SNS2019
SATELLITE SYMPOSIUM
STEROIDS AND THE NERVOUS SYSTEM: PAST AND FUTURE
February 16 - Torino
Organizers: Melcangi R.C. (Italy), Panzica G.C. (Italy)
9.00 Melcangi R.C. and Panzica G.C. (Italy) Introduction to the Symposium
9.30 Herbison A.E. (New Zealand) Unravelling the estrogen regulation of the GnRH neuronal network through technical innovation
10.10 Balthazart J. (Belgium) New concepts in the study of the sexual differentiation and activation of reproductive behaviors, a personal view
10.50 McCarthy M. (USA) Replacing Neurosteroids with Neuroimmunity during the quest to uncover origins of sex differences in the brain
11.30 Melcangi R.C. (Italy) Sex dimorphism of neurosteroidogenesis: physiopathological role
13.30 Panzica G.C., Bonaldo B., Farinetti A., Marraudino M., Ponti G., Gotti S. (Italy) Steroid sensitive circuits and behavior: critical endpoints for endocrine disruption
14.10 Garcia-Segura L.M. (Spain) Neuroprotective mechanism of estradiol: an overview of twenty years of research
14.50 Vallée M. (France) Stress and drug abuse disorders: the promising therapeutic value of neurosteroids
15.30 Mensah-Nyagan G. Meyer L., Taleb O., Patte-Mensah C. (France) Neurosteroid-based therapeutic strategy and neuropathic pain management
16.10 Frye C.M. Torgersen J.K. (USA) The role of androgenic neurosteroids in the etiopathophysiology and treatment of social, cognitive, affective and neurodegenerative disorders
16.50 Closure of the Satellite Symposium
10th International Meeting
STEROIDS and NERVOUS SYSTEM
FEBRUARY 16 - Meeting
18.00 OPENING LECTURE
Ball G.F. (USA)
Pleiotropic effects of testosterone: lessons from studies of the avian song system
FEBRUARY 17
SYMPOSIUM - Aromatase in the female brain - Why produce locally when available globally?
9.00 Cornil C.A. (Belgium): Neuroestrogens and female sexual behavior
9.30 de Bournonville C., McGrath A., Mendoza K.R., Remage-Healey L. (USA) Steroid synthesis in the auditory forebrain of female zebra finches in response to song
10.00 Frick K.M. (USA): The role of hippocampal estradiol synthesis in regulating memory formation
10.30 Blaustein J.D. (USA): Aromatase inhibitors in postmenopausal women with breast cancer: what about the brain?
11.30 Gintzler A.R., Storman E.M., Liu N.-J., Wessendorf M.W. (USA) Membrane estrogen receptor alpha and aromatase form signaling complexes in the CNS: implications for region-specific estrogenic signaling
11.45 Rehbein E., Hornung J., Morawetz C., Bayer J., Krylova M., Sundström Poromaa I., Derntl B. (Germany) Does estradiol influence behavioral and neural emotion regulation performance?
12.15-13.00 PLENARY LECTURE
Torres Aleman I. (Spain)
The blood-brain-barrier and the cross-talk of estradiol and IGF-1 in mood regulation
SYMPOSIUM - Sex differences in fear and stress responses: relevance to disease vulnerability and treatment for psychopathology
14.00 Bangasser D. (USA): Sex differences in stress regulation and cognition
14.30 Dalla C., Kokras N. (Greece): Sex differences in psychopharmacology: from estrogens to neuroestrogens in models of depression
15.00 Milad M. (USA): Fear extinction: her and his brains
SYMPOSIUM - Prevention of behavioral disorders caused by stress-induced disruption of steroid pathways in pregnancy and in the early postnatal period.
16.00 Sze Y., Fernandes J., Gill A.C., Brunton P.(UK): Effects of prenatal stress on neurosteroid pathways in the offsprings
16.30 Matthews S. (Canada): Glucocorticoid Programming of the Fetal Brain: Intergenerational Consequences
17.00 Hirst J. (Australia): Loss of neurosteroid support contributes to adverse long term behavioural outcomes following preterm birth
17.30-18.30 Round table - The problem with sex differences
Galea L. (Canada): Mandating the study of sex differences will NOT improve women’s health
Sohrabji F. (USA): Sex differences in therapeutics: is it time to consider a blue pill/pink pill?
Choleris E. (Canada): Underpowered research on sex differences and sex-specific analyses
McCarthy M.M. (USA) How the complexity of sex differences leads to misinterpretation and misunderstanding by researches and reviewers alike
FEBRUARY 18
SYMPOSIUM - Molecular mechanisms of glucocorticoid effects
9.00 De Franco D.B., Franks A.L., Berry K.J., Jaumotte J.D., Bargerstock Murillo E., Rudine A.R., Monaghan-Nichols A.P. (USA) Regulation of glucocorticoid responses in the developing rodent brain
9.30 Garabedian M.J., Chao M.V., Jeanneteau F. (USA): Regulation of glucocorticoid receptor phosphorylation and genomic action by brain-derived neurotrophic factor in cortical neurons
10.00 Krugers H. (The Netherlands): Glucocorticoid effects on memory formation: role of synapses and early life experiences
10.30 Hunter R. (USA): Glucocorticoid receptor interactions with the deep genome
11.30 Crombie G.K., Palliser H.K., Shaw J.C., Hodgson D.M., Walker D.W., Hirst J.J. (Australia) Placental role in neuroprotective responses to prenatal stress in the guinea pig
11.45 Sivukhina E.V., Jirikowski G.F. (Germany) Corticosteroid-binding globulin expression is upregulated upon increased magnocellular neuronal activity in rats
12.15-13.00 PLENARY LECTURE
Pariante C. (UK)
Glucocorticoids, inflammation and psychiatric illness
13.00-14.00 Poster exhibition
SYMPOSIUM - Countering neuroactive steroids: a novel therapeutic avenue in neuropsychiatry?
14.00 Di Paolo T., Litim N., Poirier A-A., Jarras H., Côté M., Al Sweidi S., Morissette M., Caruso D., Melcangi R., Soulet D. (Canada) Effects of 5alpha-reductase inhibitors in the brain and gut of MPTP mouse model of Parkinson’s disease
14.30 Frau R., Traccis F., Fanni S., Giua G., Saba P., Caruso D., Scheggi S., Soggiu A., Roncada P., Devoto P., Bortolato M. (Italy) Blocking neurosteroidogenesis as a novel tool for the cognitive complications of sleep disorders
15.00 Bortolato M. (USA) Inhibition of neurosteroidogenesis as a therapy for impulse-control problems and substance use disorders
SYMPOSIUM - Toward a sex dimorphic neurology
16.00 Rocca W.A. (USA): Sex, gender and Parkinson’s disease
16.20 Mielke M.M. (USA): Sex, gender and dementia
16.40 Vemuri P. (USA): Sex differences in imaging biomarkers in aging and cognitive resilience
17.00 Miller V.M., Jayachandran M., Barnes J.N., Mielke M.M., Kantarci K., Rocca W.A. (USA) Sex, hormones and neurovascular aging
FEBRUARY 19
SYMPOSIUM - Sex differences and effects of neuroactive steroids on brain mitochondrial function and metabolism
8.30 Acaz-Fonseca E., Ortiz-Rodriguez A., Lopez-Rodriguez A.B., Garcia-Segura L.M., Heyde I., Oster H., Astiz M. (Germany) Developmental effects of neuroactive steroids in mouse brain mitochondria
9.00 Frago L.M., Guerra-Cantera S., Freire-Regatillo A., Barrios V., Argente J., Chowen J.A. (Spain) Sex differences in the neuroendocrine control of metabolism and the implication of astrocytes
9.30 Barreto G.E. (Colombia) Tibolone reduces oxidative damage and inflammation in microglia stimulated with palmitic acid through mechanisms involving estrogen receptor beta
10.30 Eckert A. (Switzerland) Effects of sex hormones on mitochondrial activity and bioenergetics – implications for Alzheimer’s disease
11.00 Kammel L.G., Van Veen J.E., Bunda P.C., Shum M., Zhang Z., Massa M.G., Reid M.S., Hrncir H., Arnold A.P., Liesa M., Yang X., Correa S.M. (USA) Sex differences in the transcriptional architecture of the VMH reveal two estrogen-sensitive neuron clusters that coordinately regulate energy expenditure in females
11.15 Raval P., Mukherjee J., Sellers K.J., Creeney H., Durate R.R.R., Moss S.J., Brandon N.J., Srivastava D.P. (UK) Estradiol regulates the synaptic proteome through a local translation mechanism in a sexually dimorphic manner.
11.30-12.15 SPECIAL LECTURE
Shah N.M. (USA)
Molecular and neural control of sexually dimorphic social behaviors
12.15-14.00 POSTER DISCUSSION
SYMPOSIUM - Multi-faceted functions of estrogens in the ventromedial hypothalamic nucleus
14.00 Xu Y. (USA): An estrogen-responsive neural network: start from the ventromedial hypothalamic nucleus
14.30 López M. (Spain): Complex lipid metabolism within the VMH mediates the central actions of estradiol on energy balance
15.00 Routh V. (USA): Estrogen regulation of ventromedial hypothalamus glucose-inhibited neurons may play a role in glucose homeostasis
15.30 Lin D. (USA): The VMHvl and female aggression
FEBRUARY 20
SYMPOSIUM - Molecular tools unleashed for the study of neuroactive steroid synthesis and action
9.00 Remage-Healey L. (USA): Viral targeting of neuronal subtypes to dissect rapid neurosteroid regulation of sensory cortex
9.30 Moenter S. (USA): Estradiol feedback on the reproductive neuroendocrine system
10.00 Ábrahám I.M., Barabás K., Kovács T., Kovács G., Ernszt D., Jánosi T.Z., Godó S. (Hungary) Super-resolution imaging of rapid estradiol effects on surface movement of glutamate receptors in live neurons
10.30 Stincic T. (USA): Optogenetics and calcium imaging reveal novel actions of estrogenic signaling on hypothalamic circuits that regulate energy balance
11.00 Routh V. (USA): Estrogen regulation of ventromedial hypothalamus glucose-inhibited neurons may play a role in glucose homeostasis
11.30 Lin D. (USA): The VMHvl and female aggression
12.00-13.00 PLENARY LECTURE
Prevot V. (France)
Hypothalamic neuronal circuits controlling reproduction and steroid hormones: a role for nitric oxide?
14.00-15.00 YOUNG INVESTIGATORS Symposium
14.00 Marrocco J., Einhorn N.R., Li H., Schmidt P.J., Lee F.S., McEwen B.S. (USA) Cross-species epigenetic signature induced by ovarian hormones.
14.10 De Wit A.E., Booij S.H., Giltay E.J., Joffe H., Schoevers R.A., Oldehinkel A.J. (the Netherlands) Associations of oral contraceptive use and depressive symptoms in adolescents and young women
14.20 Duarte-Guterman P., Lieblich S.E., Mahmoud R., Ibrahim M., Skandalis D.A., Galea L.A.M. (Canada) The short and long term impact of motherhood on hippocampal neurogenesis, inflammation, and gene expression
14.30 Mariani N., Cattaneo A., Calpighi C., McLaughlin A.P., Nikkheslat N., Hastings C., Nettis M.A., Zajowska Z., Cowen P., Cavanagh J., Harrison N., Bullmore E., The Wellcome Trust NeuroImmunology of Mood disorders and Alzheimer’s disease (NIMA) consortium, Mondelli V., Pariante C.M. (UK) Modulation of glucocorticoid receptors in the blood mRNA of patients with depression: a study in treatment resistant, treatment responsive, or untreated patients
14.40 Turano, A., Haas, N.A. M.S., Schwarz, J.M. PhD (USA) Examining the impact of neuroimmune dysregulation on social behavior in male and female juvenile rats
14.50 Viho E.M.G., Buurstede J.C., Koorneef L.L., Mahfouz A., Houtman R., Hunt H., Kroon J., Meijer O.C. (the Netherlands) Putative coregulator interactions underlying differential glucocorticoid receptor modulation effects in memory consolidation
SYMPOSIUM - Vitamin D and brain
15.00 Norlin M. (Sweeden): Vitamin D and the brain - potential effects on steroidogenesis in the nervous system and possible role in the treatment of brain cancer
15.30 Jirikowski G.F. (Germany): Vitamin D binding proteins and their localization in the nervous system
16.00 Cui X. (Australia): Vitamin D modulates dopamine development via its genetic and epigenetic actions
SYMPOSIUM - The impact of endocrine disrupting chemicals (EDCs) interfering with steroid signaling on neurodevelopment
17.00 Patisaul H. (USA) The CLARITY-BPA Project: Reproductive evidence of low dose effects on the developing brain
17.30 Lichtensteiger W., Bassetti-Gaille C., Rehrauer H., Kühn Georgijevic J., Tresguerres J.A.F., Schlumpf M. (Switzerland) Sex-dependent effects of behaviorally active chemicals on genes regulating interneuron development in hippocampus: possible role of microRNA
18.00 Parent A.S., López-Rodríguez D., Franssen D., Lomniczi, A., Bourguignon J.P. (Belgium) Neuroendocrine disruption of puberty and reproduction