略歴

平成 3年（1991）  1月 千葉県生まれ

⚪学歴

平成21年（2009）4月 北里大学薬学部薬学科　入学

平成27年（2015）3月 北里大学薬学部薬学科　卒業

平成27年（2015）4月 筑波大学人間総合科学研究科生命システム医学専攻 入学

平成31年（2019）3月 筑波大学人間総合科学研究科生命システム医学専攻 修了 博士（医学）取得（長瀬 博 教授）

論文題目「モルヒナン骨格を有する新規オレキシン1受容体拮抗薬の結合必須構造の検討」

⚪職歴

平成31年（2019）4月 公益財団法人乙卯研究所　入所

令和2年（2020）4月 明治薬科大学薬品製造化学研究室　助教                                                                   

現在に至る

⚪所属学会

日本薬学会、有機合成化学協会

⚪受賞歴

平成29年（2017）9月　　薬学会関東支部大会　優秀口頭発表賞

研究業績

⚪原著論文

10. Kakeru Matsukuma, Masanori Tayu, Masahiro Noji, Satoshi Hayashi, Sayaka Ohrui, Nozomi Saito

"A General Catalytic Sulfide-based Electron Donor–Acceptor Complex Platform for Decarboxylative Transformations of N-Hydroxyphthalimide Esters"

Adv. Synth. Catal. 2025, 367, e202500196. [DOI]

9. Kakeru Matsukuma, Masanori Tayu, Takumi Ogino, Sayaka Ohrui, Masahiro Noji, Satoshi Hayashi, Nozomi Saito

"Photoredox/Sulfide Dual Catalysis for Modular Synthesis of Multi-Substituted Furan Rings via Catalytic Indirect Reductive Quenching"

Chem. Asian J. 2025, 20, e202401442. [DOI] (Selected as a cover picture)

8. Masanori Tayu, Kakeru Matsukuma, Tomohisa Yamaguchi, Masahiro Noji, Satoshi Hayashi, Sayaka Ohrui, Nozomi Saito

"Photoredox Catalysis Using Methoxyarenes: Mechanistic Studies and Synthetic Applications"

Bull. Chem. Soc. Jpn. 2024, 97, uoae138. [DOI]

7. Kakeru Matsukuma, Masanori Tayu, Yuriko Yashiro, Tomohisa Yamaguchi, Sayaka Ohrui, Nozomi Saito

"A Photoredox/Sulfide Dual Catalysis System That Uses Sulfide Radical Cations to Promote Alkene Chlorotrifluoromethylation"

Chem. Pharm. Bull. 2023, 71, 695-670. [DOI]

6. Kentaro Kagami, Xueying Liang, Nanako Ishibashi, Sayaka Ohrui, Masanori Tayu, Nozomi Saito

"Synthesis of N-(acyloxy)-N-alkynylamides via generation of “C2” from hypervalent alkynyliodane and a weak base"

Chem. Commun. 2023, 59, 8274-8277. [DOI]

5. Sayaka Ohrui, Yoko Irukayama-Tomobe, Yukiko Ishikawa, Masashi Yanagisawa, Hiroshi Nagase

"Design and Synthesis of Novel Orexin Antagonists via Structural Simplification of the Morphinan Skeleton"

Heterocycles 2021, 103, 929-951. [DOI]

4. Naoshi Yamamoto, Sayaka Ohrui, Takahiro Okada, Tsuyoshi Saitoh, Noriki Kutsumura, Yasuyuki Nagumo,

Yoko Irukayama-Tomobe, Yasuhiro Ogawa, Yukiko Ishikawa, Yurie Watanabe, Daichi Hayakawa, Hiroaki Gouda, 

Masashi Yanagisawa, Hiroshi Nagase

"Essential structure of orexin 1 receptor antagonist YNT-707, Part III: Role of the 14-hydroxy and 3-methoxy groups in the YNT-707 derivatives without 4,5-eopxy ring on orexin 1 receptor antagonistic activity"

Bioorg. Med. Chem. 2019, 27, 1747-1758. [DOI]

3. Sayaka Ohrui, Naoshi Yamamoto, Tsuyoshi Saitoh, Noriki Kutsumura, Yasuyuki Nagumo, YokoIrukayama-Tomobe, Yasuhiro Ogawa, Yukiko Ishikawa, Yurie Watanabe, Daichi Hayakawa, Hiroaki Gouda, Masashi Yanagisawa, Hiroshi Nagase

"Essential structure of orexin 1 receptor antagonist YNT-707, Part II: Drastic effect of the 14-hydroxy group on the orexin 1 receptor antagonistic activity"

Bioorg. Med. Chem. Lett. 2018, 28, 774-777.  [DOI]

2. Naoshi Yamamoto, Sayaka Ohrui, Takahiro Okada, Masahiro Yata, Tsuyoshi Saitoh, Noriki Kutsumura, Yasuyuki Nagumo, Yoko Irukayama-Tomobe, Yasuhiro Ogawa, Yukiko Ishikawa, Yurie Watanabe, Daichi Hayakawa, Hiroaki Gouda, Masashi Yanagisawa, Hiroshi Nagase

"Essential structure of orexin 1 receptor antagonist YNT-707: Part I Role of the 4,5-epoxy ring for binding with orexin 1 receptor"

Bioorg. Med. Chem. Lett. 2017, 27, 4176-4179. [DOI]

1. Hiroshi Nagase, Naoshi Yamamoto, Masahiro Yata, Sayaka Ohrui, Takahiro Okada, Tsuyoshi Saitoh, Noriki Kutsumura, Yasuyuki Nagumo, Yoko Irukayama-Tomobe, Yukiko Ishikawa, Yasuhiro Ogawa, Shigeto Hirayama, Daisuke Kuroda, Yurie Watanabe, Hiroaki Gouda, Masashi Yanagisawa

"Design and Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and their Pharmacologies"

J. Med. Chem. 2017, 60, 1018-1040. [DOI]