8th International Meeting

STEROIDS and NERVOUS SYSTEM

TORINO - February 14-18, 2015

SATURDAY 14

Satellite Symposium: GENDER INFLUENCE ON NEURODEGENERATIVE AND PSYCHIATRIC DISORDERS

Melcangi R.C. (Italy) Sex dimorphic levels of neuroactive steroids in physiological and pathological nervous system

Litim N., Bourque M., Morissette M., Di Paolo T. (Canada) Sex differences in Parkinson: different neuroprotective effect of sex steroids

Pike C.J., Christensen A., Moser V.A. (USA) Obesity and Alzheimer's disease: gender differences and sex steroid hormones

Eckert A. (Switzerland) Alzheimer, mitochondria and gender

Gold S.M. (Germany) Sex effects on inflammatory and neurodegenerative processes in autoimmunity

Kipp M., Beyer C. (Germany) Placenta-derived factors as possible immunosuppressive agents in autoimmune inflammatory brain disorders

Gibson C.L. (UK) The impact of gender on cerebral stroke pathology and treatment

Mendrek A. (Canada) Sex/gender differences in the neurocognitive function in schizophrenia

1Du X., Wu Y.W.C., van den Buuse M., Hill R.A. (Australia) A role for sex steroid hormones in the regulation of behaviours with relevance to schizophrenia

General discussion and Closure of the Satellite Symposium

REGULAR MEETING

SATURDAY 14

OPENING LECTURE

Balthazart J. (Belgium)

Is research on organizational effects of steroids translational? The case of human sexual orientation

Chair: García-Segura L.M.

SUNDAY 15 - San Luigi Hospital - Orbassano

CURRENT PERSPECTIVES ON NEUROBEHAVIORAL SEXUAL DIMORPHISMS

Chair: Wagner E. and Panzica G.C.

De Vries G.J. (USA) Sexual differentiation of the brain seen from a whole-body perspective

Panzica G.C., Bo E., Martini, M., Miceli D., Mura E., Rodriguez-Gomez A., Gotti S. (Italy) Sexually dimorphic effects of endocrine disruptors on brain and behavior

Shah N (USA) Modular genetic and neural control of social behaviors

Rivas V.M., Vargas A., Meza C., Kachani M., Wagner E.J. (USA) Modulatory influences of estradiol and other anorexigenic hormones on metabotropic, G_i/o-coupled receptor function in the hypothalamic control of energy homeostasis

PLENARY LECTURE

Rae Silver (USA)

Sex differences in circadian timing system: why we care

Chair: J. Balthazart

STRESS IN PREGNANCY: LONG-TERM EFFECTS ON STEROID PATHWAYS.

Chair: Hirst J., Walker D.

Reynolds R.M. (UK) Stress in pregnancy: long-term effects on steroid pathways

Donadio M.V., Lai Y., Yao S.T., Greenwood M., Murphy D., Russell J.A., Brunton P.J. (UK) Stress during pregnancy: sex-dependent effects on steroid pathways in the offspring brain

Hirst J.J., Walker D.W., Bennett G.A., Cumberland A.L., Shaw J.C., Palliser H.K. (Australia) Loss of steroid-mediated neuroprotection following stress in fetal life

Walker D.W., Quinn T.A., Ratnayake U., Dickinson H., Castillo-Melendez M. (Australia) The feto-placental unit revisited – the role of the fetal adrenal gland, brain, and placenta in provision of the androgen DHEA to protect the developing brain

Matthews S.G. (Canada) Glucocorticoid programming of stress pathways: a transgenerational perspective

MONDAY 16

NEUROLOGICAL CONSEQUENCES OF DISORDERED STEROID SIGNALING

Chair: Balthazart J., Melcangi R.C.

Patisaul H.B. (USA) Rewired: endocrine disruption of sexually dimorphic neuroendocrine signaling pathways

Campbell R.E., Prescott M., Marshall C., Yip S.-H., Moore A.M. (New Zealand) Disrupted progesterone signaling in the neuroendocrine genesis of polycystic ovarian syndrome

Maguire J. (USA) Peripartum changes in gabaergic control of the hippocampus and HPA axis: implications for maternal mood

Giatti S., Foglio B., Romano S., Garcia-Segura L.M., Panzica G.C., Caruso D., Melcangi R.C. (Italy) Effect of finasteride treatment in male rat nervous system

Bortolato M., Godar S.C., Mosher L., Pes R., Frau R., Devoto P. (USA) Role of neurosteroids in the pathophysiology of Tourette syndrome and pathological gambling

PLENARY LECTURE

Schumacher M. (France)

Neuroprotective effects of steroids

Chair: Melcangi R.C.

NEUROACTIVE STEROIDS AND GLIAL CELLS

Chair: Garcia-Segura L.M., Mensah-Nyagan A.G.

Garcia-Segura L.M., Arevalo M.A., Azcoitia I., Ruiz-Palmero I., Lopez-Rodriguez A.B., Acaz-Fonseca E. (Spain) Estrogenic regulation of reactive gliosis

Pellegrini E., Diotel N., Vaillant-Capitaine C., Pérez R., Gueguen M., Cano Nicolau J., Cruciani C., Nasri A., Kah O. (France) Steroid modulation of neurogenesis: focus on radial glial cells in zebrafish

Khalaj A.J., Moore S., Hasselmann J., Katzenellenbogenand J.A., Tiwari-Woodruff S.K. (USA) Nudging oligodendrocyte intrinsic signaling to remyelinate and repair: estrogen receptor ligand effects

Bilbo S.D. (USA) Sex differences in developing hippocampal microglia of mice: relevance for neurodevelopmental disorders

Nicot A.B., Guillot F., Garcia A., Salou M., Brouard S., Laplaud D.A. (France) Expression of gene transcripts involved in steroid metabolism from laser-captured mouse white matter astrocytes

Mitro N., Cermenati G., Audano M., Giatti S., Azcoitia I., Garcia-Segura L.M., Melcangi R.C., Caruso D. (Italy) A new pathway to exert protective effects on diabetes peripheral neuropathy: role of neuroactive steroids on myelin lipid profile

TUESDAY 17

GABA-A RECEPTOR MODULATING STEROID ANTAGONISTS (GAMSA). A NEW TREATMENT CONCEPT FOR CNS DISORDERS.

Chair: Backstrom T. (Sweden), Brunton P. (UK)

Strömberg J., Malinina E., Johansson M., Ragagnin G., Haage D., Lundgren P., Wang M., Taube M., Bäckström T. (Sweden) GABA_A receptor modulating steroid antagonist (GAMSA)

Johansson M., Turkmen S., Strömberg J., Ragagnin G., Malinina E., Haage D., Öfverman C., Lundgren P., Birzniece V., Zingmark E., Bäckström T. (Sweden) Antagonism of allopregnanolone-induced learning and memory disturbance by GAMSA

Butterworth R.F. (Canada) Neurosteroids in hepatic encephalopathy

Agusti A., Llansola M., Hernández-Rabaza V., Montoliu. C, Felipo V. (Spain) Modulation of GABA_A receptors by steroids. A new concept to improve cognitive and motor alterations in hepatic encephalopathy

ROUND TABLE - NEUROSTEROIDOGENESIS TODAY

(sponsorised by Journal of Neuroendocrinology)

Chair: Melcangi R.C., Panzica G.C.

Porcu P., Cook J.B., Werner D.F., Maldonado-Devincci A.M., Leonard M.N., Fisher K.R., O’Buckley T.K., McCown T.J., Besheer J., Hodge C.W., Morrow A.L. (USA) Overexpression of the steroidogenic enzyme cytochrome P450 side chain cleavage in the ventral tegmental area increases 3A,5A-THP and reduces long-term operant ethanol self-administration

Yang S.-Y., He X.-Y., Isaacs C., Dobkin C., Miller D., Philipp M. (USA) Roles of 17b-hydroxysteroid dehydrogenase type 10 in neurodegenerative disorder

Barron A.M., Asih P. , Ji B. , Suhara T. , Pike, C.J., Katsifis A., Martins R.N., Higuchi M. (Japan) Translocator protein as a therapeutic target for Alzheimer`s disease

Koonce C.J., Rusconi J.C., Walf A.A., Drew K., Frye C.A. (USA) Progesterone enhances and pregnane xenobiotic receptor deletion attenuates exploratory, anxiety and social behaviors in female rats

YOUNG INVESTIGATOR Symposium

Chair: Frye C.A., Mensah-Nyagan A.G.

Lopez-Rodriguez A.B., Acaz-Fonseca E., Viveros M.P., Garcia-Segura L.M. (Spain) Molecular changes in the brain of male and female mice after traumatic injury: association with brain edema and neurological deficit

Acaz-Fonseca E., Duran J., Carrero P., Arevalo M.A. Garcia-Segura L.M. (Spain) Sex differences in glia reactivity after cortical brain injury

Yawno T., Fahey M.C., Aridas J., Miller S.L., Walker D.W. (Australia) New approaches to treatment of neonatal seizures

Cumberland A.L., Palliser H.K., Hirst J.J. (Australia) Female juvenile guinea pigs display increased anxiety-like phenotype following reduced allopregnanolone exposure in utero

Grimm A., Mensah-Nyagan A.G., Eckert A. (France) Mitochondrial dysfunction in Alzheimer's disease: insights into neuroprotective effects of neurosteroids

Nuzzo M.T., Fiocchetti M., Ascenzi P., Marino M. (Italy) Estrogen effect in neuroprotection and neurodegeneration relies on HTT-NGB association

WEDNESDAY 18

LOCALLY DERIVED ESTRADIOL IN THE PREFRONTAL CORTEX AND HIPPOCAMPUS ENHANCES MEMORY AND BLOCKS DELETERIOUS EFFECTS OF STRESS

Chair: Balthazart J., Luine V.

Rune G.M. (Germany) Aromatase inhibition abolishes LTP generation in female but not in male mice

Luine V. (USA) Estradiol rapidly enhances memory, increases dendritic spines and protects against stress-induced memory impairments

Gall C.M., Kramár E.A., Lynch G. (USA) Estradiol collaborates with other synaptic modulatory receptors in the regulation of glutamatergic transmission

Zhen Y. (USA) (presented by Popoli M.) Local estradiol synthesis and action in the prefrontal cortex blocks stress-induced impairments in recognition memory in female rats

Ruiz-Palmero I., Garcia-Segura L.M., Arevalo M.-A. (Spain) Neuritogenesis and its regulation by estradiol are sexually dimorphic in primary mouse hippocampal neurons

Yamazaki T., Ishihara Y., Yamamoto M. (Japan) Neuroprotection by de novo synthesized estradiol and brain-converted allopregnanolone in cultured rat hippocampus

Special Lecture:

Monique Vallee (France)

A novel therapeutic potential for neurosteroids: focus on pregnenolone and CB1-mediated cannabinoid functions

Chair: Melcangi R.C.

COULD MEN AND WOMEN UNDERGOING (EARLY) MENOPAUSE BENEFIT FROM SPECIFIC PHYTOESTROGENIC PRODUCTS TO REDUCE LATER LIFE DEMENTIA RISK?

Chair: Hogervorst E. and Rahardjo, T.

Rocca W.A. (USA) Oophorectomy, early menopause, estrogen, and dementia: a 2015 update

Irsan A.K., Hardinsyah, Winarno A., Rahardjo T.B., Hogervorst E. (Indonesia) Tempe reversed the effects of ovariectomy on brain function in ovx rats: effects of age and type of soy product

Soni M., White L. R., Bandelow S., Launer L., and Hogervorst E (UK) Food for thought: does tofu interact with thyroid function to effect cognition in elderly populations?

Hogervorst E Xu Xin, Mira Soni, Atik Kridawati, Xiao Shifu, Tri Budi Rahardjo (UK, China, Indonesia) Phyoestrogens, menopause and dementia risk: present and future