VIRTUAL STEROIDS AND NERVOUS SYSTEM MEETING

Virtual Satellite

ALLOPREGNANOLONE AND ITS SYNTHETIC ANALOGUES: FROM BENCH TO CLINICAL STRATEGIES FOR NEUROPATHOLOGY

Torino (Italy) 11-12 February 2021

FEBRUARY 11 (hours are in Italy Local Time)

3.45 p.m. Opening remarks

4.00 p.m. Melcangi R.C. (Italy): Allopregnanolone: an overview on its synthesis and effects

4.30 p.m. Lambert J.J. (UK): Realising the therapeutic potential of neuroactive steroid modulators of the GABAa receptor

5.00 p.m. Gunduz-Bruce H. (USA): Clinical trials in postpartum depression with brexanolone and zuranolone

5.30 p.m. Bortolato M. (USA): The other side of the coin: neuropsychiatric side effects of allopregnanolone

FEBRUARY 12

4.00 p.m. Backstrom T. (Sweden): Allopregnanolone and Isoallopregnanolone, GABA-A receptor modulators with different effects useful in clinical conditions

4.30 p.m. Rasmusson A.M. (USA): A Role for Deficits in GABAergic Neurosteroids and Their Metabolites with NMDA-Receptor Antagonist Activity in the Pathophysiology of PTSD

5.00 p.m. Mennerick S (USA): Allopregnanolone: GABA-A receptors and beyond.

5.30 p.m. Reddy D.S. (USA): Cell-Specific and Phosphorylation-Dependent Actions of Brexanolone (Allopregnanolone) Analogs in Epilepsy and Brain Disorders

VIRTUAL MEETING

SCIENTIFIC PROGRAM

FEBRUARY 25 (hours are in Italy Local Time)

3.45-4.00 p.m. Opening remarks

4.00 p.m. J. Bakker (Belgium): Sexual differentiation of the human brain: role for sex hormones?

4.45 p.m. G. Rune (Germany): Sex dependent homeostasis of hippocampus synaptic stability and plasticity

5.30 - 6.30 p.m. Free communications from Young Researchers (I)

Rocks D., Jaric I., Gallo E., Greally J.M., Suzuki M., Kundakovic M. (USA) The role of EGR1 in a cyclic transcriptional program and behavioral plasticity across the estrous cycle

Rehbein E., Kogler L., Kotikalapudi R., Krylova M., Sundström Poromaa I., Derntl B. (Germany) Estradiol administration vs. pregnany - what impact does estradiol have on gray matter volume in women?

Aspesi D., Brill Z.R., Guillaume G., Choleris E. (Canada) Testosterone in the bed nucleus of the stria terminalis rapidly modulates social recognition and aggression in male mice

Isenbrandt A., Morissette M., Coulombe K., Bourque M., Lamontagne-Proulx J., Pradeloux S., Soulet D., Di Paolo T. (Canada) Role of gonads in the brain response of male and female mice to a MPTP lesion and Dutasteride treatment

Gross. K.S., Lincoln C.M., Anderson M.M., Geiger G.E., Frick K.M. (USA) Extracellular matrix metalloproteinase-9 (MMP-9) is required for estradiol enhancement of hippocampal memory consolidation

6.30 p.m. H. Ingraham (USA): Insights into how central estrogen modules control female physiology

7.15 - 8.30 p.m. Poster Session (I): Topics 1-3-5

7.15-7.50 P.M. discussion of odd posters (1, 3, 5 ...)

7.50-8.30 P.M. discussion of even posters (2, 4, 6 ...)

FEBRUARY 26

4.00 - 5.30 p.m. Poster Session (II): Topics 2-4-6-7-8

4.00-4.45 P.M. discussion of odd posters (33, 35, 37 ...)

4.45-5.30 P:M: discussion of even posters (32, 34, 36 ...)

5.30 p.m. J. Argente (Spain): Sexual precocity: unraveling the mechanisms of pubertal onset through clinical observations

6.15 p.m. S. Lightman (UK): The origin and importance of ultradian rhythms of the HPA axis in health and disease

7.00 - 8.00 p.m. Free communications from Young Researchers (II)

Barbiero I., De Rosa R., Zamberletti E., Gabaglio M., Tramarin M., Peroni D., Bianchi M., Rubino T., Kilstrup-Nielsen C. (Italy) Mechanism of action and therapeutic potential of pregnenolone-methyl ether (PME) on synaptic and cognitive defects associated with CDKL5 deficiency disorder

Viho E.M.G., Mahfouz A., Meijer O.C. (The Netherlands) Cell specificity of corticosteroid receptors’ signalling and interactions in the adult mouse hippocampus

Cáceres A.R.R., Vega-Orozco A.S., Laconi M.R. (Argentina) Effect of allopregnanolone over the female rat reproductive physiology

Court L., Balthazart J., Ball G.F., Cornil C.A. (Belgium) Long term effects of the inhibition of brain aromatase on the expression of socio-sexual behaviors in male japanese quail

Raux P.L., Lalanne V., Drutel G., Grel A., Marsicano G., Revest J.M., Vallée M. (France) Pregnenolone endogenous regulation of the cannabinoid type-1 receptor: characterization of the novel mutant mouse line CB1-E134G

8.00 - 8.15 p.m. Closure of the meeting