Ghoumari A., Franklin R.J.M., Ghandour M.S., Traiffort E. (France) The unexpected role of testes, testosterone and the androgen receptor in spontaneous myelin regeneration

17.45 Morello M., Millet P., Landel V., Feron F. (Italy) Vitamin D and Alzheimer’s disease: a new perspective

FEBRUARY 15

Symposium 7 - ESTROGENS ACROSS THE LIFESPAN: RAPID AND CHRONIC INFLUENCES OF ESTROGENS ON STRUCTURAL PLASTICITY, MEMORY AND DISEASE

Chairs: Choleris E. (Canada), Galea L.A.M. (Canada)

9.00 Galea L.A.M. (Canada) Good news and bad news: the effects of estrogens on cognition and neuroplasticity during aging

9.30 Srivastava D.P. (UK) Rapid regulation of dendritic spine plasticity in health and disease

10.00 Choleris E., Phan A., Lymer J.M., Sheppard P.A.S., Ervin S.J.K. (Canada) Brain regions involved in the rapid action of estrogens and their receptors on learning

11.00 Sohrabji F. (USA) Estrogens and neuroprotection after stroke: effects of age

11.30 Mehta D., Rex-Haffner M., Pinborg A., Binder E.B., Frokjaer V.G. (Denmark) Gene expression profiles within a pharmacologically induced depression model – the role of estrogen in perinatal depression

11.45 Marraudino M., Ponti G., Farinetti A., Macchi E., Gotti S., Keller M., Collado P., Panzica G.C. (Italy) The sexually dimorphic obesogenic effect of early postnatal genistein administration on CD1 mice

12.00 Clark S., Rainville J., Vasudevan N. (United Kingdom) Can aggression in male mice be regulated in a non-genomic manner by steroids?

12.15-13.00 PLENARY LECTURE

Chair: Balthazart J. (Belgium)

Micevych P. (USA)

Estradiol membrane-initiated signaling and female reproduction

14.15-15.30 YOUNG INVESTIGATORS Symposium

Chairs: Frye C.A. (USA), Giatti S. (Italy), Mensah-Nyagan A.G. (France)

Du X., McCarthny C.R., Schroeder A., Notaras M.J., Grech A., Hill R.A. (Australia) BDNF maintains normal estrous cycling – relevance to schizophrenia

Overgaard A., Lieblich S.E., Wong S., Galea L.A.M., Frokjaer V.G. (Denmark) Behavioural and hippocampal changes across the pre- to postpartum transition in rats

Mitchell S.J., Maguire E.P., Swinny J.D., Seifi M., Belelli D., Lambert J.J. (Scotland) Neurosteroids: endogenous modulators of the GABA_A receptors of the nucleus accumbens

Nuzzo M.T., Marino M. (Italy) Novel application for estrogen receptor β ligands

Yanguas-Casás N., Crespo-Castrillo A., Arevalo M.A., Garcia-Segura L.M. (Spain) Sex differences in the phagocytic and migratory capacity of rat microglia

Silva M.S.B., Prescott M., Campbell R.E. (New Zealand) Dissecting the GABA-to-GnRH neuron network in the pathophysiology of polycystic ovary syndrome (PCOS)

CLOSURE OF THE MEETING